Barrett's esophagus overview: Difference between revisions
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==Overview== | ==Overview== | ||
Barrett's esophagus refers to an [[abnormal]] change ([[metaplasia]]) in the [[cells]] of the lower end of the [[esophagus]] [[thought]] to be caused by damage from [[chronic]] [[acid]] exposure, or [[reflux esophagitis]]. It is a condition in which any extent of metaplastic [[columnar epithelium]] replaces the [[normal]] [[stratified squamous epithelium]] in the [[distal]] [[esophagus]]. [[Intestinal]] [[metaplasia]] is required for the [[diagnosis]] of Barrett's esophagus. | |||
==Historical Perspective== | ==Historical Perspective== | ||
Barrett's esophagus was first discovered by Dr. Norman Barrett, a Australian-born British surgeon at St Thomas' Hospital, in 1957. | |||
==Classification== | ==Classification== | ||
Barrett's esophagus may be classified according to the distance between Z line and GEJ (Gastroesophgeal Junction) into two subtypes which are long segment barrett's esophagus and short segment barrett's esophagus. | |||
==Pathophysiology== | ==Pathophysiology== | ||
Barrett's esophagus is marked by the presence of [[columnar epithelium]] in the lower [[esophagus]], replacing the normal squamous cell epithelium; an example of [[metaplasia]]. The [[columnar epithelium]] is better able to withstand the erosive action of the [[gastric]] [[secretions]]; however, this [[metaplasia]] confers an increased [[cancer]] risk of the [[adenocarcinoma]] type. | |||
==Causes== | ==Causes== | ||
Barrett's esophagus is commonly caused by [[Gastroesophageal reflux disease]]. | |||
==Differentiating | ==Differentiating Barrett's Esophagus from Other Diseases== | ||
Barrett's esophagus must be differentiated from [[esophagitis]], [[peptic ulcer disease]], [[esophageal carcinoma]] and [[esophageal]] motor [[disorders]]. | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Barrett's esophagus can be seen in younger [[patients]], but is most commonly diagnosed in [[patients]] around 55 years of age. The [[prevalence]] of Barrett's esophagus is approximately 2000 per 100,000 individuals worldwide. | |||
==Risk Factors== | ==Risk Factors== | ||
The most potent [[risk factor]] in the [[development]] of | The most potent [[risk factor]] in the [[development]] of Barrett's esophagus is [[chronic]] [[GERD]]. Other [[risk factors]] include age (>older than 50 years), sex (male), [[race]] (caucasian), [[hiatal hernia]], elevated [[body mass index]] and intra-abdominal distribution of body fat. | ||
==Screening== | ==Screening== | ||
Barrett's esophagus is a major [[risk factor]] for development of [[Esophageal cancer pathophysiology|esophageal adenocarcinoma]]. After diagnosis, regular surveillance is needed based on the grade of [[dysplasia]]. Weak recommendation, moderate-quality [[evidence]]: [[screening]] in patients with multiple [[risk factors]] for [[Esophageal cancer pathophysiology|esophageal adenocarcinoma]]: age > 50 years old, male, white, chronic [[GERD]], [[hiatal hernia]], elevated [[BMI]] (body mass index), and intra-abdominal distribution of body fat. Strong recommendation, low-quality evidence against screening general population with [[GERD]] and no [[risk factors]]. | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
Common [[complications]] of | Common [[complications]] of Barrett's esophagus include [[esophageal carcinoma]], [[esophageal stricture]] and [[esophageal]] [[ulcers]]. | ||
==Diagnosis== | ==Diagnosis== | ||
===Diagnostic Criteria=== | ===Diagnostic Criteria=== | ||
The [[diagnosis]] of | The [[diagnosis]] of Barrett's esophagus is made on [[endoscopy]], when at least 2 of the following [[diagnostic]] [[criteria]] are met which include presence of [[columnar epithelium]] in the [[distal]] [[esophagus]] and the presence of [[intestinal]] [[metaplasia]] in the [[columnar epithelium]] lining the distal [[esophagus]]. | ||
===History and Symptoms=== | ===History and Symptoms=== | ||
Common [[symptoms]] of | Common [[symptoms]] of Barrett's esophagus include [[heartburn]], [[regurgitation]], and [[dysphagia]]. A positive history of [[nausea]], [[vomiting]], and [[regurgitation]] is suggestive of Barrett's esophagus. Other [[symptoms]] of Barrett's esophagus include [[chest pain]], [[cough]], and [[odynophagia]]. | ||
===Physical Examination=== | ===Physical Examination=== | ||
Patients with | Patients with Barrett's esophagus usually appear [[Ill feeling|ill]] due to the [[pain]]. Common [[physical examination]] include [[hoarseness]] of [[voice]], [[laryngitis]], [[otitis media]], and [[Wheeze|lung wheezes]]. | ||
===Laboratory Findings=== | ===Laboratory Findings=== | ||
[[Laboratory]] findings consistent with [[diagnosis]] of | [[Laboratory]] findings consistent with [[diagnosis]] of Barrett's esophagus is the presence of [[acidic]] [[reflux]] in [[Esophagus|the esophagus]] through the ambulatory [[reflux]] monitoring. | ||
===Electrocardiogram=== | ===Electrocardiogram=== | ||
