Anaplastic large cell lymphoma natural history, complications and prognosis
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The ALK-positive anaplastic large cell lymphoma is associated with the most favorable prognosis. ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 70-80%. ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 30-40%.
- If left untreated, patients with Anaplastic large cell lymphoma may progress to develop anemia, intestinal obstruction, and immunospression thus causing Infection.
- Common complications of [disease name] include:
- Organ failure due metastasis
- Immunosuppression thus causing infection
- CNS involvement causing:
- Visual disturbance
- Facial numbness
- Anemia due to bleeding
- Stroke due to vascular occlusion from leukemic cells
- Those with ALK positivity have a better prognosis 
- ALK-negative anaplastic large cell lymphomas represent other T-cell lymphomas in a final common pathway of disease progression
- Overall better prognosis than other "Aggressive Lymphomas"
- ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 70-80%
- ALK-positive anaplastic large cell lymphoma is associated with a 5 year survival rate of 30-40%
- The International Prognostic Iindex (IPI) is used to estimate the prognosis of patients.
- The IPI takes into account 5 variables:
- If any of this criteria is met, one point is awarded for the IPI. The interpretation of the total score is as follows:
- 0 to 1: Low risk
- 2: Low-intermediate risk
- 3: High-intermediate risk
- 4 to 5: High risk
- According to the International Peripheral T cell Lymphoma Project, the estimated 5-years survival for each of the IPI stages are as follows:
- Low risk (IPI 0-1): 90%
- Low-intermediate risk (IPI 2): 68%
- High-intermediate risk (IPI 3): 23%
- High risk (IPI 4-5): 33%
- However, recently, the International peripheral T-cell lymphoma Project score (IPTCLP) has demonstrated to be the most accurate score to predict overall survival in patients. This score includes:
- Eastern Cooperative Oncology Group (ECOG) performance status
- Platelet count
- Agrawal K, Shet T, Sridhar E, Dhende S, Sengar M, Arora B; et al. (2017). "Story of survival in anaplastic large cell lymphoma - sometimes more than the anaplastic lymphoma kinase status: An evaluation of pathologic prognostic factors in 102 cases". Indian J Pathol Microbiol. 60 (4): 533–540. doi:10.4103/IJPM.IJPM_778_15. PMID 29323068.
- "ALK− anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project".
- "Comparison of four prognostic scores in peripheral T-cell lymphoma".