Epileptic Heart: Difference between revisions

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*Accelerated [[atherosclerotic]] process due to side effect of longstanding [[antiepileptic]] therapy such as [[carbamazepine]], [[gabapentin]] on [[lipid profile]]<ref name="HookanaAnsakorpi2016">{{cite journal|last1=Hookana|first1=Eeva|last2=Ansakorpi|first2=Hanna|last3=Kortelainen|first3=Marja-Leena|last4=Junttila|first4=M. Juhani|last5=Kaikkonen|first5=Kari S|last6=Perkiömäki|first6=Juha|last7=Huikuri|first7=Heikki V|title=Antiepileptic medications and the risk for sudden cardiac death caused by an acute coronary event: a prospective case-control study|journal=Annals of Medicine|volume=48|issue=1-2|year=2016|pages=111–117|issn=0785-3890|doi=10.3109/07853890.2016.1140225}}</ref><ref name="GranbichlerOberaigner2014">{{cite journal|last1=Granbichler|first1=Claudia A.|last2=Oberaigner|first2=Willi|last3=Kuchukhidze|first3=Giorgi|last4=Bauer|first4=Gerhard|last5=Ndayisaba|first5=Jean-Pierre|last6=Seppi|first6=Klaus|last7=Trinka|first7=Eugen|title=Cause-specific mortality in adult epilepsy patients from Tyrol, Austria: hospital-based study|journal=Journal of Neurology|volume=262|issue=1|year=2014|pages=126–133|issn=0340-5354|doi=10.1007/s00415-014-7536-z}}</ref>
*Accelerated [[atherosclerotic]] process due to side effect of longstanding [[antiepileptic]] therapy such as [[carbamazepine]], [[gabapentin]] on [[lipid profile]]<ref name="HookanaAnsakorpi2016">{{cite journal|last1=Hookana|first1=Eeva|last2=Ansakorpi|first2=Hanna|last3=Kortelainen|first3=Marja-Leena|last4=Junttila|first4=M. Juhani|last5=Kaikkonen|first5=Kari S|last6=Perkiömäki|first6=Juha|last7=Huikuri|first7=Heikki V|title=Antiepileptic medications and the risk for sudden cardiac death caused by an acute coronary event: a prospective case-control study|journal=Annals of Medicine|volume=48|issue=1-2|year=2016|pages=111–117|issn=0785-3890|doi=10.3109/07853890.2016.1140225}}</ref><ref name="GranbichlerOberaigner2014">{{cite journal|last1=Granbichler|first1=Claudia A.|last2=Oberaigner|first2=Willi|last3=Kuchukhidze|first3=Giorgi|last4=Bauer|first4=Gerhard|last5=Ndayisaba|first5=Jean-Pierre|last6=Seppi|first6=Klaus|last7=Trinka|first7=Eugen|title=Cause-specific mortality in adult epilepsy patients from Tyrol, Austria: hospital-based study|journal=Journal of Neurology|volume=262|issue=1|year=2014|pages=126–133|issn=0340-5354|doi=10.1007/s00415-014-7536-z}}</ref>
* Increased occurrence of [[arrhythmia]] due to hyperadrenergic state in [[seizure]] episodes<ref name="Baysal-KiracSerbest2017">{{cite journal|last1=Baysal-Kirac|first1=Leyla|last2=Serbest|first2=Nail Güven|last3=Şahin|first3=Erdi|last4=Dede|first4=Hava Özlem|last5=Gürses|first5=Candan|last6=Gökyiğit|first6=Ayşen|last7=Bebek|first7=Nerses|last8=Bilge|first8=Ahmet Kaya|last9=Baykan|first9=Betül|title=Analysis of heart rate variability and risk factors for SUDEP in patients with drug-resistant epilepsy|journal=Epilepsy & Behavior|volume=71|year=2017|pages=60–64|issn=15255050|doi=10.1016/j.yebeh.2017.04.018}}</ref>
*Increased occurrence of [[arrhythmia]] due to hyperadrenergic state in [[seizure]] episodes<ref name="Baysal-KiracSerbest2017">{{cite journal|last1=Baysal-Kirac|first1=Leyla|last2=Serbest|first2=Nail Güven|last3=Şahin|first3=Erdi|last4=Dede|first4=Hava Özlem|last5=Gürses|first5=Candan|last6=Gökyiğit|first6=Ayşen|last7=Bebek|first7=Nerses|last8=Bilge|first8=Ahmet Kaya|last9=Baykan|first9=Betül|title=Analysis of heart rate variability and risk factors for SUDEP in patients with drug-resistant epilepsy|journal=Epilepsy & Behavior|volume=71|year=2017|pages=60–64|issn=15255050|doi=10.1016/j.yebeh.2017.04.018}}</ref>
* Cardiac autonomic dysfunction due to repeated [[siezue]] episodes, a predisposing factor of [[arrhythmia]] <ref name="DeGiorgioMiller2010">{{cite journal|last1=DeGiorgio|first1=Christopher M.|last2=Miller|first2=Patrick|last3=Meymandi|first3=Sheba|last4=Chin|first4=Alex|last5=Epps|first5=Jordan|last6=Gordon|first6=Steven|last7=Gornbein|first7=Jeffrey|last8=Harper|first8=Ronald M.|title=RMSSD, a measure of vagus-mediated heart rate variability, is associated with risk factors for SUDEP: The SUDEP-7 Inventory|journal=Epilepsy & Behavior|volume=19|issue=1|year=2010|pages=78–81|issn=15255050|doi=10.1016/j.yebeh.2010.06.011}}</ref>
*Cardiac autonomic dysfunction due to repeated [[siezue]] episodes, a predisposing factor of [[arrhythmia]] <ref name="DeGiorgioMiller2010">{{cite journal|last1=DeGiorgio|first1=Christopher M.|last2=Miller|first2=Patrick|last3=Meymandi|first3=Sheba|last4=Chin|first4=Alex|last5=Epps|first5=Jordan|last6=Gordon|first6=Steven|last7=Gornbein|first7=Jeffrey|last8=Harper|first8=Ronald M.|title=RMSSD, a measure of vagus-mediated heart rate variability, is associated with risk factors for SUDEP: The SUDEP-7 Inventory|journal=Epilepsy & Behavior|volume=19|issue=1|year=2010|pages=78–81|issn=15255050|doi=10.1016/j.yebeh.2010.06.011}}</ref>
* [[Arrhythmogenic]] effect of [[antiepileptic]] drugs due to blockage of [[sodium channels ]] on [[heart]]
*[[Arrhythmogenic]] effect of [[antiepileptic]] drugs due to blockage of [[sodium channels ]] on [[heart]]
* Susceptibility  to [[ventricular fibrillation]] before or after [[seizure]] episods<ref name="KiechlBardai2012">{{cite journal|last1=Kiechl|first1=Stefan|last2=Bardai|first2=Abdennasser|last3=Lamberts|first3=Robert J.|last4=Blom|first4=Marieke T.|last5=Spanjaart|first5=Anne M.|last6=Berdowski|first6=Jocelyn|last7=van der Staal|first7=Sebastiaan R.|last8=Brouwer|first8=Henk J.|last9=Koster|first9=Rudolph W.|last10=Sander|first10=Josemir W.|last11=Thijs|first11=Roland D.|last12=Tan|first12=Hanno L.|title=Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population|journal=PLoS ONE|volume=7|issue=8|year=2012|pages=e42749|issn=1932-6203|doi=10.1371/journal.pone.0042749}}</ref>
*Susceptibility  to [[ventricular fibrillation]] before or after [[seizure]] episods<ref name="KiechlBardai2012">{{cite journal|last1=Kiechl|first1=Stefan|last2=Bardai|first2=Abdennasser|last3=Lamberts|first3=Robert J.|last4=Blom|first4=Marieke T.|last5=Spanjaart|first5=Anne M.|last6=Berdowski|first6=Jocelyn|last7=van der Staal|first7=Sebastiaan R.|last8=Brouwer|first8=Henk J.|last9=Koster|first9=Rudolph W.|last10=Sander|first10=Josemir W.|last11=Thijs|first11=Roland D.|last12=Tan|first12=Hanno L.|title=Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population|journal=PLoS ONE|volume=7|issue=8|year=2012|pages=e42749|issn=1932-6203|doi=10.1371/journal.pone.0042749}}</ref>
* Structural [[myocardium]] damage due to repeated [[seizures]], such as [[myocardial]] calcified lesions, myocardial stiffness, [[cardiomegaly]], [[ventricular hypertrophy]], [[left artial dilation]]<ref name="FineschiSilver2005">{{cite journal|last1=Fineschi|first1=V.|last2=Silver|first2=M.D.|last3=Karch|first3=S.B.|last4=Parolini|first4=M.|last5=Turillazzi|first5=E.|last6=Pomara|first6=C.|last7=Baroldi|first7=G.|title=Myocardial disarray: an architectural disorganization linked with adrenergic stress?|journal=International Journal of Cardiology|volume=99|issue=2|year=2005|pages=277–282|issn=01675273|doi=10.1016/j.ijcard.2004.01.022}}</ref><ref name="ZhaoZhang2019">{{cite journal|last1=Zhao|first1=Haiting|last2=Zhang|first2=Honghai|last3=Schoen|first3=Frederick J.|last4=Schachter|first4=Steven C.|last5=Feng|first5=Hua-Jun|title=Repeated generalized seizures can produce calcified cardiac lesions in DBA/1 mice|journal=Epilepsy & Behavior|volume=95|year=2019|pages=169–174|issn=15255050|doi=10.1016/j.yebeh.2019.04.010}}</ref>
*Structural [[myocardium]] damage due to repeated [[seizures]], such as [[myocardial]] calcified lesions, myocardial stiffness, [[cardiomegaly]], [[ventricular hypertrophy]], [[left artial dilation]]<ref name="FineschiSilver2005">{{cite journal|last1=Fineschi|first1=V.|last2=Silver|first2=M.D.|last3=Karch|first3=S.B.|last4=Parolini|first4=M.|last5=Turillazzi|first5=E.|last6=Pomara|first6=C.|last7=Baroldi|first7=G.|title=Myocardial disarray: an architectural disorganization linked with adrenergic stress?|journal=International Journal of Cardiology|volume=99|issue=2|year=2005|pages=277–282|issn=01675273|doi=10.1016/j.ijcard.2004.01.022}}</ref><ref name="ZhaoZhang2019">{{cite journal|last1=Zhao|first1=Haiting|last2=Zhang|first2=Honghai|last3=Schoen|first3=Frederick J.|last4=Schachter|first4=Steven C.|last5=Feng|first5=Hua-Jun|title=Repeated generalized seizures can produce calcified cardiac lesions in DBA/1 mice|journal=Epilepsy & Behavior|volume=95|year=2019|pages=169–174|issn=15255050|doi=10.1016/j.yebeh.2019.04.010}}</ref>
*Neurogenic stunned myocardium similar to [[tukotsubo]], a reversible [[cardiomyopathy]] after a [[seizure]] episode<ref name="ChinBranch2005">{{cite journal|last1=Chin|first1=P. S.|last2=Branch|first2=K. R.|last3=Becker|first3=K. J.|title=Postictal neurogenic stunned myocardium|journal=Neurology|volume=64|issue=11|year=2005|pages=1977–1978|issn=0028-3878|doi=10.1212/01.WNL.0000163858.77494.7A}}</ref>
*Neurogenic stunned myocardium similar to [[tukotsubo]], a reversible [[cardiomyopathy]] after a [[seizure]] episode<ref name="ChinBranch2005">{{cite journal|last1=Chin|first1=P. S.|last2=Branch|first2=K. R.|last3=Becker|first3=K. J.|title=Postictal neurogenic stunned myocardium|journal=Neurology|volume=64|issue=11|year=2005|pages=1977–1978|issn=0028-3878|doi=10.1212/01.WNL.0000163858.77494.7A}}</ref>
* Increased occurrence of [[atrial fibrillation ]] after [[seizure]] episode<ref name="NaylorChurilov2018">{{cite journal|last1=Naylor|first1=Jillian|last2=Churilov|first2=Leonid|last3=Johnstone|first3=Benjamin|last4=Guo|first4=Ruibing|last5=Xiong|first5=Yunyun|last6=Koome|first6=Miriam|last7=Chen|first7=Ziyi|last8=Thevathasan|first8=Arthur|last9=Chen|first9=Ziyuan|last10=Liu|first10=Xinfeng|last11=Kwan|first11=Patrick|last12=Campbell|first12=Bruce C.V.|title=The Association Between Atrial Fibrillation and Poststroke Seizures is Influenced by Ethnicity and Environmental Factors|journal=Journal of Stroke and Cerebrovascular Diseases|volume=27|issue=10|year=2018|pages=2755–2760|issn=10523057|doi=10.1016/j.jstrokecerebrovasdis.2018.05.044}}</ref>
*Increased occurrence of [[atrial fibrillation ]] after [[seizure]] episode<ref name="NaylorChurilov2018">{{cite journal|last1=Naylor|first1=Jillian|last2=Churilov|first2=Leonid|last3=Johnstone|first3=Benjamin|last4=Guo|first4=Ruibing|last5=Xiong|first5=Yunyun|last6=Koome|first6=Miriam|last7=Chen|first7=Ziyi|last8=Thevathasan|first8=Arthur|last9=Chen|first9=Ziyuan|last10=Liu|first10=Xinfeng|last11=Kwan|first11=Patrick|last12=Campbell|first12=Bruce C.V.|title=The Association Between Atrial Fibrillation and Poststroke Seizures is Influenced by Ethnicity and Environmental Factors|journal=Journal of Stroke and Cerebrovascular Diseases|volume=27|issue=10|year=2018|pages=2755–2760|issn=10523057|doi=10.1016/j.jstrokecerebrovasdis.2018.05.044}}</ref>


