Lactic acidosis: Difference between revisions

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List of terms related to Lactic acidosis

	Lactic acidosis;
	Lactic acid

VisualWikitext

Revision as of 19:57, 12 February 2013

For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Lactate levels raised (plasma or serum); lactic acidemia; lactic acidaemia.

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Lactic acidosis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings

Treatment

Medical Therapy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Related Chapters

Metabolic acidosis

Additional Resources

Clinical Physiology of Acid-Base and Electrolyte Disorders by Rose, Post
Intensive Care Medicine by Irwin and Rippe
The ICU Book by Marino
Cohen R, Woods H. Clinical and Biochemical Aspects of Lactic Acidosis. Blackwell Scientific Publications; 1976. ISBN 0-632-09460-5.

Template:Endocrine, nutritional and metabolic pathology

Template:WikiDoc Sources

@@ Line 10: / Line 10: @@
 {{SK}} Lactate levels raised (plasma or serum); lactic acidemia; lactic acidaemia.
-==Overview==
-'''Lactic acidosis''' is a condition caused by the buildup of [[lactic acid]] in the body. It leads to acidification of the blood ([[acidosis]]), and is considered a distinct form of [[metabolic acidosis]].
+==[[Lactic acidosis overview|Overview]]==
+==[[Lactic acidosis historical perspective|Historical Perspective]]==
+==[[Lactic acidosis classification|Classification]]==
+==[[Lactic acidosis pathophysiology|Pathophysiology]]==
+==[[Lactic acidosis causes|Causes]]==
+==[[Lactic acidosis differential diagnosis|Differentiating Lactic acidosis from other Diseases]]==
+==[[Lactic acidosis epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Lactic acidosis risk factors|Risk Factors]]==
+==[[Lactic acidosis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
+==Diagnosis==
-The cells produce lactic acid when they use [[glucose]] for energy in the absence of adequate [[oxygen]]. If too much lactic acid stays in the body, the balance tips and the person begins to feel ill. The signs of lactic acidosis are deep and rapid breathing, vomiting, and abdominal pain. Lactic acidosis may be caused by [[diabetic ketoacidosis]] or [[liver]] or [[kidney]] disease, as well as some forms of medication (most notably the anti-diabetic drug [[metformin]]).  Some anti-HIV drugs ([[antiretroviral]]s) warn doctors in their prescribing information to regularly watch for symptoms of lactic acidosis caused by [[mitochondrial toxicity]].
+[[Lactic acidosis history and symptoms|History and Symptoms]] | [[Lactic acidosis physical examination|Physical Examination]] | [[Lactic acidosis laboratory findings|Laboratory Findings]]
+==Treatment==
-==Classification==
+[[Lactic acidosis medical therapy|Medical Therapy]] | [[Lactic acidosis primary prevention|Primary Prevention]] | [[Lactic acidosis secondary prevention|Secondary Prevention]] | [[Lactic acidosis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Lactic acidosis future or investigational therapies|Future or Investigational Therapies]]
+==Case Studies==
-The ''Cohen-Woods classification'' (1976) categorises causes of lactic acidosis as follows:
+[[Lactic acidosis case study one|Case #1]]
-* Type A: Decreased perfusion or oxygenation
+==Related Chapters==
-* Type B:
-** B1: Underlying diseases (sometimes causing type A)
-** B2: Medication or intoxication
-** B3: [[Inborn error of metabolism]]
-Lactic acidosis is an underlying process in the development of [[rigor mortis]].  Tissue in the muscles of the deceased resort to anaerobic metabolism in the absence of oxygen and significant amounts of lactic acid are released into the muscle tissue.  This along with the loss of [[adenosine triphosphate|ATP]] causes the muscles to grow stiff.
-==Pathophysiology==
-* [[Lactic Acidosis|Lactic acidosis]] occurs when cells make lactic acid faster than it can be metabolized. <ref>Sailer, Christian, Wasner, Susanne.  Differential Diagnosis Pocket.  Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref>  <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>
-{|
-|-style="background:silver; color:black"
-| '''Reference Range''' ||
-|-style="background:silver; color:black"
-| '''Capillary Blood''' || '''5-15 mg/dl'''
-|- style="background:silver; color:black"
-| '''Deoxygenated Blood''' || '''-16 mg/dl'''
-|-style="background:silver; color:black"
-| '''Cerebrospinal Fluid (CSF)''' || '''11-19 mg/dl'''
-|}
-== Differential diagnosis of underlying causes of lactic acidosis ==
-=== Increased ===
-* Drugs, toxins
-* End-stage [[renal failure]]
-* Fetal compromise during childbirth
-* [[Glycogen storage disease]]
-* [[Heart failure]]
-* Heavy exercise
-* [[Hypothermia]]
-* [[Hypoventilation]] with [[hypercapnia]]
-* [[Hypovolemia]]
-* Infusions
-* [[Leukemia]]
-* [[Hepatic failure|Liver failure]]
-* [[Myocardial Infarction]]
-* Postoperative state
-* [[Seizures]]
-* [[Sepsis]]
-* Severe [[anemia]]
-* Severe [[thiamine deficiency]]
-* [[Tumors]]
-* Uncontrolled [[diabetes mellitus]]
-==See also==
 * [[Metabolic acidosis]]
-==References==
-{{Reflist|2}}
 ==Additional Resources==


Lactic acidosis
Lactic acid

Lactic acidosis: Difference between revisions

Revision as of 19:57, 12 February 2013

Diagnosis

Treatment

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Related Chapters

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