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== Laboratory Findings ==  
== Laboratory Findings ==  
*Labs include
Suggested laboratory studies to order include a toxicology screen
:*Drug screen
:*tox screen
:*dietary screen


===Treatment===
===Treatment===
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===Research===
===Research===
Several universities are researching Nystagmus and are looking for volunteers to take part in research activities.
Several universities are researching Nystagmus and are looking for volunteers to take part in research activities.



Revision as of 15:35, 13 July 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Shankar Kumar, M.B.B.S. [3]]

Overview

Nystagmus is involuntary eye movement that can be part of either the vestibulo-ocular reflex (VOR) or a pathological process. It is characterized by alternating smooth pursuit in one direction and saccadic movement in the other direction.

General overview

Nystagmus can be caused by subsequent foveation of moving objects, pathology, sustained rotation or substance abuse.

The direction of nystagmus is defined by the direction of its quick phase (e.g. a right-beating nystagmus is characterized by a rightward-moving quick phase). The oscillations may occur in the vertical, horizontal or torsional planes, or in any combination. The resulting nystagmus is often named as a gross description of the movement, e.g. downbeat nystagmus, upbeat nystagmus, seesaw nystagmus, periodic alternating nystagmus.

These descriptive names can be misleading however, as many were assigned historically, solely on the basis of subjective clinical examination, which is not sufficient to determine the eyes' true trajectory.

Over the past forty years, however, objective eye movement recording techniques have been applied to the study of nystagmus, and the results have led to a greater accuracy and understanding of the condition.

Nystagmus is not to be confused with other superficially similar-appearing disorders of eye movements (saccadic oscillations) such as opsoclonus or ocular flutter that are composed purely of fast-phase (saccadic) eye movements, while nystagmus is characterised by the combination of a smooth pursuit, which usually acts to take the eye off the point of regard, interspersed with the saccadic movement that serves to bring the eye back on target. Without the use of objective recording techniques, it may be very difficult to distinguish between these conditions.

In medicine, the presence of nystagmus can be benign, or it can indicate an underlying visual or neurological problem. Over forty types of nystagmus have been classified.

Nystagmus and alcohol

In police work, testing for horizontal gaze nystagmus is one of a battery of field sobriety tests used by officers in the field to determine whether a suspect is driving under the influence of alcohol. The test involves observation of the suspect's pupil as it follows a moving object, noting (1) lack of smooth pursuit, (2) distinct and sustained nystagmus at maximum deviation, and (3) the onset of nystagmus prior to 45 degrees. As a rule of thumb, a person's blood alcohol concentration can be estimated by subtracting the angle of onset from 50 degrees. Therefore, a person with an angle of onset of nystagmus at 35 degrees has a blood alcohol concentration of approximately 0.15%.

Pathological nystagmus

When nystagmus occurs without filling its normal function, it is pathologic (deviating from the healthy or normal condition). Pathological nystagmus is the result of damage to one or more components of the vestibular system, including the semicircular canals, otolith organs, and the vestibulocerebellum.

Pathological nystagmus generally causes a degree of vision impairment, although the severity of such impairment varies widely. Sometimes it is the other way around — many blind people have nystagmus, which is one reason that some wear dark glasses.[1]

Prevalence

Nystagmus is a relatively common clinical condition, affecting one in every 5,000 to 10,000 individuals. One survey in Oxfordshire, England identified one in every 670 children by the age of two as manifesting nystagmus. [2]

Variations

  • Peripheral nystagmus occurs as a result of either normal or diseased functional states of the vestibular system and may combine a rotational component with vertical or horizontal eye movements and may be spontaneous, positional or evoked.
    • Positional nystagmus occurs when a persons head is in a specific position. An example of disease state in which this occurs is Benign paroxysmal positional vertigo (BPPV).
    • Gaze Induced nystagmus occurs or is exacerbated as a result of changing one's gaze toward or away from a particular side which has an affected vestibular apparatus.
    • Post Head Shake nystagmus occurs after an imbalance is created between a normal side and a diseased side by stimulation of the vestibular system by rapid shaking of the head.
    • Spontaneous nystagmus is nystagmus that occurs randomly, regardless of the position of the patient's head.
  • Central nystagmus occurs as a result of either normal or abnormal processes not related to the vestibular organ. For example lesions of the midbrain or cerebellum can results in up and down-beat nystagmus.

Causes

The cause for pathological nystagmus may be congenital, idiopathic, secondary to a pre-existing neurological disorder or may be induced temporarily by disorientation (such as on roller coaster rides) or certain drugs (alcohol and other central nervous system depressants and stimulants, such as lithium salts, phenytoin and ecstasy).

Congenital

Congenital nystagmus occurs more frequently than acquired nystagmus. It can be insular or accompany other disorders (such as micro-ophthalmic anomalies or Down's Syndrome). Congential nystagmus itself and is usually mild and non-progressive. The affected persons are not normally aware of their spontaneous eye movements but vision can be impaired depending on the severity of the movements.

  • Infantile:
  • Latent nystagmus
  • Nystagmus blockage syndrome

Acquired

Diseases

Some of the diseases which present nystagmus as a pathological sign are:

Toxic/metabolic

Nystagmus from toxic or metabolic reasons could be the result of e.g.:

Central nervous system disorders

If the pathologic nystagmus is based in the central nervous system (CNS), such as with a cerebellar problem, the nystagmus can be in any direction including horizontal. Purely vertical nystagmus is usually central in origin.