There are no [[EKG]] findings associated with | There are no [[EKG]] findings associated with Barrett's esophagus. However, [[EKG]] can be performed to exclude the [[cardiac]] causes of [[chest pain]] that can be presented in cases of atypical [[GERD]]. | ||
===X-ray=== | ===X-ray=== | ||
There are no x-ray findings associated with | There are no x-ray findings associated with Barrett's esophagus. | ||
===Ultrasound=== | ===Ultrasound=== | ||
There are no [[echocardiography]] or [[ultrasound]] findings associated with | There are no [[echocardiography]] or [[ultrasound]] findings associated with Barrett's esophagus. | ||
===CT scan=== | ===CT scan=== | ||
There are no [[CT scan]] findings associated with | There are no [[CT scan]] findings associated with Barrett's esophagus. | ||
===MRI=== | ===MRI=== | ||
There are no [[MRI]] findings associated with | There are no [[MRI]] findings associated with Barrett's esophagus. | ||
===Other Imaging Findings=== | ===Other Imaging Findings=== | ||
Unsedated [[esophagoscopy]] and [[capsule]] [[esophagoscopy]] may be helpful in the [[diagnosis]] of | Unsedated [[esophagoscopy]] and [[capsule]] [[esophagoscopy]] may be helpful in the [[diagnosis]] of Barrett's esophagus. | ||
===Other Diagnostic Studies=== | ===Other Diagnostic Studies=== | ||
There are no other [[diagnostic]] studies associated with | There are no other [[diagnostic]] studies associated with Barrett's esophagus. | ||
==Treatment== | ==Treatment== | ||
===Medical Therapy=== | ===Medical Therapy=== | ||
According to the American College of Gastroenterology, the [[patients]] with | According to the American College of Gastroenterology, the [[patients]] with Barrett's esophagus are treated with both lifestyle changes and [[medications]]. The lifestyle changes includes avoiding [[dietary]] [[fat]], [[chocolate]], [[caffeine]], [[peppermint]], [[alcohol]], [[tobacco]], avoiding lying down after meals, losing [[weight]], sleeping with the [[head]] of the bed elevated and taking all [[medications]] with plenty of [[water]]. The [[medications]] used to treat [[Barrett's esophagus]] are H2-receptor antagonists, [[Proton pump inhibitor]] and Photosensitizers. | ||
===Surgery=== | ===Surgery=== | ||
According to the American College of Gastroenterology, there are various [[surgical]] methods used for the treatment of | According to the American College of Gastroenterology, there are various [[surgical]] methods used for the treatment of Barrett's esophagus which includes (1) antireflux [[surgery]] considered in those with incomplete control of [[reflux]] on optimized [[medical]] [[therapy]], (2)[[esophagectomy]] in cases of [[Endoscopic]] [[adenocarcinoma]] (EAC) with [[invasion]] into the [[submucosa]] and (3) [[Nissen fundoplication]] used in the patient with [[GERD]] [[symptoms]]. | ||
===Primary Prevention=== | ===Primary Prevention=== | ||
Effective measures for the primary [[prevention]] of | Effective measures for the primary [[prevention]] of Barrett's esophagus include [[lifestyle]] modifications and [[medical]] [[therapy]] for [[GERD]]. Lifestyle modification include [[weight loss]], head of bed [[elevation]], avoidance of nighttime meals, and elimination of trigger foods such as [[chocolate]], [[caffeine]] and [[alcohol]]. [[Medical]] [[therapy]] include the use of [[proton pump]] inhibitors. | ||
===Secondary Prevention=== | ===Secondary Prevention=== | ||
Effective measures for the [[secondary]] [[prevention]] of | Effective measures for the [[secondary]] [[prevention]] of Barrett's esophagus include primary [[prevention]] along with [[endoscopic]] surveillance every 3-5 years for no [[dysplasia]], 6-12 months for low-grade [[dysplasia]], and every 3 months for high-grade [[dysplasia]] in the absence of eradication [[therapy]]. | ||
==References== | ==References== | ||
Latest revision as of 19:59, 6 February 2018
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Barrett's Esophagus Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Barrett's esophagus overview On the Web |
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American Roentgen Ray Society Images of Barrett's esophagus overview |
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Risk calculators and risk factors for Barrett's esophagus overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amresh Kumar MD [2], Hamid Qazi, MD, BSc [3]
| https://www.youtube.com/watch?v=m6FIrOAe2TY&t%7C350}} |
Overview
Barrett's esophagus refers to an abnormal change (metaplasia) in the cells of the lower end of the esophagus thought to be caused by damage from chronic acid exposure, or reflux esophagitis. It is a condition in which any extent of metaplastic columnar epithelium replaces the normal stratified squamous epithelium in the distal esophagus. Intestinal metaplasia is required for the diagnosis of Barrett's esophagus.
Historical Perspective
Barrett's esophagus was first discovered by Dr. Norman Barrett, a Australian-born British surgeon at St Thomas' Hospital, in 1957.
