Anaplastic large cell lymphoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2], Kamal Akbar, M.D.[3]
Overview
Anaplastic large cell lymphoma may be classified into several subtypes based on immunophenotype, clinical presentation, and histology.
Classification
- Anaplastic large cell lymphoma (peripheral T-cell lymphoma Non-Hodgkin Lymphoma) may be classified into 2 subtypes:
- Based on clinical presentations, anaplastic large cell lymphoma may be classified into 3 subtypes:
- Primary cutaneous anaplastic large cell lymphoma
- Primary systemic anaplastic large cell lymphoma
- Nodal anaplastic large cell lymphoma
- Extra nodal anaplastic large cell lymphoma
- Implant associated anaplastic large cell lymphoma
- Based on histology, anaplastic large cell lymphoma may be classified into 3 subtypes:
- Classical Variants
- Atypical Variants
- Rare Variants
Name | Description |
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Primary cutaneous anaplastic large cell lymphoma |
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Primary systemic anaplastic large cell lymphoma |
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Implant associated anaplastic large cell lymphoma |
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Name | Description | ||||
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Classical Variants | |||||
Common pattern |
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Atypical Variants | |||||
Small cell | |||||
Lymphohistiocytic |
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Giant cell |
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Hodgkin's like |
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Rare Variants | |||||
Sarcomatoid |
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References
- ↑ Miranda RN, Aladily TN, Prince HM, Kanagal-Shamanna R, de Jong D, Fayad LE,Amin MB, Haideri N, Bhagat G, Brooks GS, Shifrin DA, O'Malley DP, Cheah CY, Bacchi CE, Gualco G, Li S, Keech JA Jr, Hochberg EP, Carty MJ, Hanson SE, Mustafa E, Sanchez S, Manning JT Jr, Xu-Monette ZY, Miranda AR, Fox P, Bassett RL, Castillo JJ, Beltran BE, de Boer JP, Chakhachiro Z, Ye D, Clark D, Young KH, Medeiros LJ. Breast implant-associated anaplastic large-cell lymphoma: long-term follow-up of 60 patients. J Clin Oncol. 2014 Jan 10;32(2):114-20.
- ↑ 2.0 2.1 2.2 Swerdlow, Steven (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer. ISBN 9789283224310.
- ↑ Falini B, Bigerna B, Fizzotti M, Pulford K, Pileri SA, Delsol G; et al. (1998). "ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum". Am J Pathol. 153 (3): 875–86. doi:10.1016/S0002-9440(10)65629-5. PMC 1853018. PMID 9736036.
- ↑ Kinney MC, Collins RD, Greer JP, Whitlock JA, Sioutos N, Kadin ME (1993). "A small-cell-predominant variant of primary Ki-1 (CD30)+ T-cell lymphoma". Am J Surg Pathol. 17 (9): 859–68. PMID 8394652.
- ↑ "Frequent Expression ofthe NPM-ALK Chimeric Fusion Protein inAnaplastic Large-Cell Lymphoma, Lympho-Histiocytic Type" (PDF).
- ↑ 6.0 6.1 Vassallo J, Lamant L, Brugieres L, Gaillard F, Campo E, Brousset P; et al. (2006). "ALK-positive anaplastic large cell lymphoma mimicking nodular sclerosis Hodgkin's lymphoma: report of 10 cases". Am J Surg Pathol. 30 (2): 223–9. PMID 16434897.