Coronavirus natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
Coronavirus [[infection]] can have a highly variable [[disease]] course. The [[infection]] can range from being [[Subclinical infection|subclinical]] to being an overt [[clinical]] condition. | Coronavirus [[infection]] can have a highly variable [[disease]] course. The [[infection]] can range from being [[Subclinical infection|subclinical]] to being an overt [[clinical]] condition. Coronavirus [[infection]] is most commonly [[Complication (medicine)|complicated]] by [[respiratory distress]] indicating [[mechanical ventilation]] and [[Intensive care unit|ICU]] care. The [[prognosis]] of the coronovirus [[infection]] is highly dependent on the type of the [[virus]] involved and the [[disease]] presentation. It has been noted that young [[Child|children]], [[Old age|elderly]], [[immunocompromised]], and individuals with [[Comorbidities|comorbid conditions]] are at the highest risk for worse [[prognosis]]. | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
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*The [[infection]] can range from being [[Subclinical infection|subclinical]] to being an overt [[clinical]] condition. | *The [[infection]] can range from being [[Subclinical infection|subclinical]] to being an overt [[clinical]] condition. | ||
==== SARS ==== | ===== SARS ===== | ||
* [[Severe acute respiratory syndrome|SARS]] begins with high [[fever]] (temperature greater than 100.4°F [> 38.0°C]).<ref>{{Cite web|url=https://www.cdc.gov/sars/about/fs-SARS.pdf|title=|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> | *[[Severe acute respiratory syndrome|SARS]] begins with high [[fever]] (temperature greater than 100.4°F [> 38.0°C]).<ref>{{Cite web|url=https://www.cdc.gov/sars/about/fs-SARS.pdf|title=|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> | ||
*The [[fever]] can later be accompanied by [[headache]], general feeling of [[discomfort]], and [[Diffuse pain|diffuse body pain]]. | *The [[fever]] can later be accompanied by [[headache]], general feeling of [[discomfort]], and [[Diffuse pain|diffuse body pain]]. | ||
*The condition worsens with time and [[patients]] can develop [[diarrhea]], [[dry cough]], and [[dyspnea]]. | *The condition worsens with time and [[patients]] can develop [[diarrhea]], [[dry cough]], and [[dyspnea]]. | ||
==== MERS ==== | ====== MERS ====== | ||
* [[Middle East respiratory syndrome coronavirus infection|MERS]] follows almost the same course as [[Severe acute respiratory syndrome|SARS]].<ref>{{Cite web|url=https://www.cdc.gov/coronavirus/mers/about/symptoms.html|title=|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> | *[[Middle East respiratory syndrome coronavirus infection|MERS]] follows almost the same course as [[Severe acute respiratory syndrome|SARS]].<ref>{{Cite web|url=https://www.cdc.gov/coronavirus/mers/about/symptoms.html|title=|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> | ||
* A significant proportion of [[Patient|patients]] were [[asymptomatic]] during the 2012 outbreak. | * A significant proportion of [[Patient|patients]] were [[asymptomatic]] during the 2012 outbreak. | ||
* Others presented with [[respiratory]] and/or [[gastrointestinal]] [[Symptom|symptoms]]. | * Others presented with [[respiratory]] and/or [[gastrointestinal]] [[Symptom|symptoms]]. | ||
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* Coronavirus [[infection]] is most commonly [[Complication (medicine)|complicated]] by [[respiratory distress]] indicating [[mechanical ventilation]] and [[Intensive care unit|ICU]] care. | * Coronavirus [[infection]] is most commonly [[Complication (medicine)|complicated]] by [[respiratory distress]] indicating [[mechanical ventilation]] and [[Intensive care unit|ICU]] care. | ||
* Other complications include: | * Other complications include: | ||
** | **[[Pneumonia]]<ref>{{Cite web|url=https://www.cdc.gov/coronavirus/mers/about/symptoms.html|title=|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> | ||
**[[Kidney failure]] | |||
=== Prognosis === | |||
* The [[prognosis]] of the coronovirus [[infection]] is highly dependent on the type of the [[virus]] involved and the [[disease]] presentation. | |||
* It has been noted that young [[Child|children]], [[Old age|elderly]], [[immunocompromised]], and individuals with [[Comorbidities|comorbid conditions]] are at the highest risk for worse [[prognosis]]. | |||
==References== | ==References== |
Revision as of 22:15, 31 January 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]
Overview
Coronavirus infection can have a highly variable disease course. The infection can range from being subclinical to being an overt clinical condition. Coronavirus infection is most commonly complicated by respiratory distress indicating mechanical ventilation and ICU care. The prognosis of the coronovirus infection is highly dependent on the type of the virus involved and the disease presentation. It has been noted that young children, elderly, immunocompromised, and individuals with comorbid conditions are at the highest risk for worse prognosis.
Natural History, Complications, and Prognosis
Natural History
- Coronavirus infection can have a highly variable disease course.
- The infection can range from being subclinical to being an overt clinical condition.
SARS
- SARS begins with high fever (temperature greater than 100.4°F [> 38.0°C]).[1]
- The fever can later be accompanied by headache, general feeling of discomfort, and diffuse body pain.
- The condition worsens with time and patients can develop diarrhea, dry cough, and dyspnea.
MERS
- MERS follows almost the same course as SARS.[2]
- A significant proportion of patients were asymptomatic during the 2012 outbreak.
- Others presented with respiratory and/or gastrointestinal symptoms.
2019-nCoV
- 2019-nCoV infection has been following the same pathway of the infamous coronavirus infections (SARS and MERS).
- The disease course can be insignificant in part due to the lack of symptoms.[3]
- When present, the initial symptoms can include fever, cough, and shortness of breath.
- Patients presenting with worsening symptoms are requiring mechanical ventilation and ICU care.
Complications
- Coronavirus infection is most commonly complicated by respiratory distress indicating mechanical ventilation and ICU care.
- Other complications include:
Prognosis
- The prognosis of the coronovirus infection is highly dependent on the type of the virus involved and the disease presentation.
- It has been noted that young children, elderly, immunocompromised, and individuals with comorbid conditions are at the highest risk for worse prognosis.
References
- ↑ (PDF) https://www.cdc.gov/sars/about/fs-SARS.pdf. Missing or empty
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(help) - ↑ https://www.cdc.gov/coronavirus/mers/about/symptoms.html. Missing or empty
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(help) - ↑ https://www.cdc.gov/coronavirus/2019-ncov/about/symptoms.html. Missing or empty
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(help) - ↑ https://www.cdc.gov/coronavirus/mers/about/symptoms.html. Missing or empty
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(help)