==Differentiating [[epileptic heart]] from other Diseases==
==Differentiating [[epileptic heart]] from other Diseases==
*[[Epileptic heart]]  must be differentiated from other diseases that cause  [[loss of consciousness]] or [[sudden death]]  such as:
*[[Epileptic heart]]  must be differentiated from other diseases that cause  [[loss of consciousness]] or [[sudden death]]  such as:
:*Sudden unexpected death in epilepsy( SUDEP)
:*Sudden unexpected death in epilepsy( SUDEP)
:*[[Convulsion syncope]]
:*[[Convulsion syncope]]
:*[[Epileptic seizure]]
:*[[Epileptic seizure]]
{| style="border: 2px solid #4479BA; align="left"
 
! style="width: 200px; background: #4479BA;" | {{fontcolor|#FFF|[[Epileptic heart]]}}
{| style="border: 2px solid #4479BA; align=" left"
! style="width: 300px; background: #4479BA;" | {{fontcolor|#FFF|[[Sudden unexpected death in epilepsy]] [[SUDEP]]}}
! style="width: 200px; background: #4479BA;" |{{fontcolor|#FFF|[[Epileptic heart]]}}
! style="width: 300px; background: #4479BA;" | {{fontcolor|#FFF|[[Convulsion syncope]]}}
! style="width: 300px; background: #4479BA;" |{{fontcolor|#FFF|[[Sudden unexpected death in epilepsy]] [[SUDEP]]}}
! style="width: 300px; background: #4479BA;" | {{fontcolor|#FFF|[[Epileptic seizure]]}}
! style="width: 300px; background: #4479BA;" |{{fontcolor|#FFF|[[Convulsion syncope]]}}
! style="width: 300px; background: #4479BA;" |{{fontcolor|#FFF|[[Epileptic seizure]]}}
|-
|-
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* Structural and functional heart disease as a result of autonomous dysfunction of the [[heart]] due to the longstanding effect of [[seizure]] episodes on the [[heart]]  
*Structural and functional heart disease as a result of autonomous dysfunction of the [[heart]] due to the longstanding effect of [[seizure]] episodes on the [[heart]]
*Increased occurrence of [[sudden cardiac death]] related or unrelated to [[siezue]] episodes in older age> 40 years<ref name="ZackLuncheon2018">{{cite journal|last1=Zack|first1=Matthew|last2=Luncheon|first2=Cecily|title=Adults with an epilepsy history, notably those 45–64 years old or at the lowest income levels, more often report heart disease than adults without an epilepsy history|journal=Epilepsy & Behavior|volume=86|year=2018|pages=208–210|issn=15255050|doi=10.1016/j.yebeh.2018.05.021}}</ref>
*Increased occurrence of [[sudden cardiac death]] related or unrelated to [[siezue]] episodes in older age> 40 years<ref name="ZackLuncheon2018">{{cite journal|last1=Zack|first1=Matthew|last2=Luncheon|first2=Cecily|title=Adults with an epilepsy history, notably those 45–64 years old or at the lowest income levels, more often report heart disease than adults without an epilepsy history|journal=Epilepsy & Behavior|volume=86|year=2018|pages=208–210|issn=15255050|doi=10.1016/j.yebeh.2018.05.021}}</ref>
*Increased occurrence of [[coronary artery disease]] in earlier age ( mean age:55-year-old) compared with patients without [[epilepsy]]( mean age:69 year old)
*Increased occurrence of [[coronary artery disease]] in earlier age ( mean age:55-year-old) compared with patients without [[epilepsy]]( mean age:69 year old)
* [[Myocardial injury ]] due to  repeated [[sympathetic]] stimulation of [[seizure]] episodes  
*[[Myocardial injury ]] due to  repeated [[sympathetic]] stimulation of [[seizure]] episodes
*[[Hypertrophy]] in the ventricular myocardium
*[[Hypertrophy]] in the ventricular myocardium
*Increased occurrence of [[arrhythmia]] due to conduction, [[repolarization abnormality]], [[cardiac electerical instability]]  
*Increased occurrence of [[arrhythmia]] due to conduction, [[repolarization abnormality]], [[cardiac electerical instability]]
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*[[Sudden death]] related to [[pulmonary dysfunction]] and [[apnea]] in the [[postictal period]]<ref name="NashefSo2012">{{cite journal|last1=Nashef|first1=Lina|last2=So|first2=Elson L.|last3=Ryvlin|first3=Philippe|last4=Tomson|first4=Torbjörn|title=Unifying the definitions of sudden unexpected death in epilepsy|journal=Epilepsia|volume=53|issue=2|year=2012|pages=227–233|issn=00139580|doi=10.1111/j.1528-1167.2011.03358.x}}</ref>
*[[Sudden death]] related to [[pulmonary dysfunction]] and [[apnea]] in the [[postictal period]]<ref name="NashefSo2012">{{cite journal|last1=Nashef|first1=Lina|last2=So|first2=Elson L.|last3=Ryvlin|first3=Philippe|last4=Tomson|first4=Torbjörn|title=Unifying the definitions of sudden unexpected death in epilepsy|journal=Epilepsia|volume=53|issue=2|year=2012|pages=227–233|issn=00139580|doi=10.1111/j.1528-1167.2011.03358.x}}</ref>


* Not categorized as [[sudden cardiac death]]  
*Not categorized as [[sudden cardiac death]]
* Common age:20-40 years old<ref name="TomsonWalczak2005">{{cite journal|last1=Tomson|first1=Torbjorn|last2=Walczak|first2=Ted|last3=Sillanpaa|first3=Matti|last4=Sander|first4=Josemir W. A. S.|title=Sudden Unexpected Death in Epilepsy: A Review of Incidence and Risk Factors|journal=Epilepsia|volume=46|issue=s11|year=2005|pages=54–61|issn=0013-9580|doi=10.1111/j.1528-1167.2005.00411.x}}</ref>
*Common age:20-40 years old<ref name="TomsonWalczak2005">{{cite journal|last1=Tomson|first1=Torbjorn|last2=Walczak|first2=Ted|last3=Sillanpaa|first3=Matti|last4=Sander|first4=Josemir W. A. S.|title=Sudden Unexpected Death in Epilepsy: A Review of Incidence and Risk Factors|journal=Epilepsia|volume=46|issue=s11|year=2005|pages=54–61|issn=0013-9580|doi=10.1111/j.1528-1167.2005.00411.x}}</ref>


*Risk factors: [[youth]], early age at [[seizure]] onset, Presence of [[generalized tonic clonic seizure]], [[male]], being in bed at the time of [[death]]<ref name="SurgesThijs2009">{{cite journal|last1=Surges|first1=Rainer|last2=Thijs|first2=Roland D.|last3=Tan|first3=Hanno L.|last4=Sander|first4=Josemir W.|title=Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms|journal=Nature Reviews Neurology|volume=5|issue=9|year=2009|pages=492–504|issn=1759-4758|doi=10.1038/nrneurol.2009.118}}</ref>
*Risk factors: [[youth]], early age at [[seizure]] onset, Presence of [[generalized tonic clonic seizure]], [[male]], being in bed at the time of [[death]]<ref name="SurgesThijs2009">{{cite journal|last1=Surges|first1=Rainer|last2=Thijs|first2=Roland D.|last3=Tan|first3=Hanno L.|last4=Sander|first4=Josemir W.|title=Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms|journal=Nature Reviews Neurology|volume=5|issue=9|year=2009|pages=492–504|issn=1759-4758|doi=10.1038/nrneurol.2009.118}}</ref>


