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'''Chemokine (C-C motif) ligand 16''' ('''CCL16''') is a small [[cytokine]] belonging to the CC [[chemokine]] family that is known under several [[pseudonym]]s, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the [[liver]], [[thymus]], and [[spleen]] and is chemoattractive for [[monocyte]]s and [[lymphocyte]]s.<ref name= | '''Chemokine (C-C motif) ligand 16''' ('''CCL16''') is a small [[cytokine]] belonging to the CC [[chemokine]] family that is known under several [[pseudonym]]s, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the [[liver]], [[thymus]], and [[spleen]] and is chemoattractive for [[monocyte]]s and [[lymphocyte]]s.<ref name="Youn_1998">{{cite journal | vauthors = Youn BS, Zhang S, Broxmeyer HE, Antol K, Fraser MJ, Hangoc G, Kwon BS | title = Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 2 | pages = 217–22 | date = June 1998 | pmid = 9642106 | doi = 10.1006/bbrc.1998.8762 }}</ref> Cellular expression of CCL16 can be strongly induced in monocytes by [[Interleukin 10|IL-10]], [[interferon#type II IFN|IFN-γ]] and bacterial [[lipopolysaccharide]]. Its [[gene]] is located on [[chromosome 17]], in humans, among a cluster of other CC chemokines.<ref name="Nomiyama_1991">{{cite journal | vauthors = Nomiyama H, Fukuda S, Iio M, Tanase S, Miura R, Yoshie O | title = Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES | journal = Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research | volume = 19 | issue = 3 | pages = 227–34 | date = March 1999 | pmid = 10213461 | doi = 10.1089/107999099314153 }}</ref> CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as [[CC chemokine receptors#CCR1|CCR1]], [[CC chemokine receptors#CCR2|CCR2]], [[CC chemokine receptors#CCR5|CCR5]] and [[CC chemokine receptors#CCR8|CCR8]].<ref name="Nomiyama_2001">{{cite journal | vauthors = Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, Nishiura H, Matsuno K, Takamori H, Tabira Y, Yamamoto T, Miura R, Yoshie O | title = Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes | journal = [[International Immunology]] | volume = 13 | issue = 8 | pages = 1021–9 | date = August 2001 | pmid = 11470772 | doi = }}</ref><ref Name="Howard_2000">{{cite journal | vauthors = Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ | title = LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8 | journal = Blood | volume = 96 | issue = 3 | pages = 840–5 | date = August 2000 | pmid = 10910894 | doi = }}</ref> | ||
C-C motif chemokine ligand 16 has been found in high levels in the blood plasma of humans.<ref name="Nakayama_2004">{{cite journal | vauthors = Nakayama T, Kato Y, Hieshima K, Nagakubo D, Kunori Y, Fujisawa T, Yoshie O | title = Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor | journal = Journal of Immunology | volume = 173 | issue = 3 | pages = 2078–83 | date = August 2004 | pmid = 15265943 | doi = 10.4049/jimmunol.173.3.2078 }}</ref> | |||
CCL16 may be useful for trafficking eosinophils. This ligand has been found to have a functional affinity for H4 receptors that are expressed by eosinophils and mast cells.<ref name="Nakayama_2004"/> | |||
This chemokine has been shown to suppress rapid proliferation of myeloid progenitor cells.<ref name="entrez">{{cite web | title = CCL16 C-C Motif Chemokine Ligand 16 [Homo Sapiens (Human)] Gene | work = National Center for Biotechnology Information, U.S. National Library of Medicine | url = https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=6360 }}</ref> | |||
{{clear}} | |||
==References== | ==References== | ||
{{Reflist}} | {{Reflist|32em}} | ||
{{Chemokines}} | {{Chemokines}} | ||
Latest revision as of 05:14, 15 June 2018
| chemokine (C-C motif) ligand 16 | |
|---|---|
| Identifiers | |
| Symbol | CCL16 |
| Alt. symbols | SCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1 |
| Entrez | 6360 |
| HUGO | 10614 |
| OMIM | 601394 |
| RefSeq | NM_004590 |
| UniProt | O15467 |
| Other data | |
| Locus | Chr. 17 q11.2 |
Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the liver, thymus, and spleen and is chemoattractive for monocytes and lymphocytes.[1] Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ and bacterial lipopolysaccharide. Its gene is located on chromosome 17, in humans, among a cluster of other CC chemokines.[2] CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8.[3][4]
C-C motif chemokine ligand 16 has been found in high levels in the blood plasma of humans.[5] CCL16 may be useful for trafficking eosinophils. This ligand has been found to have a functional affinity for H4 receptors that are expressed by eosinophils and mast cells.[5] This chemokine has been shown to suppress rapid proliferation of myeloid progenitor cells.[6]
References
- ↑ Youn BS, Zhang S, Broxmeyer HE, Antol K, Fraser MJ, Hangoc G, Kwon BS (June 1998). "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity". Biochemical and Biophysical Research Communications. 247 (2): 217–22. doi:10.1006/bbrc.1998.8762. PMID 9642106.
- ↑ Nomiyama H, Fukuda S, Iio M, Tanase S, Miura R, Yoshie O (March 1999). "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES". Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. 19 (3): 227–34. doi:10.1089/107999099314153. PMID 10213461.
- ↑ Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, Nishiura H, Matsuno K, Takamori H, Tabira Y, Yamamoto T, Miura R, Yoshie O (August 2001). "Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes". International Immunology. 13 (8): 1021–9. PMID 11470772.
- ↑ Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ (August 2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8". Blood. 96 (3): 840–5. PMID 10910894.
- ↑ 5.0 5.1 Nakayama T, Kato Y, Hieshima K, Nagakubo D, Kunori Y, Fujisawa T, Yoshie O (August 2004). "Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor". Journal of Immunology. 173 (3): 2078–83. doi:10.4049/jimmunol.173.3.2078. PMID 15265943.
- ↑ "CCL16 C-C Motif Chemokine Ligand 16 [Homo Sapiens (Human)] Gene". National Center for Biotechnology Information, U.S. National Library of Medicine.
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