ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Identifiers
Symbols	ABCC3 ; ABC31; EST90757; MLP2; MOAT-D; MRP3; cMOAT2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68364
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ATP-binding cassette, sub-family C (CFTR/MRP), member 3, also known as ABCC3, is a human gene.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

See also

• ATP-binding cassette transporter

Further reading

• Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum. Mol. Genet. 5 (10): 1649–55. PMID 8894702.CS1 maint: Multiple names: authors list (link)
• Kool M, de Haas M, Scheffer GL; et al. (1997). "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines". Cancer Res. 57 (16): 3537–47. PMID 9270026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kiuchi Y, Suzuki H, Hirohashi T; et al. (1998). "cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)". FEBS Lett. 433 (1–2): 149–52. PMID 9738950.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uchiumi T, Hinoshita E, Haga S; et al. (1998). "Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport". Biochem. Biophys. Res. Commun. 252 (1): 103–10. PMID 9813153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Belinsky MG, Bain LJ, Balsara BB; et al. (1998). "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". J. Natl. Cancer Inst. 90 (22): 1735–41. PMID 9827529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fromm MF, Leake B, Roden DM; et al. (1999). "Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants". Biochim. Biophys. Acta. 1415 (2): 369–74. PMID 9889399.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• König J, Rost D, Cui Y, Keppler D (1999). "Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane". Hepatology. 29 (4): 1156–63. doi:10.1002/hep.510290404. PMID 10094960.CS1 maint: Multiple names: authors list (link)
• Cole SP (1999). "Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". J. Natl. Cancer Inst. 91 (10): 888–9. PMID 10340910.
• Kool M, van der Linden M, de Haas M; et al. (1999). "MRP3, an organic anion transporter able to transport anti-cancer drugs". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6914–9. PMID 10359813.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ortiz DF, Li S, Iyer R; et al. (1999). "MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte". Am. J. Physiol. 276 (6 Pt 1): G1493–500. PMID 10362653.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takada T, Suzuki H, Sugiyama Y (2000). "Characterization of 5'-flanking region of human MRP3". Biochem. Biophys. Res. Commun. 270 (3): 728–32. doi:10.1006/bbrc.2000.2507. PMID 10772892.CS1 maint: Multiple names: authors list (link)
• Nies AT, König J, Pfannschmidt M; et al. (2002). "Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma". Int. J. Cancer. 94 (4): 492–9. PMID 11745434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tatebe S, Sinicrope FA, Kuo MT (2002). "Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells". Biochem. Biophys. Res. Commun. 290 (5): 1427–33. doi:10.1006/bbrc.2002.6367. PMID 11820781.CS1 maint: Multiple names: authors list (link)
• Scheffer GL, Kool M, de Haas M; et al. (2002). "Tissue distribution and induction of human multidrug resistant protein 3". Lab. Invest. 82 (2): 193–201. PMID 11850532.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zelcer N, Saeki T, Bot I; et al. (2003). "Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter". Biochem. J. 369 (Pt 1): 23–30. doi:10.1042/BJ20021081. PMID 12220224.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hooijberg JH, Peters GJ, Assaraf YG; et al. (2003). "The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis". Biochem. Pharmacol. 65 (5): 765–71. PMID 12628490.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bodo A, Bakos E, Szeri F; et al. (2003). "Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions". J. Biol. Chem. 278 (26): 23529–37. doi:10.1074/jbc.M303515200. PMID 12704183.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.CS1 maint: Multiple names: authors list (link)
• Lang T, Hitzl M, Burk O; et al. (2004). "Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver". Pharmacogenetics. 14 (3): 155–64. PMID 15167703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ABCC3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.