Diffuse pain

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Aches; chronic pain; musculoskeletal pain



Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Statins
Ear Nose Throat No underlying causes
Endocrine Hypothyroidism, Hyperthyroidism, Hyperparathyroidism, Adrenal insufficiency
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic Eosinophilia-myalgia syndrome
Iatrogenic No underlying causes
Infectious Disease Viral infection, Spirochetal infection, Bacterial infection
Musculoskeletal/Orthopedic Paget’s disease, Osteomalacia, Myositis, Myofascial pain syndrome, Muscle soreness from overuse, Chronic fatigue syndrome
Neurologic Entrapment neuropathy, Neuropathies, Multiple Sclerosis
Nutritional/Metabolic Scurvy , Metabolic myopathy
Obstetric/Gynecologic No underlying causes
Oncologic Paraneoplastic syndrome
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric Psycogenic rheumatism, Mood disorder, Depressed affect
Pulmonary No underlying causes
Renal/Electrolyte Hypophosphatemia
Rheumatology/Immunology/Allergy Vasculitis, Systemic lupus erythematosus, Spondyloarthropathy, Sjogren syndrome, Rheumatoid Arthritis, Reiter's Syndrome, Polymyalgia rheumatica, Fibromyalgia, Dermatomyositis, Dermatomyositis, Chronic fatigue syndrome , Bilateral soft tissue rheumatism, Postviral arthralgia, Ankylosing Spondylitis
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Overuse Syndromes, Hypermobility

Causes in Alphabetical Order


  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

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