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* [[Cardiac]] [[syncope]] and [[seizure]] preceding each other
*[[Cardiac]] [[syncope]] and [[seizure]] preceding each other
* [[Cardiac]] [[syncope]] definition: brief, reversible, [[transient loss of consciousness]] due to [[cerebral hypoperfusion]] following [[reflex mediated syncope]], [[structural heart disease]], [[arrhythmia]], [[orthostasis hypotension]]
*[[Cardiac]] [[syncope]] definition: brief, reversible, [[transient loss of consciousness]] due to [[cerebral hypoperfusion]] following [[reflex mediated syncope]], [[structural heart disease]], [[arrhythmia]], [[orthostasis hypotension]]
*[[Seizure]] preceding  ictal [[sinus tachycardia]], [[ventricular fibrillation]], [[bradycardia]],[[asystole]]<ref name="ReevesNollet1996">{{cite journal|last1=Reeves|first1=Andrew L.|last2=Nollet|first2=Kenneth E.|last3=Klass|first3=Donald W.|last4=Sharbrough|first4=Frank W.|last5=So|first5=Elson L.|title=The Ictal Bradycardia Syndrome|journal=Epilepsia|volume=37|issue=10|year=1996|pages=983–987|issn=0013-9580|doi=10.1111/j.1528-1157.1996.tb00536.x}}</ref>
*[[Seizure]] preceding  ictal [[sinus tachycardia]], [[ventricular fibrillation]], [[bradycardia]],[[asystole]]<ref name="ReevesNollet1996">{{cite journal|last1=Reeves|first1=Andrew L.|last2=Nollet|first2=Kenneth E.|last3=Klass|first3=Donald W.|last4=Sharbrough|first4=Frank W.|last5=So|first5=Elson L.|title=The Ictal Bradycardia Syndrome|journal=Epilepsia|volume=37|issue=10|year=1996|pages=983–987|issn=0013-9580|doi=10.1111/j.1528-1157.1996.tb00536.x}}</ref>
*[[Arrhythmia]] preceding [[seizure]]
*[[Arrhythmia]] preceding [[seizure]]
* Identifying same genes mutation in [[brain]] and [[cardiac]] leading to [[epilepsy]] and [[arrhythmia]]<ref name="NashefWalker1996">{{cite journal|last1=Nashef|first1=L|last2=Walker|first2=F|last3=Allen|first3=P|last4=Sander|first4=J W|last5=Shorvon|first5=S D|last6=Fish|first6=D R|title=Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy.|journal=Journal of Neurology, Neurosurgery & Psychiatry|volume=60|issue=3|year=1996|pages=297–300|issn=0022-3050|doi=10.1136/jnnp.60.3.297}}</ref>
*Identifying same genes mutation in [[brain]] and [[cardiac]] leading to [[epilepsy]] and [[arrhythmia]]<ref name="NashefWalker1996">{{cite journal|last1=Nashef|first1=L|last2=Walker|first2=F|last3=Allen|first3=P|last4=Sander|first4=J W|last5=Shorvon|first5=S D|last6=Fish|first6=D R|title=Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy.|journal=Journal of Neurology, Neurosurgery & Psychiatry|volume=60|issue=3|year=1996|pages=297–300|issn=0022-3050|doi=10.1136/jnnp.60.3.297}}</ref>


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*[[Transient loss of consciousness]] due to abnormal neuronal discharge in the [[brain]]  
*[[Transient loss of consciousness]] due to abnormal neuronal discharge in the [[brain]]
*Repetitive
*Repetitive


* High frequency of misdiagnosis with [[cardiac syncope]]
*High frequency of misdiagnosis with [[cardiac syncope]]
*[[Tongue biting]]
*[[Tongue biting]]
*[[Sense of deja vu]] or [[jamais vu]] before spells, preoccupation, [[hallucination]],[[ mood changes]], [[somatosensory auras]], [[trembling]]
*[[Sense of deja vu]] or [[jamais vu]] before spells, preoccupation, [[hallucination]],[[ mood changes]], [[somatosensory auras]], [[trembling]]
* [[Unusual posturing]], [[Jerking limbs]]
*[[Unusual posturing]], [[Jerking limbs]]
*[[Blue face]], [[acrocyanosis]]
*[[Blue face]], [[acrocyanosis]]
*Postictall blurred period
*Postictall blurred period
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==Epidemiology and Demographics==
==Epidemiology and Demographics==
* The incidence of heart disease such as [[coronary artery disease]], [[heart attack]] in patients with epilepsy is approximately 25600 per 100,000 individuals between 45-64 years old. This amount in patients without [[epilepsy]] is 11500 per 100,000 individuals between 45-64 years old..<ref name="ZackLuncheon2018">{{cite journal|last1=Zack|first1=Matthew|last2=Luncheon|first2=Cecily|title=Adults with an epilepsy history, notably those 45–64 years old or at the lowest income levels, more often report heart disease than adults without an epilepsy history|journal=Epilepsy & Behavior|volume=86|year=2018|pages=208–210|issn=15255050|doi=10.1016/j.yebeh.2018.05.021}}</ref>
 
* In 2018, the incidence of [[sudden cardiac death ]] in epileptic patients was estimated to be 4400 cases per 100,000 individuals in the united states which was 4.5 fold of [[SUDEP]] cases.<ref name="BenjaminVirani2018">{{cite journal|last1=Benjamin|first1=Emelia J.|last2=Virani|first2=Salim S.|last3=Callaway|first3=Clifton W.|last4=Chamberlain|first4=Alanna M.|last5=Chang|first5=Alexander R.|last6=Cheng|first6=Susan|last7=Chiuve|first7=Stephanie E.|last8=Cushman|first8=Mary|last9=Delling|first9=Francesca N.|last10=Deo|first10=Rajat|last11=de Ferranti|first11=Sarah D.|last12=Ferguson|first12=Jane F.|last13=Fornage|first13=Myriam|last14=Gillespie|first14=Cathleen|last15=Isasi|first15=Carmen R.|last16=Jiménez|first16=Monik C.|last17=Jordan|first17=Lori Chaffin|last18=Judd|first18=Suzanne E.|last19=Lackland|first19=Daniel|last20=Lichtman|first20=Judith H.|last21=Lisabeth|first21=Lynda|last22=Liu|first22=Simin|last23=Longenecker|first23=Chris T.|last24=Lutsey|first24=Pamela L.|last25=Mackey|first25=Jason S.|last26=Matchar|first26=David B.|last27=Matsushita|first27=Kunihiro|last28=Mussolino|first28=Michael E.|last29=Nasir|first29=Khurram|last30=O’Flaherty|first30=Martin|last31=Palaniappan|first31=Latha P.|last32=Pandey|first32=Ambarish|last33=Pandey|first33=Dilip K.|last34=Reeves|first34=Mathew J.|last35=Ritchey|first35=Matthew D.|last36=Rodriguez|first36=Carlos J.|last37=Roth|first37=Gregory A.|last38=Rosamond|first38=Wayne D.|last39=Sampson|first39=Uchechukwu K.A.|last40=Satou|first40=Gary M.|last41=Shah|first41=Svati H.|last42=Spartano|first42=Nicole L.|last43=Tirschwell|first43=David L.|last44=Tsao|first44=Connie W.|last45=Voeks|first45=Jenifer H.|last46=Willey|first46=Joshua Z.|last47=Wilkins|first47=John T.|last48=Wu|first48=Jason HY.|last49=Alger|first49=Heather M.|last50=Wong|first50=Sally S.|last51=Muntner|first51=Paul|title=Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association|journal=Circulation|volume=137|issue=12|year=2018|issn=0009-7322|doi=10.1161/CIR.0000000000000558}}</ref>
*The incidence of heart disease such as [[coronary artery disease]], [[heart attack]] in patients with epilepsy is approximately 25600 per 100,000 individuals between 45-64 years old. This amount in patients without [[epilepsy]] is 11500 per 100,000 individuals between 45-64 years old..<ref name="ZackLuncheon2018">{{cite journal|last1=Zack|first1=Matthew|last2=Luncheon|first2=Cecily|title=Adults with an epilepsy history, notably those 45–64 years old or at the lowest income levels, more often report heart disease than adults without an epilepsy history|journal=Epilepsy & Behavior|volume=86|year=2018|pages=208–210|issn=15255050|doi=10.1016/j.yebeh.2018.05.021}}</ref>
*In 2018, the incidence of [[sudden cardiac death ]] in epileptic patients was estimated to be 4400 cases per 100,000 individuals in the united states which was 4.5 fold of [[SUDEP]] cases.<ref name="BenjaminVirani2018">{{cite journal|last1=Benjamin|first1=Emelia J.|last2=Virani|first2=Salim S.|last3=Callaway|first3=Clifton W.|last4=Chamberlain|first4=Alanna M.|last5=Chang|first5=Alexander R.|last6=Cheng|first6=Susan|last7=Chiuve|first7=Stephanie E.|last8=Cushman|first8=Mary|last9=Delling|first9=Francesca N.|last10=Deo|first10=Rajat|last11=de Ferranti|first11=Sarah D.|last12=Ferguson|first12=Jane F.|last13=Fornage|first13=Myriam|last14=Gillespie|first14=Cathleen|last15=Isasi|first15=Carmen R.|last16=Jiménez|first16=Monik C.|last17=Jordan|first17=Lori Chaffin|last18=Judd|first18=Suzanne E.|last19=Lackland|first19=Daniel|last20=Lichtman|first20=Judith H.|last21=Lisabeth|first21=Lynda|last22=Liu|first22=Simin|last23=Longenecker|first23=Chris T.|last24=Lutsey|first24=Pamela L.|last25=Mackey|first25=Jason S.|last26=Matchar|first26=David B.|last27=Matsushita|first27=Kunihiro|last28=Mussolino|first28=Michael E.|last29=Nasir|first29=Khurram|last30=O’Flaherty|first30=Martin|last31=Palaniappan|first31=Latha P.|last32=Pandey|first32=Ambarish|last33=Pandey|first33=Dilip K.|last34=Reeves|first34=Mathew J.|last35=Ritchey|first35=Matthew D.|last36=Rodriguez|first36=Carlos J.|last37=Roth|first37=Gregory A.|last38=Rosamond|first38=Wayne D.|last39=Sampson|first39=Uchechukwu K.A.|last40=Satou|first40=Gary M.|last41=Shah|first41=Svati H.|last42=Spartano|first42=Nicole L.|last43=Tirschwell|first43=David L.|last44=Tsao|first44=Connie W.|last45=Voeks|first45=Jenifer H.|last46=Willey|first46=Joshua Z.|last47=Wilkins|first47=John T.|last48=Wu|first48=Jason HY.|last49=Alger|first49=Heather M.|last50=Wong|first50=Sally S.|last51=Muntner|first51=Paul|title=Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association|journal=Circulation|volume=137|issue=12|year=2018|issn=0009-7322|doi=10.1161/CIR.0000000000000558}}</ref>
*The incidence of [[heart disease]] in patients with [[epilepsy]] was 9% higher than patients without [[epilepsy]].<ref name="ZackLuncheon2018">{{cite journal|last1=Zack|first1=Matthew|last2=Luncheon|first2=Cecily|title=Adults with an epilepsy history, notably those 45–64 years old or at the lowest income levels, more often report heart disease than adults without an epilepsy history|journal=Epilepsy & Behavior|volume=86|year=2018|pages=208–210|issn=15255050|doi=10.1016/j.yebeh.2018.05.021}}</ref>
*The incidence of [[heart disease]] in patients with [[epilepsy]] was 9% higher than patients without [[epilepsy]].<ref name="ZackLuncheon2018">{{cite journal|last1=Zack|first1=Matthew|last2=Luncheon|first2=Cecily|title=Adults with an epilepsy history, notably those 45–64 years old or at the lowest income levels, more often report heart disease than adults without an epilepsy history|journal=Epilepsy & Behavior|volume=86|year=2018|pages=208–210|issn=15255050|doi=10.1016/j.yebeh.2018.05.021}}</ref>
   
   
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===Race===
===Race===
*There is no racial predilection for epileptic heart.
*There is no racial predilection for epileptic heart.


