Medulloblastoma epidemiology and demographics: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
(Created page with "{{Medulloblastoma}} {{CMG}} ==Incidence== Brain tumors are the second most common malignancy among children less than 20 years of age. Medulloblastoma is the...")
 
No edit summary
 
(28 intermediate revisions by 5 users not shown)
Line 1: Line 1:
__NOTOC__
{{Medulloblastoma}}
{{Medulloblastoma}}
{{CMG}}
{{CMG}} {{AE}}{{HL}}{{sali}}
==Overview==
Medulloblastoma is the second most common brain tumor among the pediatric population.<ref name="wiki">Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015</ref> The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828  }} </ref> The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.<ref name="pmid23245832">{{cite journal| author=Bartlett F, Kortmann R, Saran F| title=Medulloblastoma. | journal=Clin Oncol (R Coll Radiol) | year= 2013 | volume= 25 | issue= 1 | pages= 36-45 | pmid=23245832 | doi=10.1016/j.clon.2012.09.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23245832  }} </ref> Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828  }} </ref>


==Incidence==
==Epidemiology and Demographics==
[[Brain tumor|Brain tumors]] are the second most common malignancy among children less than 20 years of age.  Medulloblastoma is the most common malignant brain tumor, comprising 14.5% of newly diagnosed cases.<ref name="seer">James G. Gurney, Malcolm A. Smith, Greta R. Bunin, [http://seer.cancer.gov/publications/childhood/cns.pdf CNS and Miscellaneous Intracranial and Intraspinal Neoplasms], SEER Pediatric Monograph, National Cancer Institute</ref>   In adults, medulloblastoma is rare, comprising less than 2% of CNS malignancies.<ref>[http://cbtrus.org/2005-2006/tables/2006.table12.pdf Selected Primary Brain and Central Nervous System Tumor Age-Specific Incidence Rates], Central Brain Tumor Registry of the United States, 1998-2002.</ref>
===Prevalence===
* Medulloblastoma is the second most common brain tumor among the [[pediatric]] population.<ref name="wiki">Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015</ref>
* Medulloblastoma is considered a rare [[tumor]] among adults, as it comprises fewer than 2% of all brain tumors among that age group.


The incidence of childhood medulloblastoma is higher in males (62%) than females (38%). <ref>[http://cbtrus.org/2005-2006/tables/2006.table13.pdf Selected Childhood Primary Brain and Central Nervous System Tumor Incidence Rates by Major Histology Groupings, Histology and Gender] Central Brain Tumor Registry of the United States, 1998-2002.</ref>  Medulloblastoma and other PNET tumors are more prevalent in younger children than older children.  40% of medulloblastoma patients are diagnosed before the age of 5, 31% are between the ages of 5 and 9, 18.3% are between the ages of 10 and 14, and 12.7% are between the ages of 15 and 19. <ref>[http://cbtrus.org/2005-2006/tables/2006.table15.pdf Selected Childhood Primary Brain and Central Nervous System Tumor Age-Specific Incidence Rates], Central Brain Tumor Registry of the United States, 1998-2002.</ref>
===Incidence===
* The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828  }} </ref>
 
===Age===
* The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.<ref name="pmid23245832">{{cite journal| author=Bartlett F, Kortmann R, Saran F| title=Medulloblastoma. | journal=Clin Oncol (R Coll Radiol) | year= 2013 | volume= 25 | issue= 1 | pages= 36-45 | pmid=23245832 | doi=10.1016/j.clon.2012.09.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23245832 }} </ref>
* The [[molecular]] subgroup of medulloblastoma has an influence on the age of presentation such as:<ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref>
:* WNT medulloblastoma subgroup presents among older children
:* SHH medulloblastoma subgroup presents among infants and adults
:* Group 3 medulloblastoma presents among younger children
:* Group 4 medulloblastoma presents among younger children
 
===Gender===
* The overall age adjusted incidence rate of medulloblastoma among males is approximately 0.84 per 100,000 individuals in the United States.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828  }} </ref>
* The overall age adjusted incidence rate of medulloblastoma among females is approximately 0.58 per 100,000 individuals in the United States.
* Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.
 
===Race===
* There is no racial predilection to medulloblastoma.<ref name="pmid2010773">{{cite journal| author=Roberts RO, Lynch CF, Jones MP, Hart MN| title=Medulloblastoma: a population-based study of 532 cases. | journal=J Neuropathol Exp Neurol | year= 1991 | volume= 50 | issue= 2 | pages= 134-44 | pmid=2010773 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2010773  }} </ref>


==References==
==References==
Line 12: Line 34:
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Disease]]
[[Category:Disease]]
[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Neurosurgery]]
[[Category:Neurosurgery]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Neurology]]
[[Category:Neurosurgery]]

Latest revision as of 14:38, 2 July 2019

Medulloblastoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Medulloblastoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case studies

Case #1

Medulloblastoma epidemiology and demographics On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Medulloblastoma epidemiology and demographics

All Images
X-rays
Echo and Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Medulloblastoma epidemiology and demographics

CDC on Medulloblastoma epidemiology and demographics

Medulloblastoma epidemiology and demographics in the news

Blogs on Medulloblastoma epidemiology and demographics

Directions to Hospitals Treating Medulloblastoma

Risk calculators and risk factors for Medulloblastoma epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Syed Musadiq Ali M.B.B.S.[3]

Overview

Medulloblastoma is the second most common brain tumor among the pediatric population.[1] The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.[2] The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.[3] Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.[2]

Epidemiology and Demographics

Prevalence

  • Medulloblastoma is the second most common brain tumor among the pediatric population.[1]
  • Medulloblastoma is considered a rare tumor among adults, as it comprises fewer than 2% of all brain tumors among that age group.

Incidence

  • The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.[2]

Age

  • The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.[3]
  • The molecular subgroup of medulloblastoma has an influence on the age of presentation such as:[4]
  • WNT medulloblastoma subgroup presents among older children
  • SHH medulloblastoma subgroup presents among infants and adults
  • Group 3 medulloblastoma presents among younger children
  • Group 4 medulloblastoma presents among younger children

Gender

  • The overall age adjusted incidence rate of medulloblastoma among males is approximately 0.84 per 100,000 individuals in the United States.[2]
  • The overall age adjusted incidence rate of medulloblastoma among females is approximately 0.58 per 100,000 individuals in the United States.
  • Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.

Race

  • There is no racial predilection to medulloblastoma.[5]

References

  1. ↑ 1.0 1.1 Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015
  2. ↑ 2.0 2.1 2.2 2.3 McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M; et al. (2013). "Trends in childhood brain tumor incidence, 1973-2009". J Neurooncol. 115 (2): 153–60. doi:10.1007/s11060-013-1212-5. PMC 4056769. PMID 23925828.
  3. ↑ 3.0 3.1 Bartlett F, Kortmann R, Saran F (2013). "Medulloblastoma". Clin Oncol (R Coll Radiol). 25 (1): 36–45. doi:10.1016/j.clon.2012.09.008. PMID 23245832.
  4. ↑ Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
  5. ↑ Roberts RO, Lynch CF, Jones MP, Hart MN (1991). "Medulloblastoma: a population-based study of 532 cases". J Neuropathol Exp Neurol. 50 (2): 134–44. PMID 2010773.


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Medulloblastoma_epidemiology_and_demographics&oldid=1574631"