Heart transplantation risk factors: Difference between revisions
Jump to navigation
Jump to search
Ifrah Fatima (talk | contribs) No edit summary |
Ifrah Fatima (talk | contribs) |
||
| Line 11: | Line 11: | ||
=== Donor factors=== | === Donor factors=== | ||
====Common risk factors==== | |||
Both the following factors are associated with an increased one-year mortality rate in the recipient. | Both the following factors are associated with an increased one-year mortality rate in the recipient. | ||
*Advanced donor age <ref name="PotapovLoebe1999">{{cite journal|last1=Potapov|first1=Evgenij V.|last2=Loebe|first2=Matthias|last3=H??bler|first3=Michael|last4=Musci|first4=Michele|last5=Hummel|first5=Manfred|last6=Weng|first6=Yu-guo|last7=Hetzer|first7=Roland|title=MEDIUM-TERM RESULTS OF HEART TRANSPLANTATION USING DONORS OVER 63 YEARS OF AGE1|journal=Transplantation|volume=68|issue=12|year=1999|pages=1834–1838|issn=0041-1337|doi=10.1097/00007890-199912270-00002}}</ref> | *Advanced donor age <ref name="PotapovLoebe1999">{{cite journal|last1=Potapov|first1=Evgenij V.|last2=Loebe|first2=Matthias|last3=H??bler|first3=Michael|last4=Musci|first4=Michele|last5=Hummel|first5=Manfred|last6=Weng|first6=Yu-guo|last7=Hetzer|first7=Roland|title=MEDIUM-TERM RESULTS OF HEART TRANSPLANTATION USING DONORS OVER 63 YEARS OF AGE1|journal=Transplantation|volume=68|issue=12|year=1999|pages=1834–1838|issn=0041-1337|doi=10.1097/00007890-199912270-00002}}</ref> | ||
| Line 22: | Line 24: | ||
* Pre-transplant serum [[creatinine]] and total [[bilirubin]] are linearly related to survival. | * Pre-transplant serum [[creatinine]] and total [[bilirubin]] are linearly related to survival. | ||
====Less common risk factors==== | |||
* Use of [[Amiodarone]] pretransplantation | * Use of [[Amiodarone]] pretransplantation | ||
*[[Hypertension]] | *[[Hypertension]] | ||
Revision as of 22:51, 8 July 2020
|
Heart transplantation Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Heart transplantation risk factors On the Web |
|
American Roentgen Ray Society Images of Heart transplantation risk factors |
|
Risk calculators and risk factors for Heart transplantation risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There are no established risk factors that lead to cardiac transplantation. The prognosis of the patient post-transplantation depends on various donor and recipient factors.
Risk Factors
Risk factors for poor outcome post-transplantation can be due to donor-specific characteristics, recipient-specific characteristics, and risk factors due to interactions between the donor and recipient.
Donor factors
Common risk factors
Both the following factors are associated with an increased one-year mortality rate in the recipient.
Recipient factors
- Use of total artificial heart as a bridge to transplant or a need for end-organ support in the form of mechanical ventilation or dialysis- associated with the greatest one-year mortality
- Best prognosis is seen if the indication for transplant is ischemic and nonischemic cardiomyopathy [2]
- Patients with a history of congenital heart disease, restrictive cardiomyopathy, and those undergoing retransplantation have a worse prognosis.
- Younger recipients (below age 55) have an advantage
- Pre-transplant serum creatinine and total bilirubin are linearly related to survival.
Less common risk factors
- Use of Amiodarone pretransplantation
- Hypertension
- Hypercholesterolemia
- Diabetes
- Renal insufficiency
- Use of specific immunosuppressive regimen
- Elevated body mass index
- Tobacco use
- Obesity
- Early post-transplant complications
- Prior cardiac surgery
- Transplantation of a female heart into a male or female recipient
References
- ↑ Potapov, Evgenij V.; Loebe, Matthias; H??bler, Michael; Musci, Michele; Hummel, Manfred; Weng, Yu-guo; Hetzer, Roland (1999). "MEDIUM-TERM RESULTS OF HEART TRANSPLANTATION USING DONORS OVER 63 YEARS OF AGE1". Transplantation. 68 (12): 1834–1838. doi:10.1097/00007890-199912270-00002. ISSN 0041-1337.
- ↑ Khush, Kiran K.; Cherikh, Wida S.; Chambers, Daniel C.; Goldfarb, Samuel; Hayes, Don; Kucheryavaya, Anna Y.; Levvey, Bronwyn J.; Meiser, Bruno; Rossano, Joseph W.; Stehlik, Josef (2018). "The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report—2018; Focus Theme: Multiorgan Transplantation". The Journal of Heart and Lung Transplantation. 37 (10): 1155–1168. doi:10.1016/j.healun.2018.07.022. ISSN 1053-2498.