==Risk Factors==
==Risk Factors==
*Common risk factors in the development of [[epileptic heart]] may include:
*Common risk factors in the development of [[epileptic heart]] may include:
*Low [[socioeconomic status]]
*Low [[socioeconomic status]]
*Long standing [[antiepileptic]] therapy  
*Long standing [[antiepileptic]] therapy
*[[Hypertension]]
*[[Hypertension]]
*[[Hyperlipidemia]]
*[[Hyperlipidemia]]
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*Aging
*Aging
*Progression of underlying cardiac disease
*Progression of underlying cardiac disease
==Screening==
==Screening==
Currently, there is no guideline statement that recommends routine cardiac evaluation of patients with epilepsy. However, a resting 12-lead EKG and/or ambulatory EKG patch recording may be useful in identifying the patients at risk of cardiac pathology and further follow the progression of their cardiac pathology.<ref name="VerrierPang2020">{{cite journal|last1=Verrier|first1=Richard L.|last2=Pang|first2=Trudy D.|last3=Nearing|first3=Bruce D.|last4=Schachter|first4=Steven C.|title=The Epileptic Heart: Concept and clinical evidence|journal=Epilepsy & Behavior|volume=105|year=2020|pages=106946|issn=15255050|doi=10.1016/j.yebeh.2020.106946}}</ref>
Currently, there is no guideline statement that recommended routine [[cardiac]] evaluation of [[patients]] with [[epilepsy]]. However, a resting 12-lead [[EKG]] and/or ambulatory [[EKG]] patch recording may be useful in identifying the [[patients]] at risk of [[cardiac]] pathology and further follow the progression of their [[cardiac]] pathology.<ref name="VerrierPang2020">{{cite journal|last1=Verrier|first1=Richard L.|last2=Pang|first2=Trudy D.|last3=Nearing|first3=Bruce D.|last4=Schachter|first4=Steven C.|title=The Epileptic Heart: Concept and clinical evidence|journal=Epilepsy & Behavior|volume=105|year=2020|pages=106946|issn=15255050|doi=10.1016/j.yebeh.2020.106946}}</ref>
== Natural History, Complications and Prognosis==
==Natural History, Complications and Prognosis==
*Patients with [[epileptic heart]] suffer from chronic [[epilepsy]] and [[antiepileptic drug]] resistance for many years.  
 
*Patients with [[epileptic heart]] suffer from chronic [[epilepsy]] and [[antiepileptic drug]] resistance for many years.
*Early clinical features include manifestation related to [[cardiac involvement]] such as [[syncope]], [[chest discomfort]], [[exertional dyspnea]], [[palpitation]].
*Early clinical features include manifestation related to [[cardiac involvement]] such as [[syncope]], [[chest discomfort]], [[exertional dyspnea]], [[palpitation]].
*Patients with chronic [[epilepsy]] may progress to develop complications of [[arrhythmia]] and [[myocardial ischemia]].
*Patients with chronic [[epilepsy]] may progress to develop complications of [[arrhythmia]] and [[myocardial ischemia]].
*Common complications of the epileptic [[heart]] include [[coronary artery disease]], [[heart failure]], [[sudden cardiac arrest]], [[sudden cardiac death]].  
*Common complications of the epileptic [[heart]] include [[coronary artery disease]], [[heart failure]], [[sudden cardiac arrest]], [[sudden cardiac death]].
*Prognosis is generally poor, and the 1-year mortality of patients with chronic [[epilepsy]] due to [[sudden cardiac death]] is approximately 4.4%.<ref name="BenjaminVirani2018">{{cite journal|last1=Benjamin|first1=Emelia J.|last2=Virani|first2=Salim S.|last3=Callaway|first3=Clifton W.|last4=Chamberlain|first4=Alanna M.|last5=Chang|first5=Alexander R.|last6=Cheng|first6=Susan|last7=Chiuve|first7=Stephanie E.|last8=Cushman|first8=Mary|last9=Delling|first9=Francesca N.|last10=Deo|first10=Rajat|last11=de Ferranti|first11=Sarah D.|last12=Ferguson|first12=Jane F.|last13=Fornage|first13=Myriam|last14=Gillespie|first14=Cathleen|last15=Isasi|first15=Carmen R.|last16=Jiménez|first16=Monik C.|last17=Jordan|first17=Lori Chaffin|last18=Judd|first18=Suzanne E.|last19=Lackland|first19=Daniel|last20=Lichtman|first20=Judith H.|last21=Lisabeth|first21=Lynda|last22=Liu|first22=Simin|last23=Longenecker|first23=Chris T.|last24=Lutsey|first24=Pamela L.|last25=Mackey|first25=Jason S.|last26=Matchar|first26=David B.|last27=Matsushita|first27=Kunihiro|last28=Mussolino|first28=Michael E.|last29=Nasir|first29=Khurram|last30=O’Flaherty|first30=Martin|last31=Palaniappan|first31=Latha P.|last32=Pandey|first32=Ambarish|last33=Pandey|first33=Dilip K.|last34=Reeves|first34=Mathew J.|last35=Ritchey|first35=Matthew D.|last36=Rodriguez|first36=Carlos J.|last37=Roth|first37=Gregory A.|last38=Rosamond|first38=Wayne D.|last39=Sampson|first39=Uchechukwu K.A.|last40=Satou|first40=Gary M.|last41=Shah|first41=Svati H.|last42=Spartano|first42=Nicole L.|last43=Tirschwell|first43=David L.|last44=Tsao|first44=Connie W.|last45=Voeks|first45=Jenifer H.|last46=Willey|first46=Joshua Z.|last47=Wilkins|first47=John T.|last48=Wu|first48=Jason HY.|last49=Alger|first49=Heather M.|last50=Wong|first50=Sally S.|last51=Muntner|first51=Paul|title=Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association|journal=Circulation|volume=137|issue=12|year=2018|issn=0009-7322|doi=10.1161/CIR.0000000000000558}}</ref>
*Prognosis is generally poor, and the 1-year mortality of patients with chronic [[epilepsy]] due to [[sudden cardiac death]] is approximately 4.4%.<ref name="BenjaminVirani2018">{{cite journal|last1=Benjamin|first1=Emelia J.|last2=Virani|first2=Salim S.|last3=Callaway|first3=Clifton W.|last4=Chamberlain|first4=Alanna M.|last5=Chang|first5=Alexander R.|last6=Cheng|first6=Susan|last7=Chiuve|first7=Stephanie E.|last8=Cushman|first8=Mary|last9=Delling|first9=Francesca N.|last10=Deo|first10=Rajat|last11=de Ferranti|first11=Sarah D.|last12=Ferguson|first12=Jane F.|last13=Fornage|first13=Myriam|last14=Gillespie|first14=Cathleen|last15=Isasi|first15=Carmen R.|last16=Jiménez|first16=Monik C.|last17=Jordan|first17=Lori Chaffin|last18=Judd|first18=Suzanne E.|last19=Lackland|first19=Daniel|last20=Lichtman|first20=Judith H.|last21=Lisabeth|first21=Lynda|last22=Liu|first22=Simin|last23=Longenecker|first23=Chris T.|last24=Lutsey|first24=Pamela L.|last25=Mackey|first25=Jason S.|last26=Matchar|first26=David B.|last27=Matsushita|first27=Kunihiro|last28=Mussolino|first28=Michael E.|last29=Nasir|first29=Khurram|last30=O’Flaherty|first30=Martin|last31=Palaniappan|first31=Latha P.|last32=Pandey|first32=Ambarish|last33=Pandey|first33=Dilip K.|last34=Reeves|first34=Mathew J.|last35=Ritchey|first35=Matthew D.|last36=Rodriguez|first36=Carlos J.|last37=Roth|first37=Gregory A.|last38=Rosamond|first38=Wayne D.|last39=Sampson|first39=Uchechukwu K.A.|last40=Satou|first40=Gary M.|last41=Shah|first41=Svati H.|last42=Spartano|first42=Nicole L.|last43=Tirschwell|first43=David L.|last44=Tsao|first44=Connie W.|last45=Voeks|first45=Jenifer H.|last46=Willey|first46=Joshua Z.|last47=Wilkins|first47=John T.|last48=Wu|first48=Jason HY.|last49=Alger|first49=Heather M.|last50=Wong|first50=Sally S.|last51=Muntner|first51=Paul|title=Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association|journal=Circulation|volume=137|issue=12|year=2018|issn=0009-7322|doi=10.1161/CIR.0000000000000558}}</ref>


== Diagnosis ==
==Diagnosis==
===Diagnostic Criteria===
===Diagnostic Criteria===
*The diagnosis of the epileptic heart is made when the following  diagnostic criteria are met:
*The diagnosis of the epileptic heart is made when the following  diagnostic criteria are met:
:* Resistant [[epilepsy]]
 
:* Longstanding use of [[antiepileptic]] drugs
:*Resistant [[epilepsy]]
:*Longstanding use of [[antiepileptic]] drugs
:*Presence of  arrhythmia syncope and high level of [[T waves]] alternance  as a marker of [[repolarization abnormality]] and [[ventricular fibrillation]] on [[ECG]]
:*Presence of  arrhythmia syncope and high level of [[T waves]] alternance  as a marker of [[repolarization abnormality]] and [[ventricular fibrillation]] on [[ECG]]
:* Presence of [[ischemic heart disease]] earlier than the common age  
:*Presence of [[ischemic heart disease]] earlier than the common age
:* Evidence of [[myocardial injury]] such as  high level of [[troponin I]]<ref name="NassMotloch2019">{{cite journal|last1=Nass|first1=Robert D.|last2=Motloch|first2=Lukas J.|last3=Paar|first3=Vera|last4=Lichtenauer|first4=Michael|last5=Baumann|first5=Jan|last6=Zur|first6=Berndt|last7=Hoppe|first7=Uta C.|last8=Holdenrieder|first8=Stefan|last9=Elger|first9=Christian E.|last10=Surges|first10=Rainer|title=Blood markers of cardiac stress after generalized convulsive seizures|journal=Epilepsia|volume=60|issue=2|year=2019|pages=201–210|issn=0013-9580|doi=10.1111/epi.14637}}</ref>
:*Evidence of [[myocardial injury]] such as  high level of [[troponin I]]<ref name="NassMotloch2019">{{cite journal|last1=Nass|first1=Robert D.|last2=Motloch|first2=Lukas J.|last3=Paar|first3=Vera|last4=Lichtenauer|first4=Michael|last5=Baumann|first5=Jan|last6=Zur|first6=Berndt|last7=Hoppe|first7=Uta C.|last8=Holdenrieder|first8=Stefan|last9=Elger|first9=Christian E.|last10=Surges|first10=Rainer|title=Blood markers of cardiac stress after generalized convulsive seizures|journal=Epilepsia|volume=60|issue=2|year=2019|pages=201–210|issn=0013-9580|doi=10.1111/epi.14637}}</ref>
 


===History and Symptoms===


=== History and Symptoms ===
*Symptoms of the [[epileptic heart]] may include the following:
*Symptoms of the [[epileptic heart]] may include the following:
:*Abrupt [[palpitation]]
:*Abrupt [[palpitation]]
:* [[Shortness of breath]]
:*[[Shortness of breath]]
:* [[Angina pectori]]
:*[[Angina pectori]]
:* [[lightheadness]]
:*[[lightheadness]]
:* [[Dizziness]]
:*[[Dizziness]]
:* [[Falling]]
:*[[Falling]]
:* [[Near falling]]
:*[[Near falling]]
 
