Alpha 1-antitrypsin deficiency medical therapy: Difference between revisions

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* Improving [[lung]] [[Function (biology)|function]]:
* Improving [[lung]] [[Function (biology)|function]]:
**Efforts should be made to improve [[lung]] [[Function (biology)|function]] in [[patients]] with AATD associated [[emphysema]].
**Efforts should be made to improve [[lung]] [[Function (biology)|function]] in [[patients]] with AATD associated [[emphysema]].
**Administration of short-acting [[beta-adrenergic]] agents and [[ipratropium bromide]] [[bronchodilator]] can help maximize [[lung]] [[Function (biology)|function]]. The preferred route of administration is metered-dose [[inhalers]] because they have a lower [[incidence]] of [[adverse effects]] than other [[Routes of administration|routes]]. These [[drugs]] have no long-term effect on [[disease]] progression.
**Administration of short-acting [[beta-adrenergic]] agents and [[ipratropium bromide]] [[bronchodilator]] can help maximize [[lung]] [[Function (biology)|function]]. The preferred route of administration is metered-dose [[inhalers]] because they have a lower [[incidence]] of [[adverse effects]] than other [[Routes of administration|routes]]. These [[drugs]] have no long-term effect on [[disease]] progression.

Latest revision as of 18:02, 22 January 2018

Alpha 1-antitrypsin deficiency Microchapters

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Overview

Historical Perspective

Classification

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Differentiating Alpha 1-antitrypsin deficiency from other Diseases

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]

Overview

Treatment guidelines for AATD include alpha 1 antitrypsin enzyme repletion, smoking cessation, long-acting inhaled bronchodilators, preventive vaccinations against influenza and pneumococcus, pulmonary rehabilitation for patients with functional impairment, supplemental oxygen if needed lung transplantation, treatment of COPD exacerbation in all patients of AATD should include AAT repletion.

Medical Therapy

References

  1. Petrache I, Hajjar J, Campos M (2009). "Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency". Biologics. 3: 193–204. PMC 2726081. PMID 19707408.
  2. Edgar RG, Patel M, Bayliss S, Crossley D, Sapey E, Turner AM (2017). "Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review". Int J Chron Obstruct Pulmon Dis. 12: 1295–1308. doi:10.2147/COPD.S130440. PMC 5422329. PMID 28496314.


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