Celiac disease risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]
Overview
Positive family history and presence of autoimmune diseases are the most potent risk factors for celiac disease.
Risk Factors
The most potent risk factors for development of celiac disease is positive family history. It can increase the prevalence of celiac disease up to 20% especially in first degree relatives.[1] Other important risk factor is presence of autoimmune diseases which include:[2]
- Type 1 diabetes mellitus
- Inflammatory luminal gastrointestinal disorders
- Down syndrome
- Turner syndrome
- IgA deficiency
- IgA nephropathy
References
- ↑ Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, Elitsur Y, Green PH, Guandalini S, Hill ID, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman SS, Murray JA, Horvath K (2003). "Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study". Arch. Intern. Med. 163 (3): 286–92. PMID 12578508.
- ↑ Murray JA (2005). "Celiac disease in patients with an affected member, type 1 diabetes, iron-deficiency, or osteoporosis?". Gastroenterology. 128 (4 Suppl 1): S52–6. PMID 15825127.