===Physical Examination===


=== Physical Examination ===
*Physical examination associated with [[epilepsy]] include:
*Physical examination associated with [[epilepsy]] include:
:* [[Automatic behaviors]]
 
:* [[Upward eye-rolling]]
:*[[Automatic behaviors]]
:* [[Unconsciousness]]
:*[[Upward eye-rolling]]
:* [[Drolling]]
:*[[Unconsciousness]]
:* [[Cyanosis]]
:*[[Drolling]]
:* [[Tachycardia]]
:*[[Cyanosis]]
:* [[Hypertension]]
:*[[Tachycardia]]
:* [[Postictal drowsiness]]
:*[[Hypertension]]
:* [[Fever]]
:*[[Postictal drowsiness]]
:* [[Mydriasis]]
:*[[Fever]]
:* [[Nystagmus]]
:*[[Mydriasis]]
:* [[Urine]] and [[fecal incontinence]]
:*[[Nystagmus]]
:* [[Disorientation]] to person, place, time
:*[[Urine]] and [[fecal incontinence]]
:* [[Altered mental status]]
:*[[Disorientation]] to person, place, time
:*[[Altered mental status]]
 
*[[Physical examination]] associated with [[heart]] involvement in chronic [[epilepsy]] may include:
*[[Physical examination]] associated with [[heart]] involvement in chronic [[epilepsy]] may include:
:* [[Syncope]]
:* [[Leg edema]]
:* Elevated [[JVP]]
:* [[S3]],[[S4]]
:* [[Tachypnea]]
:* [[ Hypotension]]
:* [[ Pulsus alternans]]
:* [[Systolic murmur]] in [[heart apex]]
:* [[Irregular pulses]]


=== Laboratory Findings ===
:*[[Syncope]]
:*[[Leg edema]]
:*Elevated [[JVP]]
:*[[S3]],[[S4]]
:*[[Tachypnea]]
:*[[ Hypotension]]
:*[[ Pulsus alternans]]
:*[[Systolic murmur]] in [[heart apex]]
:*[[Irregular pulses]]
 
===Laboratory Findings===
Common laboratory findings related to [[epileptic heart]] may include:
Common laboratory findings related to [[epileptic heart]] may include:
*An elevated concentration of serum [[troponin I]] as the  marker of [[ myocardial injury]] in patients with [[generalized tonic-clonic seizure]].41.63.67
*An elevated concentration of serum [[troponin I]] as the  marker of [[ myocardial injury]] in patients with [[generalized tonic-clonic seizure]].41.63.67
* Increased [[CRP]], [[lipid]] profile due to induction of [[cytochrome P450]]  by antiepileptic drugs such as [[carbamazepine]], [[gabapentin]]
*Increased [[CRP]], [[lipid]] profile due to induction of [[cytochrome P450]]  by antiepileptic drugs such as [[carbamazepine]], [[gabapentin]]


===Electrocardiogram===
===Electrocardiogram===
An [[ECG]] may be helpful in the diagnosis of [[epileptic heart]]. Findings on an [[ECG]] suggestive of effects of [[seizure]] on the [[heart]] include:<ref name="M. RamadanEl-Shahat2013">{{cite journal|last1=M. Ramadan|first1=Mahmoud|last2=El-Shahat|first2=Nader|last3=A. Omar|first3=Ashraf|last4=Gomaa|first4=Mohamed|last5=Belal|first5=Tamer|last6=A. Sakr|first6=Sherif|last7=Abu-Hegazy|first7=Mohammad|last8=Hakim|first8=Hazem|last9=A. Selim|first9=Heba|last10=A. Omar|first10=Sabry|title=Interictal Electrocardiographic and Echocardiographic Changes in Patients With Generalized Tonic-Clonic Seizures|journal=International Heart Journal|volume=54|issue=3|year=2013|pages=171–175|issn=1349-2365|doi=10.1536/ihj.54.171}}</ref><ref name="LendeArends2019">{{cite journal|last1=Lende|first1=Marije|last2=Arends|first2=Johan B.|last3=Lamberts|first3=Robert J.|last4=Tan|first4=Hanno L.|last5=Lange|first5=Frederik J.|last6=Sander|first6=Josemir W.|last7=Aerts|first7=Arnaud J.|last8=Swart|first8=Henk P.|last9=Thijs|first9=Roland D.|title=The yield of long‐term electrocardiographic recordings in refractory focal epilepsy|journal=Epilepsia|volume=60|issue=11|year=2019|pages=2215–2223|issn=0013-9580|doi=10.1111/epi.16373}}</ref>
An [[ECG]] may be helpful in the diagnosis of [[epileptic heart]]. Findings on an [[ECG]] suggestive of effects of [[seizure]] on the [[heart]] include:<ref name="M. RamadanEl-Shahat2013">{{cite journal|last1=M. Ramadan|first1=Mahmoud|last2=El-Shahat|first2=Nader|last3=A. Omar|first3=Ashraf|last4=Gomaa|first4=Mohamed|last5=Belal|first5=Tamer|last6=A. Sakr|first6=Sherif|last7=Abu-Hegazy|first7=Mohammad|last8=Hakim|first8=Hazem|last9=A. Selim|first9=Heba|last10=A. Omar|first10=Sabry|title=Interictal Electrocardiographic and Echocardiographic Changes in Patients With Generalized Tonic-Clonic Seizures|journal=International Heart Journal|volume=54|issue=3|year=2013|pages=171–175|issn=1349-2365|doi=10.1536/ihj.54.171}}</ref><ref name="LendeArends2019">{{cite journal|last1=Lende|first1=Marije|last2=Arends|first2=Johan B.|last3=Lamberts|first3=Robert J.|last4=Tan|first4=Hanno L.|last5=Lange|first5=Frederik J.|last6=Sander|first6=Josemir W.|last7=Aerts|first7=Arnaud J.|last8=Swart|first8=Henk P.|last9=Thijs|first9=Roland D.|title=The yield of long‐term electrocardiographic recordings in refractory focal epilepsy|journal=Epilepsia|volume=60|issue=11|year=2019|pages=2215–2223|issn=0013-9580|doi=10.1111/epi.16373}}</ref>
*[[Bundle-branch block]]  
 
*[[Bundle-branch block]]
*[[ST-segment changes]] indicating  [[myocardial ischemia]] in 40% of [[seizures]]
*[[ST-segment changes]] indicating  [[myocardial ischemia]] in 40% of [[seizures]]
*[[T-wave]] inversion
*[[T-wave]] inversion
Line 212: Line 230:
*[[QT interval ]] prolongation
*[[QT interval ]] prolongation
*[[QT]] interval dispersion
*[[QT]] interval dispersion
* Increased [[T wave]] alternance in preictal and post ictal phases of [[generalized tonic-clonic seizure]] indicating [[repolarization]] abnormality
*Increased [[T wave]] alternance in preictal and post ictal phases of [[generalized tonic-clonic seizure]] indicating [[repolarization]] abnormality
* Decreased [[heart rate variability]] indicating  decreased [[vagus nerve]] activity  during [[seizure]]
*Decreased [[heart rate variability]] indicating  decreased [[vagus nerve]] activity  during [[seizure]]
* [[Sinus tachycardia]], [[heart rate]] >150/min indicating sympathetic discharge  
*[[Sinus tachycardia]], [[heart rate]] >150/min indicating sympathetic discharge
:* Common [[ECG]] markers associated [[sudden cardiac death]] include:
 
* [[Peri ictal]] [[QT]] prolongation
:*Common [[ECG]] markers associated [[sudden cardiac death]] include:
 
*[[Peri ictal]] [[QT]] prolongation
*Increased [[T waves alternance]]
*Increased [[T waves alternance]]
*Decreased [[heart rate variability]]<ref name="LotufoValiengo2012">{{cite journal|last1=Lotufo|first1=Paulo A.|last2=Valiengo|first2=Leandro|last3=Benseñor|first3=Isabela M.|last4=Brunoni|first4=Andre R.|title=A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs|journal=Epilepsia|volume=53|issue=2|year=2012|pages=272–282|issn=00139580|doi=10.1111/j.1528-1167.2011.03361.x}}</ref>
*Decreased [[heart rate variability]]<ref name="LotufoValiengo2012">{{cite journal|last1=Lotufo|first1=Paulo A.|last2=Valiengo|first2=Leandro|last3=Benseñor|first3=Isabela M.|last4=Brunoni|first4=Andre R.|title=A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs|journal=Epilepsia|volume=53|issue=2|year=2012|pages=272–282|issn=00139580|doi=10.1111/j.1528-1167.2011.03361.x}}</ref>
Line 229: Line 249:
*[[Post ictal]] [[atrial flutter]]
*[[Post ictal]] [[atrial flutter]]
*[[Post ictal]] [[ventricular fibrillation]]<ref name="EspinosaLee2009">{{cite journal|last1=Espinosa|first1=P. S.|last2=Lee|first2=J. W.|last3=Tedrow|first3=U. B.|last4=Bromfield|first4=E. B.|last5=Dworetzky|first5=B. A.|title=SUDDEN UNEXPECTED NEAR DEATH IN EPILEPSY: MALIGNANT ARRHYTHMIA FROM A PARTIAL SEIZURE|journal=Neurology|volume=72|issue=19|year=2009|pages=1702–1703|issn=0028-3878|doi=10.1212/WNL.0b013e3181a55f90}}</ref>
*[[Post ictal]] [[ventricular fibrillation]]<ref name="EspinosaLee2009">{{cite journal|last1=Espinosa|first1=P. S.|last2=Lee|first2=J. W.|last3=Tedrow|first3=U. B.|last4=Bromfield|first4=E. B.|last5=Dworetzky|first5=B. A.|title=SUDDEN UNEXPECTED NEAR DEATH IN EPILEPSY: MALIGNANT ARRHYTHMIA FROM A PARTIAL SEIZURE|journal=Neurology|volume=72|issue=19|year=2009|pages=1702–1703|issn=0028-3878|doi=10.1212/WNL.0b013e3181a55f90}}</ref>
::*Ictal [[asystole]], [[bradycardia]], [[AV block]] were self limiting.
::*Ictal [[asystole]], [[bradycardia]], [[AV block]] were self limiting.
::* Post ictal arrhythmia such as [[asystole]], [[AV block]], [[atrial fibrillation]], [[ventricular fibrillation]] were associated with near [[SUDEP]] or [[convulsion syncope]].
::*Post ictal arrhythmia such as [[asystole]], [[AV block]], [[atrial fibrillation]], [[ventricular fibrillation]] were associated with near [[SUDEP]] or [[convulsion syncope]].


