Medulloblastoma classification

Jump to: navigation, search

Medulloblastoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Medulloblastoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case studies

Case #1

Medulloblastoma classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Medulloblastoma classification

All Images
X-rays
Echo and Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Medulloblastoma classification

CDC on Medulloblastoma classification

Medulloblastoma classification in the news

Blogs on Medulloblastoma classification

Directions to Hospitals Treating Medulloblastoma

Risk calculators and risk factors for Medulloblastoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Associate Editor(s)-in-Chief: Syed Musadiq Ali M.B.B.S.[3]

Overview

Medulloblastoma is classified into several subtypes based on the WHO histological classification system (classic vs. variant medulloblastoma) and the molecular subtypes classification system (WNT subgroup vs. SHH subgroup vs. Group 3 medulloblastoma vs. Group 4 medulloblastoma).[1][2][3][4][5]

Classification

WHO Histological Classification System

  • Medulloblastoma is classified into two main subtypes based on the WHO histological classification system which include classic medulloblastoma and variant medulloblastoma.[2][4][5]
  • Variant medulloblastoma may be further classified into desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic​ medulloblastoma, and medulloblastoma with extensive nodularity.


 
 
 
 
 
WHO histological classification system
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Classic medulloblastoma
 
 
 
 
 
Variant medulloblastoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Desmoplastic medulloblastoma
 
Large cell medulloblastoma
 
Anaplastic​ medulloblastoma
 
Medulloblastoma with extensive nodularity
 
 
 
 


Molecular Classification System

  • Medulloblastoma may be classified into at least four major subgroup based on the molecular classification system which include WNT subgroup, SHH subgroup, Group 3, and Group 4.[1][3]


 
 
 
 
 
 
 
Molecular classification system
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
WNT
 
SHH
 
Group 3
 
Group 4
 
 
 
 
 
WNT α
WNT β
 
SHH α
SHH β
SHH γ
 
Group 3 α
Group 3 β
 
Group 4 α
Group 4 β
 
 
 
 



References

  1. 1.0 1.1 Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T; et al. (2012). "Subgroup-specific structural variation across 1,000 medulloblastoma genomes". Nature. 488 (7409): 49–56. doi:10.1038/nature11327. PMC 3683624. PMID 22832581.
  2. 2.0 2.1 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A; et al. (2007). "The 2007 WHO classification of tumours of the central nervous system". Acta Neuropathol. 114 (2): 97–109. doi:10.1007/s00401-007-0243-4. PMC 1929165. PMID 17618441.
  3. 3.0 3.1 Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
  4. 4.0 4.1 Medulloblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28 2015
  5. 5.0 5.1 Medulloblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28 2015

Linked-in.jpg