Classification
Barrett's esophagus may be classified according to the distance between Z line and GEJ (Gastroesophgeal Junction) into two subtypes which are long segment barrett's esophagus and short segment barrett's esophagus.
Pathophysiology
Barrett's esophagus is marked by the presence of columnar epithelium in the lower esophagus, replacing the normal squamous cell epithelium; an example of metaplasia. The columnar epithelium is better able to withstand the erosive action of the gastric secretions; however, this metaplasia confers an increased cancer risk of the adenocarcinoma type.
Causes
Barrett's esophagus is commonly caused by Gastroesophageal reflux disease.
Differentiating Barrett's Esophagus from Other Diseases
Barrett's esophagus must be differentiated from esophagitis, peptic ulcer disease, esophageal carcinoma and esophageal motor disorders.
Epidemiology and Demographics
Barrett's esophagus can be seen in younger patients, but is most commonly diagnosed in patients around 55 years of age. The prevalence of Barrett's esophagus is approximately 2000 per 100,000 individuals worldwide.
Risk Factors
The most potent risk factor in the development of Barrett's esophagus is chronic GERD. Other risk factors include age (>older than 50 years), sex (male), race (caucasian), hiatal hernia, elevated body mass index and intra-abdominal distribution of body fat.
Screening
Barrett's esophagus is a major risk factor for development of esophageal adenocarcinoma. After diagnosis, regular surveillance is needed based on the grade of dysplasia. Weak recommendation, moderate-quality evidence: screening in patients with multiple risk factors for esophageal adenocarcinoma: age > 50 years old, male, white, chronic GERD, hiatal hernia, elevated BMI (body mass index), and intra-abdominal distribution of body fat. Strong recommendation, low-quality evidence against screening general population with GERD and no risk factors.
Natural History, Complications, and Prognosis
Common complications of Barrett's esophagus include esophageal carcinoma, esophageal stricture and esophageal ulcers.
Diagnosis
Diagnostic Criteria
The diagnosis of Barrett's esophagus is made on endoscopy, when at least 2 of the following diagnostic criteria are met which include presence of columnar epithelium in the distal esophagus and the presence of intestinal metaplasia in the columnar epithelium lining the distal esophagus.
History and Symptoms
Common symptoms of Barrett's esophagus include heartburn, regurgitation, and dysphagia. A positive history of nausea, vomiting, and regurgitation is suggestive of Barrett's esophagus. Other symptoms of Barrett's esophagus include chest pain, cough, and odynophagia.
Physical Examination
Patients with Barrett's esophagus usually appear ill due to the pain. Common physical examination include hoarseness of voice, laryngitis, otitis media, and lung wheezes.
Laboratory Findings
Laboratory findings consistent with diagnosis of Barrett's esophagus is the presence of acidic reflux in the esophagus through the ambulatory reflux monitoring.
Electrocardiogram
There are no EKG findings associated with Barrett's esophagus. However, EKG can be performed to exclude the cardiac causes of chest pain that can be presented in cases of atypical GERD.
X-ray
There are no x-ray findings associated with Barrett's esophagus.
Ultrasound
There are no echocardiography or ultrasound findings associated with Barrett's esophagus.
CT scan
There are no CT scan findings associated with Barrett's esophagus.
MRI
There are no MRI findings associated with Barrett's esophagus.
Other Imaging Findings
Unsedated esophagoscopy and capsule esophagoscopy may be helpful in the diagnosis of Barrett's esophagus.
Other Diagnostic Studies
There are no other diagnostic studies associated with Barrett's esophagus.
Treatment
Medical Therapy
According to the American College of Gastroenterology, the patients with Barrett's esophagus are treated with both lifestyle changes and medications. The lifestyle changes includes avoiding dietary fat, chocolate, caffeine, peppermint, alcohol, tobacco, avoiding lying down after meals, losing weight, sleeping with the head of the bed elevated and taking all medications with plenty of water. The medications used to treat Barrett's esophagus are H2-receptor antagonists, Proton pump inhibitor and Photosensitizers.
Surgery
According to the American College of Gastroenterology, there are various surgical methods used for the treatment of Barrett's esophagus which includes (1) antireflux surgery considered in those with incomplete control of reflux on optimized medical therapy, (2)esophagectomy in cases of Endoscopic adenocarcinoma (EAC) with invasion into the submucosa and (3) Nissen fundoplication used in the patient with GERD symptoms.
Primary Prevention
Effective measures for the primary prevention of Barrett's esophagus include lifestyle modifications and medical therapy for GERD. Lifestyle modification include weight loss, head of bed elevation, avoidance of nighttime meals, and elimination of trigger foods such as chocolate, caffeine and alcohol. Medical therapy include the use of proton pump inhibitors.
Secondary Prevention
Effective measures for the secondary prevention of Barrett's esophagus include primary prevention along with endoscopic surveillance every 3-5 years for no dysplasia, 6-12 months for low-grade dysplasia, and every 3 months for high-grade dysplasia in the absence of eradication therapy.