===X-ray===
===X-ray===


A [[Chest-x-ray]] may be helpful in the diagnosis of [[heart involvement]] associated with [[chronic epilepsy]]. Findings on an [[CXR]] suggestive of [[heart]] involvement in [[epilepsy]] include:
A [[Chest-x-ray]] may be helpful in the diagnosis of [[heart involvement]] associated with [[chronic epilepsy]]. Findings on an [[CXR]] suggestive of [[heart]] involvement in [[epilepsy]] include:
:*[[Aortic arch calcification]]<ref name="IijimaHashimoto2010">{{cite journal|last1=Iijima|first1=Katsuya|last2=Hashimoto|first2=Hiroko|last3=Hashimoto|first3=Masayoshi|last4=Son|first4=Bo-Kyung|last5=Ota|first5=Hidetaka|last6=Ogawa|first6=Sumito|last7=Eto|first7=Masato|last8=Akishita|first8=Masahiro|last9=Ouchi|first9=Yasuyoshi|title=Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors|journal=Atherosclerosis|volume=210|issue=1|year=2010|pages=137–144|issn=00219150|doi=10.1016/j.atherosclerosis.2009.11.012}}</ref>
:*[[Aortic arch calcification]]<ref name="IijimaHashimoto2010">{{cite journal|last1=Iijima|first1=Katsuya|last2=Hashimoto|first2=Hiroko|last3=Hashimoto|first3=Masayoshi|last4=Son|first4=Bo-Kyung|last5=Ota|first5=Hidetaka|last6=Ogawa|first6=Sumito|last7=Eto|first7=Masato|last8=Akishita|first8=Masahiro|last9=Ouchi|first9=Yasuyoshi|title=Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors|journal=Atherosclerosis|volume=210|issue=1|year=2010|pages=137–144|issn=00219150|doi=10.1016/j.atherosclerosis.2009.11.012}}</ref>


Line 246: Line 268:


*Increased [[left ventricular filling pressures]]
*Increased [[left ventricular filling pressures]]
*Increased [[left atrial]] volume  
*Increased [[left atrial]] volume
*Increase [[left ventricular]] end systolic diameter
*Increase [[left ventricular]] end systolic diameter
*Increased [[left ventricular]] [[end systolic volume]] 64,65,66
*Increased [[left ventricular]] [[end systolic volume]] 64,65,66
Line 263: Line 285:
[[Cardiac magnetic resonance angiograpgy]] ([[MRA]]) may be helpful in the diagnosis of [[ischemic heart disease]] in chronic [[epilepsy]]. Findings on [[MRA]] suggestive of high-risk patients include:<ref name="YuanKerwin2004">{{cite journal|last1=Yuan|first1=Chun|last2=Kerwin|first2=William S.|title=MRI of atherosclerosis|journal=Journal of Magnetic Resonance Imaging|volume=19|issue=6|year=2004|pages=710–719|issn=1053-1807|doi=10.1002/jmri.20070}}</ref>
[[Cardiac magnetic resonance angiograpgy]] ([[MRA]]) may be helpful in the diagnosis of [[ischemic heart disease]] in chronic [[epilepsy]]. Findings on [[MRA]] suggestive of high-risk patients include:<ref name="YuanKerwin2004">{{cite journal|last1=Yuan|first1=Chun|last2=Kerwin|first2=William S.|title=MRI of atherosclerosis|journal=Journal of Magnetic Resonance Imaging|volume=19|issue=6|year=2004|pages=710–719|issn=1053-1807|doi=10.1002/jmri.20070}}</ref>


* Severe [[coronary artery]] stenosis(>70%)
*Severe [[coronary artery]] stenosis(>70%)
*Plaque with thick lipid-rich core and a thin [[fibrous cap]] and [[intraplaque inflammation]]
*Plaque with thick lipid-rich core and a thin [[fibrous cap]] and [[intraplaque inflammation]]


Line 274: Line 296:


[[Holter ECG]] 24-48 hours may be helpful in the diagnosis of the arrhythmia-related [[epileptic heart]]. Findings suggestive of the occurrence of [[ventricular fibrillation]]  include:<ref name="TakasugiGoto2016">{{cite journal|last1=Takasugi|first1=Nobuhiro|last2=Goto|first2=Hiroko|last3=Takasugi|first3=Mieko|last4=Verrier|first4=Richard L.|last5=Kuwahara|first5=Takashi|last6=Kubota|first6=Tomoki|last7=Toyoshi|first7=Hiroyuki|last8=Nakashima|first8=Takashi|last9=Kawasaki|first9=Masanori|last10=Nishigaki|first10=Kazuhiko|last11=Minatoguchi|first11=Shinya|title=Prevalence of Microvolt T-Wave Alternans in Patients With Long QT Syndrome and Its Association With Torsade de Pointes|journal=Circulation: Arrhythmia and Electrophysiology|volume=9|issue=2|year=2016|issn=1941-3149|doi=10.1161/CIRCEP.115.003206}}</ref>
[[Holter ECG]] 24-48 hours may be helpful in the diagnosis of the arrhythmia-related [[epileptic heart]]. Findings suggestive of the occurrence of [[ventricular fibrillation]]  include:<ref name="TakasugiGoto2016">{{cite journal|last1=Takasugi|first1=Nobuhiro|last2=Goto|first2=Hiroko|last3=Takasugi|first3=Mieko|last4=Verrier|first4=Richard L.|last5=Kuwahara|first5=Takashi|last6=Kubota|first6=Tomoki|last7=Toyoshi|first7=Hiroyuki|last8=Nakashima|first8=Takashi|last9=Kawasaki|first9=Masanori|last10=Nishigaki|first10=Kazuhiko|last11=Minatoguchi|first11=Shinya|title=Prevalence of Microvolt T-Wave Alternans in Patients With Long QT Syndrome and Its Association With Torsade de Pointes|journal=Circulation: Arrhythmia and Electrophysiology|volume=9|issue=2|year=2016|issn=1941-3149|doi=10.1161/CIRCEP.115.003206}}</ref>
:* Higher level of [[T waves]] alternance  
 
:* Decrease [[heart rate variability ]]
:*Higher level of [[T waves]] alternance
:* [[QT prolongation]]  
:*Decrease [[heart rate variability ]]
:*[[QT prolongation]]
 
*Other diagnostic studies for epileptic include [[ECG]] patches which are worn for 14 days with a higher chance for detection of [[tachyarrhythmia]] compared with Holter [[ECG]].
*Other diagnostic studies for epileptic include [[ECG]] patches which are worn for 14 days with a higher chance for detection of [[tachyarrhythmia]] compared with Holter [[ECG]].


Line 284: Line 308:
Ventricular late potentials recorded on signal averaged electrocardiograms (SAECG), which reflect ventricular depolarization and functional substrate for ventricular tachycardia, were found to correlate with epilepsy disease duration, refractory status, and greater seizure frequency [111]. Abnormal cardiac conduction distinguished patients with epilepsy who died unexpectedly [112
Ventricular late potentials recorded on signal averaged electrocardiograms (SAECG), which reflect ventricular depolarization and functional substrate for ventricular tachycardia, were found to correlate with epilepsy disease duration, refractory status, and greater seizure frequency [111]. Abnormal cardiac conduction distinguished patients with epilepsy who died unexpectedly [112


== Treatment ==
==Treatment==
=== Medical Therapy ===
===Medical Therapy===
   
   
*The mainstay of therapy for [[epileptic heart]] is [[autonomic modulation]] by increased [[parasympathetic activity]], decreased [[sympathetic activity]] which is effective for reducing the [[seizure]] episodes and increased [[cardiac electrical]] stability by the following:
*The mainstay of therapy for [[epileptic heart]] is [[autonomic modulation]] by increased [[parasympathetic activity]], decreased [[sympathetic activity]] which is effective for reducing the [[seizure]] episodes and increased [[cardiac electrical]] stability by the following:
:*Changing the [[arrhythmogenic]] [[antiepileptic drugs]] to other types
:*Changing the [[arrhythmogenic]] [[antiepileptic drugs]] to other types
:* [[vagus nerve stimulation]] therapy for reduction [[sympathetic activity]] which is a major risk factor for [[ventricular fibrillation]]<ref name="SchomerNearing2014">{{cite journal|last1=Schomer|first1=Andrew C.|last2=Nearing|first2=Bruce D.|last3=Schachter|first3=Steven C.|last4=Verrier|first4=Richard L.|title=Vagus nerve stimulation reduces cardiac electrical instability assessed by quantitative T-wave alternans analysis in patients with drug-resistant focal epilepsy|journal=Epilepsia|volume=55|issue=12|year=2014|pages=1996–2002|issn=00139580|doi=10.1111/epi.12855}}</ref>
:*[[vagus nerve stimulation]] therapy for reduction [[sympathetic activity]] which is a major risk factor for [[ventricular fibrillation]]<ref name="SchomerNearing2014">{{cite journal|last1=Schomer|first1=Andrew C.|last2=Nearing|first2=Bruce D.|last3=Schachter|first3=Steven C.|last4=Verrier|first4=Richard L.|title=Vagus nerve stimulation reduces cardiac electrical instability assessed by quantitative T-wave alternans analysis in patients with drug-resistant focal epilepsy|journal=Epilepsia|volume=55|issue=12|year=2014|pages=1996–2002|issn=00139580|doi=10.1111/epi.12855}}</ref>


=== Surgery ===
===Surgery===
* [[Left stellectomy]] can only be performed for patients with [[Long QT syndrome]] who are at risk of [[ventricular fibrillation]].
 
*[[Left stellectomy]] can only be performed for patients with [[Long QT syndrome]] who are at risk of [[ventricular fibrillation]].
   
   
=== Prevention ===
===Prevention===
*[[Primary prevention]] measures in [[epileptic heart]] include:  
 
*[[Primary prevention]] measures in [[epileptic heart]] include:
 
:*Screening risk factors of [[coronary artery disease]] in every patients diagnosed with [[epilepsy]] consisting [[obesity]],[[hypertension]], [[hyperlipidemia]],[[diabetes mellitus]],[[smoking]]
:*Screening risk factors of [[coronary artery disease]] in every patients diagnosed with [[epilepsy]] consisting [[obesity]],[[hypertension]], [[hyperlipidemia]],[[diabetes mellitus]],[[smoking]]
:*The role of [[ICD]] implantation for [[primary prevention]] of [[ventricular tachyarrhythmia]] in patients with chronic [[epilepsy]] is unclear.<ref name="SteckerReinier2013">{{cite journal|last1=Stecker|first1=Eric C.|last2=Reinier|first2=Kyndaron|last3=Uy-Evanado|first3=Audrey|last4=Teodorescu|first4=Carmen|last5=Chugh|first5=Harpriya|last6=Gunson|first6=Karen|last7=Jui|first7=Jonathan|last8=Chugh|first8=Sumeet S.|title=Relationship Between Seizure Episode and Sudden Cardiac Arrest in Patients With Epilepsy|journal=Circulation: Arrhythmia and Electrophysiology|volume=6|issue=5|year=2013|pages=912–916|issn=1941-3149|doi=10.1161/CIRCEP.113.000544}}</ref>
:*The role of [[ICD]] implantation for [[primary prevention]] of [[ventricular tachyarrhythmia]] in patients with chronic [[epilepsy]] is unclear.<ref name="SteckerReinier2013">{{cite journal|last1=Stecker|first1=Eric C.|last2=Reinier|first2=Kyndaron|last3=Uy-Evanado|first3=Audrey|last4=Teodorescu|first4=Carmen|last5=Chugh|first5=Harpriya|last6=Gunson|first6=Karen|last7=Jui|first7=Jonathan|last8=Chugh|first8=Sumeet S.|title=Relationship Between Seizure Episode and Sudden Cardiac Arrest in Patients With Epilepsy|journal=Circulation: Arrhythmia and Electrophysiology|volume=6|issue=5|year=2013|pages=912–916|issn=1941-3149|doi=10.1161/CIRCEP.113.000544}}</ref>
*The strategy for [[secondary prevention]] in [[chronic epileptic]] patients who are at risk of arrhythmia include:
*The strategy for [[secondary prevention]] in [[chronic epileptic]] patients who are at risk of arrhythmia include:
*Changing  [[arrhythmogenic]] drugs  that block [[sodium channel]] such as [[carbamazepine]], [[phenytoin]] to other types
*Changing  [[arrhythmogenic]] drugs  that block [[sodium channel]] such as [[carbamazepine]], [[phenytoin]] to other types
Line 305: Line 334:




