Medulloblastoma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Syed Musadiq Ali M.B.B.S.[3]

Overview

Medulloblastoma is the second most common brain tumor among the pediatric population.[1] The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.[2] The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.[3] Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.[2]

Epidemiology and Demographics

Prevalence

  • Medulloblastoma is the second most common brain tumor among the pediatric population.[1]
  • Medulloblastoma is considered a rare tumor among adults, as it comprises fewer than 2% of all brain tumors among that age group.

Incidence

  • The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.[2]

Age

  • The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.[3]
  • The molecular subgroup of medulloblastoma has an influence on the age of presentation such as:[4]
  • WNT medulloblastoma subgroup presents among older children
  • SHH medulloblastoma subgroup presents among infants and adults
  • Group 3 medulloblastoma presents among younger children
  • Group 4 medulloblastoma presents among younger children

Gender

  • The overall age adjusted incidence rate of medulloblastoma among males is approximately 0.84 per 100,000 individuals in the United States.[2]
  • The overall age adjusted incidence rate of medulloblastoma among females is approximately 0.58 per 100,000 individuals in the United States.
  • Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.

Race

  • There is no racial predilection to medulloblastoma.[5]

References

  1. 1.0 1.1 Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015
  2. 2.0 2.1 2.2 2.3 McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M; et al. (2013). "Trends in childhood brain tumor incidence, 1973-2009". J Neurooncol. 115 (2): 153–60. doi:10.1007/s11060-013-1212-5. PMC 4056769. PMID 23925828.
  3. 3.0 3.1 Bartlett F, Kortmann R, Saran F (2013). "Medulloblastoma". Clin Oncol (R Coll Radiol). 25 (1): 36–45. doi:10.1016/j.clon.2012.09.008. PMID 23245832.
  4. Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
  5. Roberts RO, Lynch CF, Jones MP, Hart MN (1991). "Medulloblastoma: a population-based study of 532 cases". J Neuropathol Exp Neurol. 50 (2): 134–44. PMID 2010773.

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