Multiple endocrine neoplasia type 2 diagnostic criteria: Difference between revisions
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==Overview== | ==Overview== | ||
According to the [[American Society of Clinical Oncology]], diagnosis of multiple endocrine neoplasia type 2 requires existence of two or more specific [[endocrine tumors]] ([[medullary thyroid carcinoma]], [[pheochromocytoma]], or [[Hyperparathyroidism|parathyroid hyperplasia]]). Multiple endocrine neoplasia type 2 is also diagnosed with four or more cases of [[medullary thyroid carcinoma]] without [[pheochromocytoma]] and [[parathyroid]] [[adenoma]] or if there is early onset of [[medullary thyroid carcinoma]], [[mucosal]] [[Neuroma|neuromas]] of [[lip]]s and [[tongue]], disctinctive facial features with enlarged [[lip]]s and marfanoid body habitus. | According to the [[American Society of Clinical Oncology]], [[diagnosis]] of multiple endocrine neoplasia type 2 requires existence of two or more specific [[endocrine tumors]] ([[medullary thyroid carcinoma]], [[pheochromocytoma]], or [[Hyperparathyroidism|parathyroid hyperplasia]]). Multiple endocrine neoplasia type 2 is also diagnosed with four or more cases of [[medullary thyroid carcinoma]] without [[pheochromocytoma]] and [[parathyroid]] [[adenoma]] or if there is early onset of [[medullary thyroid carcinoma]], [[mucosal]] [[Neuroma|neuromas]] of [[lip]]s and [[tongue]], disctinctive facial features with enlarged [[lip]]s and marfanoid [[Human body|body]] habitus. | ||
==Diagnostic Critera== | ==Diagnostic Critera== | ||
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Revision as of 13:50, 14 June 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
According to the American Society of Clinical Oncology, diagnosis of multiple endocrine neoplasia type 2 requires existence of two or more specific endocrine tumors (medullary thyroid carcinoma, pheochromocytoma, or parathyroid hyperplasia). Multiple endocrine neoplasia type 2 is also diagnosed with four or more cases of medullary thyroid carcinoma without pheochromocytoma and parathyroid adenoma or if there is early onset of medullary thyroid carcinoma, mucosal neuromas of lips and tongue, disctinctive facial features with enlarged lips and marfanoid body habitus.
Diagnostic Critera
The current clinical criteria for detecting Multiple endocrine neoplasia type 2 is as follows:[1]
Clinical criteria for diagnosis of Multiple endocrine neoplasia type 2 |
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Two or more specific endocrine tumors (medullary thyroid carcinoma, pheochromocytoma or parathyroid hyperplasia) |
Familial medullary thyroid carcinoma is diagnosed in families with four or more cases of medullary thyroid carcinoma without pheochromocytoma and parathyroid adenoma |
Multiple endocrine neoplasia type 2b is diagnosed if there is early onset of medullary thyroid carcinoma, mucosal neuromas of lips and tongue, disctinctive facial features with enlarged lips and marfanoid body habitus |