:* 12 lead [[ECG]]
:*12 lead [[ECG]]
:*[[Holter ECG]] 24-48 hours
:*[[Holter ECG]] 24-48 hours
:*[[Wireless ECG patches]] (patient-friendly tool, worn for 14 days, increased chance for detection of arrhythmia compared  with [[Holter ECG]])
:*[[Wireless ECG patches]] (patient-friendly tool, worn for 14 days, increased chance for detection of arrhythmia compared  with [[Holter ECG]])

Revision as of 18:42, 27 January 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Sahar Memar Montazerin, M.D.[3]


Synonyms and keywords:

Overview

Chronic epileptic episodes and the subsequent catecholamine surges and hypoxic events may affect the heart and coronary vessels and result in the dysfunction of the heart. This condition is known as the "epileptic heart." This concept was first described by Dr. Richard L. Verrier and his colleagues in 2020.

Historical Perspective

  • Absence of cardiac activity during epileptic seizure, first described by Dr. A.E. Russell, an English physician, in 1906.[1]
  • The epileptic heart was first described by Drs. Verrier, Pang, Nearing, and Schachter, in 2020.[2]

Classification

  • There is no established system for the classification of the epileptic heart.

Pathophysiology

  • The exact mechanisms involved in the development of the epileptic heart are still being elucidated. However, the conceptual framework below provides helpful information on the development of heart disease in patients with epilepsy.[3]
 
 
 
 
 
 
 
 
 
Chronic epilepsy
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Repeated hypoxia and subsequent myocardial ischemia
 
Accelerated atherosclerosis
 
Myocardial stunning
 
Vacuolization of myocytes and fibrosis
 
Catecholamine-induced cardiotoxicity
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Epileptic Heart
❑ Cardiac electrical instability
❑ T wave alternans
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Epilepsy and Cardiac Arrhythmia

Cardiac arrhythmias have long been observed in patients with epilepsy. Three different mechanisms explain this association:[4]

Epilepsy and Structural Heart Disease

Three mechanisms have been suggested to explain the association between epilepsy and structural heart disease:[4]

Causes

Epileptic heart may be caused by the following:

Differentiating epileptic heart from other Diseases

Epileptic heart Sudden unexpected death in epilepsy SUDEP Convulsion syncope Epileptic seizure

Epidemiology and Demographics

  • The incidence of heart disease such as coronary artery disease, heart attack in patients with epilepsy is approximately 25600 per 100,000 individuals between 45-64 years old. This amount in patients without epilepsy is 11500 per 100,000 individuals between 45-64 years old..[19]
  • In 2018, the incidence of sudden cardiac death in epileptic patients was estimated to be 4400 cases per 100,000 individuals in the united states which was 4.5 fold of SUDEP cases.[25]
  • The incidence of heart disease in patients with epilepsy was 9% higher than patients without epilepsy.[19]


Age

Gender

  • Males are more commonly affected with epileptic heart than females

Race

  • There is no racial predilection for epileptic heart.

Risk Factors

Screening

Currently, there is no guideline statement that recommended routine cardiac evaluation of patients with epilepsy. However, a resting 12-lead EKG and/or ambulatory EKG patch recording may be useful in identifying the patients at risk of cardiac pathology and further follow the progression of their cardiac pathology.[2]

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

  • The diagnosis of the epileptic heart is made when the following diagnostic criteria are met:


History and Symptoms

Physical Examination

  • Physical examination associated with epilepsy include:

Laboratory Findings

Common laboratory findings related to epileptic heart may include:

Electrocardiogram

An ECG may be helpful in the diagnosis of epileptic heart. Findings on an ECG suggestive of effects of seizure on the heart include:[27][28]

X-ray

A Chest-x-ray may be helpful in the diagnosis of heart involvement associated with chronic epilepsy. Findings on an CXR suggestive of heart involvement in epilepsy include:

Echocardiography or Ultrasound

Echocardiography may be helpful in the diagnosis of epilectic heart. Findings on an echocardiography diagnostic of epileptic heart include: [27]

CT scan

Coronary CT angiography may be helpful in the diagnosis of ischemic heart disease in chronic epilepsy. Findings on coronary CTangiography suggestive of ischemic hear disease include:[33]

MRI

Cardiac magnetic resonance angiograpgy (MRA) may be helpful in the diagnosis of ischemic heart disease in chronic epilepsy. Findings on MRA suggestive of high-risk patients include:[34]

Other Imaging Findings

There are no other imaging findings associated with epileptic heart.

Other Diagnostic Studies

Holter ECG 24-48 hours may be helpful in the diagnosis of the arrhythmia-related epileptic heart. Findings suggestive of the occurrence of ventricular fibrillation include:[35]

  • Other diagnostic studies for epileptic include ECG patches which are worn for 14 days with a higher chance for detection of tachyarrhythmia compared with Holter ECG.



Ventricular late potentials recorded on signal averaged electrocardiograms (SAECG), which reflect ventricular depolarization and functional substrate for ventricular tachycardia, were found to correlate with epilepsy disease duration, refractory status, and greater seizure frequency [111]. Abnormal cardiac conduction distinguished patients with epilepsy who died unexpectedly [112

