Autoimmune hepatitis risk factors: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Autoimmune hepatitis}} | {{Autoimmune hepatitis}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}}{{MKK}} | ||
==Overview== | ==Overview== | ||
Common risk factors in the development of | Common risk factors in the development of [[autoimmune hepatitis]] include [[female]] gender, [[Genetic predisposition]] associated with [[HLA-DR3]] and [[HLA-DR4]], and history of other [[autoimmune hepatitis|autoimmune]] hepatitis eg [[thyroiditis]], [[type 1 diabetes]], [[ulcerative colitis]], [[celiac disease]], and [[rheumatoid arthritis]]. | ||
==Risk Factors== | ==Risk Factors== | ||
===Common Risk Factors=== | ===Common Risk Factors=== | ||
Common risk factors in the development of | Common risk factors in the development of [[autoimmune hepatitis]] include: | ||
*Females: | *[[Females]]: | ||
**Autoimmune hepatitis is more common in young females | **Autoimmune hepatitis is more common in young females. | ||
*Genetic predisposition:<ref name="pmid15288484">{{cite journal |vauthors=Donaldson PT |title=Genetics of autoimmune and viral liver diseases; understanding the issues |journal=J. Hepatol. |volume=41 |issue=2 |pages=327–32 |year=2004 |pmid=15288484 |doi=10.1016/j.jhep.2004.06.001 |url=}}</ref> | *[[Genetic predisposition]]:<ref name="pmid15288484">{{cite journal |vauthors=Donaldson PT |title=Genetics of autoimmune and viral liver diseases; understanding the issues |journal=J. Hepatol. |volume=41 |issue=2 |pages=327–32 |year=2004 |pmid=15288484 |doi=10.1016/j.jhep.2004.06.001 |url=}}</ref> | ||
**Autoimmune hepatitis type 1 has the association with HLA-DR3 and HLA-DR4 | **Autoimmune hepatitis type 1 has the association with [[HLA]]-DR3 and [[HLA]]-DR4. | ||
**Type 2 AIH has an association with the HLA-DQB1 and HLA-DRB1 alleles | **Type 2 AIH has an association with the [[HLA]]-DQB1 and [[HLA]]-DRB1 alleles. | ||
*History of another autoimmune disease: | *History of another [[autoimmune disease]]:<ref name="urlAutoimmune hepatitis - PubMed Health">{{cite web |url=http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001291/#adam_000245.disease.causes |title=Autoimmune hepatitis - PubMed Health |format= |work= |accessdate=2013-01-02}}</ref> | ||
**Autoimmune diseases, including thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis | **Autoimmune diseases, including [[thyroiditis]], [[type 1 diabetes]], [[ulcerative colitis]], [[celiac disease]], and [[rheumatoid arthritis]]. | ||
===Less Common Risk Factors=== | ===Less Common Risk Factors=== | ||
Less common risk factors in the development of Autoimmune hepatitis include: | Less common risk factors in the development of [[Autoimmune hepatitis]] include: | ||
*A history of viral infections:<ref name="pmid14871651">{{cite journal |vauthors=Vento S, Cainelli F |title=Is there a role for viruses in triggering autoimmune hepatitis? |journal=Autoimmun Rev |volume=3 |issue=1 |pages=61–9 |year=2004 |pmid=14871651 |doi=10.1016/S1568-9972(03)00053-3 |url=}}</ref><ref name="pmid7499793">{{cite journal |vauthors=Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH |title=Autoimmune hepatitis following hepatitis A virus infection |journal=J. Hepatol. |volume=23 |issue=2 |pages=204–8 |year=1995 |pmid=7499793 |doi= |url=}}</ref> | *A history of [[viral infections]]:<ref name="pmid14871651">{{cite journal |vauthors=Vento S, Cainelli F |title=Is there a role for viruses in triggering autoimmune hepatitis? |journal=Autoimmun Rev |volume=3 |issue=1 |pages=61–9 |year=2004 |pmid=14871651 |doi=10.1016/S1568-9972(03)00053-3 |url=}}</ref><ref name="pmid7499793">{{cite journal |vauthors=Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH |title=Autoimmune hepatitis following hepatitis A virus infection |journal=J. Hepatol. |volume=23 |issue=2 |pages=204–8 |year=1995 |pmid=7499793 |doi= |url=}}</ref> | ||
**Autoimmune hepatitis is common who are infected with the measles, herpes simplex or Epstein-Barr virus and hepatitis A, B or C infection in the past. | **[[Autoimmune hepatitis]] is common who are infected with the [[measles]], [[herpes simplex]] or [[Epstein Barr virus|epstein-Barr virus]] and [[hepatitis A]], B or C infection in the past. | ||
*History of drug intake: | *History of drug intake:<ref name="pmid20512992">{{cite journal |vauthors=Björnsson E, Talwalkar J, Treeprasertsuk S, Kamath PS, Takahashi N, Sanderson S, Neuhauser M, Lindor K |title=Drug-induced autoimmune hepatitis: clinical characteristics and prognosis |journal=Hepatology |volume=51 |issue=6 |pages=2040–8 |year=2010 |pmid=20512992 |doi=10.1002/hep.23588 |url=}}</ref> | ||
**[[ | **[[minocycline]], [[nitrofurantoin]], [[hydralazine]], [[methyldopa]] [[statins]], [[fenofibrate]], [[interferon]], [[infliximab]], [[etanercept]] increases the risk of [[autoimmune hepatitis]]. | ||
==References== | ==References== | ||
Latest revision as of 17:18, 9 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Common risk factors in the development of autoimmune hepatitis include female gender, Genetic predisposition associated with HLA-DR3 and HLA-DR4, and history of other autoimmune hepatitis eg thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis.
Risk Factors
Common Risk Factors
Common risk factors in the development of autoimmune hepatitis include:
- Females:
- Autoimmune hepatitis is more common in young females.
- Genetic predisposition:[1]
- History of another autoimmune disease:[2]
- Autoimmune diseases, including thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis.
Less Common Risk Factors
Less common risk factors in the development of Autoimmune hepatitis include:
- A history of viral infections:[3][4]
- Autoimmune hepatitis is common who are infected with the measles, herpes simplex or epstein-Barr virus and hepatitis A, B or C infection in the past.
- History of drug intake:[5]
- minocycline, nitrofurantoin, hydralazine, methyldopa statins, fenofibrate, interferon, infliximab, etanercept increases the risk of autoimmune hepatitis.
References
- ↑ Donaldson PT (2004). "Genetics of autoimmune and viral liver diseases; understanding the issues". J. Hepatol. 41 (2): 327–32. doi:10.1016/j.jhep.2004.06.001. PMID 15288484.
- ↑ "Autoimmune hepatitis - PubMed Health". Retrieved 2013-01-02.
- ↑ Vento S, Cainelli F (2004). "Is there a role for viruses in triggering autoimmune hepatitis?". Autoimmun Rev. 3 (1): 61–9. doi:10.1016/S1568-9972(03)00053-3. PMID 14871651.
- ↑ Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH (1995). "Autoimmune hepatitis following hepatitis A virus infection". J. Hepatol. 23 (2): 204–8. PMID 7499793.
- ↑ Björnsson E, Talwalkar J, Treeprasertsuk S, Kamath PS, Takahashi N, Sanderson S, Neuhauser M, Lindor K (2010). "Drug-induced autoimmune hepatitis: clinical characteristics and prognosis". Hepatology. 51 (6): 2040–8. doi:10.1002/hep.23588. PMID 20512992.