Causes include e.g.:

Other causes

Complete Differential Diagnosis of the Causes of Nystagmus

(By organ system)

Cardiovascular Brain stem stroke, Thalamic haemorrhage, Vertibrobasilar insufficiency
Chemical / poisoning Alcohol, Ecstasy
Dermatologic Albinism
Drug Side Effect Drug induced nystagmus, Barbiturates, Benzodiazepines, Ketamine, Lithium intoxication, Lysergic acid diethylamide, Methylenedioxymethamphetamine, Phencyclidine , Phenytoin, Salicylates
Ear Nose Throat Labyrinthine stimulation, Superior canal dehiscence syndrome, Tullio phenomenon, Benign paroxysmal positional vertigo, Lesions of the vestibular nuclei, Meniere's disease
Endocrine No underlying causes
Environmental Roller coaster rides
Gastroenterologic Perinatal insult
Genetic Noonan syndrome, Aniridia, Congenital nystagmus, Familial exudative vitreoretinopathy, Leber's congenital amaurosis, Persistent tunica vasculosa lentis, Rod monochromatism, Achromatopsia
Hematologic No underlying causes
Iatrogenic Labyrinthine stimulation
Infectious Disease Macular Toxoplasmosis, Syphillis, Encephalitis
Musculoskeletal / Ortho No underlying causes
Neurologic Arnold-Chiari Malformation, Benign paroxysmal positional vertigo, Brain stem stroke, Encephalitis, Horner's Syndrome, Lateral medullary syndrome, Lesions of the anterior vermis of the cerebellum, Lesions of the vestibular nuclei, Medullary lesions, Meniere's disease, Multiple Sclerosis, Parasellar lesion, Pelizaeus-Merzbacher disease, Posterior fossa tumors, Rostral midbrain lesions, Spinocerebellar degeneration, Structural CNS abnormality, Thalamic haemorrhage, Trochlear nerve malfunction, Vertibrobasilar insufficiency, Wernicke Encephalopathy, Achromatopsia, Optic nerve atrophy, Optic nerve coloboma, Optic nerve hypoplasia, Head trauma
Nutritional / Metabolic Wernicke Encephalopathy
Obstetric/Gynecologic No underlying causes
Oncologic Posterior fossa tumors
Opthalmologic Achromatopsia, Aniridia, Congenital Cataracts, Congenital nystagmus, Dissociated nystagmus, Drug induced nystagmus, Early visual deprivation, Extreme lateral gaze, Familial exudative vitreoretinopathy, Foveal hypoplasia, Idiopathic infantile nystagmus, Latent nystagmus, Leber's congenital amaurosis, Monocular visual loss, Nystagmus blockage syndrome, Optic nerve atrophy, Optic nerve coloboma, Optic nerve hypoplasia, Optokinetic, Periodic alternating nystagmus, Persistent tunica vasculosa lentis, Peters anomaly, Posterior persistanthyperplastic primary viterous, Retinitis pigmentosa, Rod monochromatism, Severe Glaucoma, Severe retinopathy of prematurity, Spasmus nutans, Binocular vision loss, Macular Toxoplasmosis, Multiple Sclerosis
Overdose / Toxicity Lithium intoxication
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Multiple Sclerosis
Sexual No underlying causes
Trauma Head trauma
Urologic No underlying causes
Dental No underlying causes
Miscellaneous No underlying causes

Complete list of differential diagnosis of Nystagmus


Diagnosis

Nystagmus is very noticeable, but little recognised. Nystagmus can be clinically investigated by using a number of non-invasive standard tests. The simplest one is Caloric reflex test. In a caloric reflex test, one external auditory meatus is irrigated with warm or cold water. The temperature gradient provokes the stimulation of the vestibulocochlear nerve and the consequent nystagmus.

The resulting movement of the eyes may be recorded and quantified by special devices called electronystagmograph (ENG), which is a form of electrooculography (an electrical method of measuring eye movements using external electrodes) or even less invasive devices called videoonystagmograph (VNG), which is a form of videooculography(VOG) (a video-based method of measuring eye movements using external small cameras built into head masks). Special swinging chairs with electrical controls are also used in this test to induce rotatory nystagmus.


Laboratory Findings

Suggested laboratory studies to order include a toxicology screen

Treatment

Congenital nystagmus has traditionally been viewed as non-treatable, but medications have been discovered in recent years that show promise in some patients. In 1980, researchers discovered that a drug called baclofen could effectively stop periodic alternating nystagmus. Subsequently, gabapentin, an anticonvulsant, was found to cause improvement in about half the patients who received it to relieve symptoms of nystagmus. Other drugs found to be effective against nystagmus in some patients include memantine, levetiracetam, 3,4-diaminopyridine, 4-aminopyridine, and acetazolamide.[4] Several therapeutic approaches, such as contact lenses, drugs, surgery, and low vision rehabilitation can also be used in order to improve visual function.

Clinical trials of a surgery to treat nystagmus (known as tenotomy) concluded in 2001. Tenotomy is being performed regularly at the University of Pittsburgh Children's Hospital and by a handful of surgeons around the world. The surgery developed by Louis F. Dell'Osso Ph.D aims to reduce the eye shaking (oscillations) which in turn tends to improve visual acuity.

Surgery and Device Based Therapy

  • Otolith repositioning maneuvers
  • Refractive lenses to treat amblyopia

Research

Several universities are researching Nystagmus and are looking for volunteers to take part in research activities.

Current UK Research Projects

See also

References

  1. "nystagmus". Retrieved 2007-06-07.
  2. "American Nystagmus Network-About Nystagmus". Retrieved 2007-06-07.
  3. Lindgren, Stefan (1993). Kliniska färdigheter: Informationsutbytet mellan patient och läkare (in Swedish). Lund: Studentlitteratur. ISBN 91-44-37271-X.
  4. Groves, Nancy. Many options to treat nystagmus, more in development. Ophthalmology Times, March 15 2006. [1]


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