Treatment

Medical Therapy

Surgery

Prevention


References

  1. ↑ Russell, A.E. (1906). "CESSATION OF THE PULSE DURING THE ONSET OF EPILEPTIC FITS,". The Lancet. 168 (4325): 152–154. doi:10.1016/S0140-6736(01)30477-4. ISSN 0140-6736.
  2. ↑ 2.0 2.1 2.2 Verrier, Richard L.; Pang, Trudy D.; Nearing, Bruce D.; Schachter, Steven C. (2020). "The Epileptic Heart: Concept and clinical evidence". Epilepsy & Behavior. 105: 106946. doi:10.1016/j.yebeh.2020.106946. ISSN 1525-5050.
  3. ↑ Verrier, Richard L.; Schachter, Steven C. (2018). "Is heart disease in chronic epilepsy a consequence of seizures or a fellow traveler?". Epilepsy & Behavior. 86: 211–213. doi:10.1016/j.yebeh.2018.06.027. ISSN 1525-5050.
  4. ↑ 4.0 4.1 Shmuely, S.; van der Lende, M.; Lamberts, R.J.; Sander, J.W.; Thijs, R.D. (2017). "The heart of epilepsy: Current views and future concepts". Seizure. 44: 176–183. doi:10.1016/j.seizure.2016.10.001. ISSN 1059-1311.
  5. ↑ Hamed, Sherifa A. (2014). "Atherosclerosis in epilepsy: Its causes and implications". Epilepsy & Behavior. 41: 290–296. doi:10.1016/j.yebeh.2014.07.003. ISSN 1525-5050.
  6. ↑ Mintzer, Scott; Trinka, Eugen; Kraemer, Günter; Chervoneva, Inna; Werhahn, Konrad J. (2018). "Impact of carbamazepine, lamotrigine, and levetiracetam on vascular risk markers and lipid-lowering agents in the elderly". Epilepsia. 59 (10): 1899–1907. doi:10.1111/epi.14554. ISSN 0013-9580.
  7. ↑ Leestma, Jan E.; Walczak, Thaddeus; Hughes, John R.; Kalelkar, Mitra B.; Teas, Shaku S. (1989). "A prospective study on sudden unexpected death in epilepsy". Annals of Neurology. 26 (2): 195–203. doi:10.1002/ana.410260203. ISSN 0364-5134.
  8. ↑ Falconer, Bertil; Rajs, Jovan (1976). "Post-mortem findings of cardiac lesions in epileptics: A preliminary report". Forensic Science. 8: 63–71. doi:10.1016/0300-9432(76)90048-0. ISSN 0300-9432.
  9. ↑ Bardai, Abdennasser; Blom, Marieke T; van Noord, Charlotte; Verhamme, Katia M; Sturkenboom, Miriam C J M; Tan, Hanno L (2015). "Sudden cardiac death is associated both with epilepsy and with use of antiepileptic medications". Heart. 101 (1): 17–22. doi:10.1136/heartjnl-2014-305664. ISSN 1355-6037.
  10. ↑ Hookana, Eeva; Ansakorpi, Hanna; Kortelainen, Marja-Leena; Junttila, M. Juhani; Kaikkonen, Kari S; Perkiömäki, Juha; Huikuri, Heikki V (2016). "Antiepileptic medications and the risk for sudden cardiac death caused by an acute coronary event: a prospective case-control study". Annals of Medicine. 48 (1–2): 111–117. doi:10.3109/07853890.2016.1140225. ISSN 0785-3890.
  11. ↑ Granbichler, Claudia A.; Oberaigner, Willi; Kuchukhidze, Giorgi; Bauer, Gerhard; Ndayisaba, Jean-Pierre; Seppi, Klaus; Trinka, Eugen (2014). "Cause-specific mortality in adult epilepsy patients from Tyrol, Austria: hospital-based study". Journal of Neurology. 262 (1): 126–133. doi:10.1007/s00415-014-7536-z. ISSN 0340-5354.
  12. ↑ Baysal-Kirac, Leyla; Serbest, Nail Güven; Şahin, Erdi; Dede, Hava Özlem; Gürses, Candan; Gökyiğit, Ayşen; Bebek, Nerses; Bilge, Ahmet Kaya; Baykan, Betül (2017). "Analysis of heart rate variability and risk factors for SUDEP in patients with drug-resistant epilepsy". Epilepsy & Behavior. 71: 60–64. doi:10.1016/j.yebeh.2017.04.018. ISSN 1525-5050.
  13. ↑ DeGiorgio, Christopher M.; Miller, Patrick; Meymandi, Sheba; Chin, Alex; Epps, Jordan; Gordon, Steven; Gornbein, Jeffrey; Harper, Ronald M. (2010). "RMSSD, a measure of vagus-mediated heart rate variability, is associated with risk factors for SUDEP: The SUDEP-7 Inventory". Epilepsy & Behavior. 19 (1): 78–81. doi:10.1016/j.yebeh.2010.06.011. ISSN 1525-5050.
  14. ↑ Kiechl, Stefan; Bardai, Abdennasser; Lamberts, Robert J.; Blom, Marieke T.; Spanjaart, Anne M.; Berdowski, Jocelyn; van der Staal, Sebastiaan R.; Brouwer, Henk J.; Koster, Rudolph W.; Sander, Josemir W.; Thijs, Roland D.; Tan, Hanno L. (2012). "Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population". PLoS ONE. 7 (8): e42749. doi:10.1371/journal.pone.0042749. ISSN 1932-6203.
  15. ↑ Fineschi, V.; Silver, M.D.; Karch, S.B.; Parolini, M.; Turillazzi, E.; Pomara, C.; Baroldi, G. (2005). "Myocardial disarray: an architectural disorganization linked with adrenergic stress?". International Journal of Cardiology. 99 (2): 277–282. doi:10.1016/j.ijcard.2004.01.022. ISSN 0167-5273.
  16. ↑ Zhao, Haiting; Zhang, Honghai; Schoen, Frederick J.; Schachter, Steven C.; Feng, Hua-Jun (2019). "Repeated generalized seizures can produce calcified cardiac lesions in DBA/1 mice". Epilepsy & Behavior. 95: 169–174. doi:10.1016/j.yebeh.2019.04.010. ISSN 1525-5050.
  17. ↑ Chin, P. S.; Branch, K. R.; Becker, K. J. (2005). "Postictal neurogenic stunned myocardium". Neurology. 64 (11): 1977–1978. doi:10.1212/01.WNL.0000163858.77494.7A. ISSN 0028-3878.
  18. ↑ Naylor, Jillian; Churilov, Leonid; Johnstone, Benjamin; Guo, Ruibing; Xiong, Yunyun; Koome, Miriam; Chen, Ziyi; Thevathasan, Arthur; Chen, Ziyuan; Liu, Xinfeng; Kwan, Patrick; Campbell, Bruce C.V. (2018). "The Association Between Atrial Fibrillation and Poststroke Seizures is Influenced by Ethnicity and Environmental Factors". Journal of Stroke and Cerebrovascular Diseases. 27 (10): 2755–2760. doi:10.1016/j.jstrokecerebrovasdis.2018.05.044. ISSN 1052-3057.
  19. ↑ 19.0 19.1 19.2 Zack, Matthew; Luncheon, Cecily (2018). "Adults with an epilepsy history, notably those 45–64 years old or at the lowest income levels, more often report heart disease than adults without an epilepsy history". Epilepsy & Behavior. 86: 208–210. doi:10.1016/j.yebeh.2018.05.021. ISSN 1525-5050.
  20. ↑ Nashef, Lina; So, Elson L.; Ryvlin, Philippe; Tomson, Torbjörn (2012). "Unifying the definitions of sudden unexpected death in epilepsy". Epilepsia. 53 (2): 227–233. doi:10.1111/j.1528-1167.2011.03358.x. ISSN 0013-9580.
  21. ↑ Tomson, Torbjorn; Walczak, Ted; Sillanpaa, Matti; Sander, Josemir W. A. S. (2005). "Sudden Unexpected Death in Epilepsy: A Review of Incidence and Risk Factors". Epilepsia. 46 (s11): 54–61. doi:10.1111/j.1528-1167.2005.00411.x. ISSN 0013-9580.
  22. ↑ Surges, Rainer; Thijs, Roland D.; Tan, Hanno L.; Sander, Josemir W. (2009). "Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms". Nature Reviews Neurology. 5 (9): 492–504. doi:10.1038/nrneurol.2009.118. ISSN 1759-4758.
  23. ↑ Reeves, Andrew L.; Nollet, Kenneth E.; Klass, Donald W.; Sharbrough, Frank W.; So, Elson L. (1996). "The Ictal Bradycardia Syndrome". Epilepsia. 37 (10): 983–987. doi:10.1111/j.1528-1157.1996.tb00536.x. ISSN 0013-9580.
  24. ↑ Nashef, L; Walker, F; Allen, P; Sander, J W; Shorvon, S D; Fish, D R (1996). "Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy". Journal of Neurology, Neurosurgery & Psychiatry. 60 (3): 297–300. doi:10.1136/jnnp.60.3.297. ISSN 0022-3050.
  25. ↑ 25.0 25.1 Benjamin, Emelia J.; Virani, Salim S.; Callaway, Clifton W.; Chamberlain, Alanna M.; Chang, Alexander R.; Cheng, Susan; Chiuve, Stephanie E.; Cushman, Mary; Delling, Francesca N.; Deo, Rajat; de Ferranti, Sarah D.; Ferguson, Jane F.; Fornage, Myriam; Gillespie, Cathleen; Isasi, Carmen R.; Jiménez, Monik C.; Jordan, Lori Chaffin; Judd, Suzanne E.; Lackland, Daniel; Lichtman, Judith H.; Lisabeth, Lynda; Liu, Simin; Longenecker, Chris T.; Lutsey, Pamela L.; Mackey, Jason S.; Matchar, David B.; Matsushita, Kunihiro; Mussolino, Michael E.; Nasir, Khurram; O’Flaherty, Martin; Palaniappan, Latha P.; Pandey, Ambarish; Pandey, Dilip K.; Reeves, Mathew J.; Ritchey, Matthew D.; Rodriguez, Carlos J.; Roth, Gregory A.; Rosamond, Wayne D.; Sampson, Uchechukwu K.A.; Satou, Gary M.; Shah, Svati H.; Spartano, Nicole L.; Tirschwell, David L.; Tsao, Connie W.; Voeks, Jenifer H.; Willey, Joshua Z.; Wilkins, John T.; Wu, Jason HY.; Alger, Heather M.; Wong, Sally S.; Muntner, Paul (2018). "Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association". Circulation. 137 (12). doi:10.1161/CIR.0000000000000558. ISSN 0009-7322.
  26. ↑ Nass, Robert D.; Motloch, Lukas J.; Paar, Vera; Lichtenauer, Michael; Baumann, Jan; Zur, Berndt; Hoppe, Uta C.; Holdenrieder, Stefan; Elger, Christian E.; Surges, Rainer (2019). "Blood markers of cardiac stress after generalized convulsive seizures". Epilepsia. 60 (2): 201–210. doi:10.1111/epi.14637. ISSN 0013-9580.
  27. ↑ 27.0 27.1 M. Ramadan, Mahmoud; El-Shahat, Nader; A. Omar, Ashraf; Gomaa, Mohamed; Belal, Tamer; A. Sakr, Sherif; Abu-Hegazy, Mohammad; Hakim, Hazem; A. Selim, Heba; A. Omar, Sabry (2013). "Interictal Electrocardiographic and Echocardiographic Changes in Patients With Generalized Tonic-Clonic Seizures". International Heart Journal. 54 (3): 171–175. doi:10.1536/ihj.54.171. ISSN 1349-2365.
  28. ↑ Lende, Marije; Arends, Johan B.; Lamberts, Robert J.; Tan, Hanno L.; Lange, Frederik J.; Sander, Josemir W.; Aerts, Arnaud J.; Swart, Henk P.; Thijs, Roland D. (2019). "The yield of long‐term electrocardiographic recordings in refractory focal epilepsy". Epilepsia. 60 (11): 2215–2223. doi:10.1111/epi.16373. ISSN 0013-9580.
  29. ↑ Lotufo, Paulo A.; Valiengo, Leandro; Benseñor, Isabela M.; Brunoni, Andre R. (2012). "A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs". Epilepsia. 53 (2): 272–282. doi:10.1111/j.1528-1167.2011.03361.x. ISSN 0013-9580.
  30. ↑ van der Lende, Marije; Surges, Rainer; Sander, Josemir W; Thijs, Roland D (2015). "Cardiac arrhythmias during or after epileptic seizures". Journal of Neurology, Neurosurgery & Psychiatry: jnnp-2015–310559. doi:10.1136/jnnp-2015-310559. ISSN 0022-3050.
  31. ↑ Espinosa, P. S.; Lee, J. W.; Tedrow, U. B.; Bromfield, E. B.; Dworetzky, B. A. (2009). "SUDDEN UNEXPECTED NEAR DEATH IN EPILEPSY: MALIGNANT ARRHYTHMIA FROM A PARTIAL SEIZURE". Neurology. 72 (19): 1702–1703. doi:10.1212/WNL.0b013e3181a55f90. ISSN 0028-3878.
  32. ↑ Iijima, Katsuya; Hashimoto, Hiroko; Hashimoto, Masayoshi; Son, Bo-Kyung; Ota, Hidetaka; Ogawa, Sumito; Eto, Masato; Akishita, Masahiro; Ouchi, Yasuyoshi (2010). "Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors". Atherosclerosis. 210 (1): 137–144. doi:10.1016/j.atherosclerosis.2009.11.012. ISSN 0021-9150.
  33. ↑ Kolossváry, Márton; Szilveszter, Bálint; Merkely, Béla; Maurovich-Horvat, Pál (2017). "Plaque imaging with CT—a comprehensive review on coronary CT angiography based risk assessment". Cardiovascular Diagnosis and Therapy. 7 (5): 489–506. doi:10.21037/cdt.2016.11.06. ISSN 2223-3652.
  34. ↑ Yuan, Chun; Kerwin, William S. (2004). "MRI of atherosclerosis". Journal of Magnetic Resonance Imaging. 19 (6): 710–719. doi:10.1002/jmri.20070. ISSN 1053-1807.
  35. ↑ Takasugi, Nobuhiro; Goto, Hiroko; Takasugi, Mieko; Verrier, Richard L.; Kuwahara, Takashi; Kubota, Tomoki; Toyoshi, Hiroyuki; Nakashima, Takashi; Kawasaki, Masanori; Nishigaki, Kazuhiko; Minatoguchi, Shinya (2016). "Prevalence of Microvolt T-Wave Alternans in Patients With Long QT Syndrome and Its Association With Torsade de Pointes". Circulation: Arrhythmia and Electrophysiology. 9 (2). doi:10.1161/CIRCEP.115.003206. ISSN 1941-3149.
  36. ↑ 36.0 36.1 Schomer, Andrew C.; Nearing, Bruce D.; Schachter, Steven C.; Verrier, Richard L. (2014). "Vagus nerve stimulation reduces cardiac electrical instability assessed by quantitative T-wave alternans analysis in patients with drug-resistant focal epilepsy". Epilepsia. 55 (12): 1996–2002. doi:10.1111/epi.12855. ISSN 0013-9580.
  37. ↑ Stecker, Eric C.; Reinier, Kyndaron; Uy-Evanado, Audrey; Teodorescu, Carmen; Chugh, Harpriya; Gunson, Karen; Jui, Jonathan; Chugh, Sumeet S. (2013). "Relationship Between Seizure Episode and Sudden Cardiac Arrest in Patients With Epilepsy". Circulation: Arrhythmia and Electrophysiology. 6 (5): 912–916. doi:10.1161/CIRCEP.113.000544. ISSN 1941-3149.
  38. ↑ Pang, Trudy D.; Nearing, Bruce D.; Krishnamurthy, Kaarkuzhali Babu; Olin, Bryan; Schachter, Steven C.; Verrier, Richard L. (2019). "Cardiac electrical instability in newly diagnosed/chronic epilepsy tracked by Holter and ECG patch". Neurology. 93 (10): 450–458. doi:10.1212/WNL.0000000000008077. ISSN 0028-3878.

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