Alpha 1-antitrypsin deficiency medical therapy

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Alpha 1-antitrypsin deficiency Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]

Overview

Treatment guidelines for AATD include alpha 1 antitrypsin enzyme repletion, smoking cessation, long-acting inhaled bronchodilators, preventive vaccinations against influenza and pneumococcus, pulmonary rehabilitation for patients with functional impairment, supplemental oxygen if needed lung transplantation, treatment of COPD exacerbation in all patients of AATD should include AAT repletion.

Medical Therapy

References

  1. Petrache I, Hajjar J, Campos M (2009). "Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency". Biologics. 3: 193–204. PMC 2726081. PMID 19707408.
  2. Edgar RG, Patel M, Bayliss S, Crossley D, Sapey E, Turner AM (2017). "Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review". Int J Chron Obstruct Pulmon Dis. 12: 1295–1308. doi:10.2147/COPD.S130440. PMC 5422329. PMID 28496314.



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