Polycystic kidney disease natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]

Overview

Polycystic kidney disease is a multiorgan and progressive disorder characterized by formation of cysts in kidney and other organs like pancreas, liver and spleen.

Natural History

  • Symptoms of polycystic kidney disease begin in the third or fourth decade of life. However, the renal cysts can be detected as early as childhood or in utero.
  • The cysts gradually grow in size replacing most of the renal tissue, compromising its normal function.
  • Creatinine begins to built up and eventually the patient goes into end stage renal disease.

Complications

Prognosis

  • The disease gets worse slowly. Eventually it leads to end-stage chronic renal failure.
  • It is also associated with liver disease, including infection of liver cysts.
  • Medical treatment may relieve symptoms for many years.
  • People with PKD who do not have other diseases may be good candidates for a kidney transplant.

References

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