SLC14A1: Difference between revisions

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{{Infobox_gene}}
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'''Urea transporter, erythrocyte''' is a [[protein]] that in humans is encoded by the ''SLC14A1'' [[gene]].<ref name="pmid7797558">{{cite journal | vauthors = Olives B, Mattei MG, Huet M, Neau P, Martial S, Cartron JP, Bailly P | title = Kidd blood group and urea transport function of human erythrocytes are carried by the same protein | journal = J Biol Chem | volume = 270 | issue = 26 | pages = 15607–10 |date=Aug 1995 | pmid = 7797558 | pmc =  | doi =10.1074/jbc.270.26.15607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6563| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =  
| Name = Solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
| HGNCid = 10918
| Symbol = SLC14A1
| AltSymbols =; FLJ33745; FLJ41687; HUT11; HsT1341; JK; RACH1; UT-B1; UT1; UTE
| OMIM = 111000
| ECnumber = 
| Homologene = 9285
| MGIid = 1351654
| GeneAtlas_image1 = PBB_GE_SLC14A1_205856_at_tn.png
| Function = {{GNF_GO|id=GO:0005372 |text = water transporter activity}} {{GNF_GO|id=GO:0015204 |text = urea transporter activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006833 |text = water transport}} {{GNF_GO|id=GO:0015840 |text = urea transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6563
    | Hs_Ensembl = ENSG00000141469
    | Hs_RefseqProtein = NP_056949
    | Hs_RefseqmRNA = NM_015865
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 41558157
    | Hs_GenLoc_end = 41585046
    | Hs_Uniprot = Q13336
    | Mm_EntrezGene = 108052
    | Mm_Ensembl = ENSMUSG00000059336
    | Mm_RefseqmRNA = NM_028122
    | Mm_RefseqProtein = NP_082398
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 78262167
    | Mm_GenLoc_end = 78285398
    | Mm_Uniprot = Q5RJG2
  }}
}}
'''Solute carrier family 14 (urea transporter), member 1 (Kidd blood group)''', also known as '''SLC14A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6563| accessdate = }}</ref>
 
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==See also==
==Function==
* [[Solute carrier family]]
The SLC14A1 codes for a [[urea transporter]] (UTB) that is expressed in [[erythrocyte]]s and [[kidney]]. [[SLC14A2]] and SLC14A1 constitute [[solute carrier family]] 14. UTB proteins constitute the [[Kidd antigen system]].


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Geitvik GA, Høyheim B, Gedde-Dahl T, ''et al.'' |title=The Kidd (JK) blood group locus assigned to chromosome 18 by close linkage to a DNA-RFLP. |journal=Hum. Genet. |volume=77 |issue= 3 |pages= 205-9 |year= 1987 |pmid= 2890568 |doi= }}
*{{cite journal   |vauthors=Geitvik GA, Høyheim B, Gedde-Dahl T, etal |title=The Kidd (JK) blood group locus assigned to chromosome 18 by close linkage to a DNA-RFLP. |journal=Hum. Genet. |volume=77 |issue= 3 |pages= 205–9 |year= 1987 |pmid= 2890568 |doi=10.1007/BF00284470 }}
*{{cite journal  | author=Olivès B, Mattei MG, Huet M, ''et al.'' |title=Kidd blood group and urea transport function of human erythrocytes are carried by the same protein. |journal=J. Biol. Chem. |volume=270 |issue= 26 |pages= 15607-10 |year= 1995 |pmid= 7797558 |doi= }}
*{{cite journal   |vauthors=Olives B, Neau P, Bailly P, etal |title=Cloning and functional expression of a urea transporter from human bone marrow cells. |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 31649–52 |year= 1995 |pmid= 7989337 |doi=  }}
*{{cite journal | author=Olives B, Neau P, Bailly P, ''et al.'' |title=Cloning and functional expression of a urea transporter from human bone marrow cells. |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 31649-52 |year= 1995 |pmid= 7989337 |doi=  }}
*{{cite journal  | vauthors=Davey S, Beach D |title=RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation. |journal=Mol. Biol. Cell |volume=6 |issue= 10 |pages= 1411–21 |year= 1996 |pmid= 8573795 |doi= 10.1091/mbc.6.10.1411| pmc=301296 }}
*{{cite journal  | author=Davey S, Beach D |title=RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation. |journal=Mol. Biol. Cell |volume=6 |issue= 10 |pages= 1411-21 |year= 1996 |pmid= 8573795 |doi=  }}
*{{cite journal   |vauthors=Olivès B, Martial S, Mattei MG, etal |title=Molecular characterization of a new urea transporter in the human kidney. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 156–60 |year= 1996 |pmid= 8647271 |doi=10.1016/0014-5793(96)00425-5 }}
*{{cite journal | author=Olivès B, Martial S, Mattei MG, ''et al.'' |title=Molecular characterization of a new urea transporter in the human kidney. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 156-60 |year= 1996 |pmid= 8647271 |doi=  }}
*{{cite journal   |vauthors=Olivès B, Merriman M, Bailly P, etal |title=The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility. |journal=Hum. Mol. Genet. |volume=6 |issue= 7 |pages= 1017–20 |year= 1997 |pmid= 9215669 |doi=10.1093/hmg/6.7.1017 }}
*{{cite journal | author=Olivès B, Merriman M, Bailly P, ''et al.'' |title=The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility. |journal=Hum. Mol. Genet. |volume=6 |issue= 7 |pages= 1017-20 |year= 1997 |pmid= 9215669 |doi=  }}
*{{cite journal   |vauthors=Lucien N, Sidoux-Walter F, Olivès B, etal |title=Characterization of the gene encoding the human Kidd blood group/urea transporter protein. Evidence for splice site mutations in Jknull individuals. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 12973–80 |year= 1998 |pmid= 9582331 |doi=10.1074/jbc.273.21.12973 }}
*{{cite journal | author=Lucien N, Sidoux-Walter F, Olivès B, ''et al.'' |title=Characterization of the gene encoding the human Kidd blood group/urea transporter protein. Evidence for splice site mutations in Jknull individuals. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 12973-80 |year= 1998 |pmid= 9582331 |doi=  }}
*{{cite journal  | vauthors=Irshaid NM, Thuresson B, Olsson ML |title=Genomic typing of the Kidd blood group locus by a single-tube allele-specific primer PCR technique. |journal=Br. J. Haematol. |volume=102 |issue= 4 |pages= 1010–4 |year= 1998 |pmid= 9734652 |doi=10.1046/j.1365-2141.1998.00874.x }}
*{{cite journal  | author=Irshaid NM, Thuresson B, Olsson ML |title=Genomic typing of the Kidd blood group locus by a single-tube allele-specific primer PCR technique. |journal=Br. J. Haematol. |volume=102 |issue= 4 |pages= 1010-4 |year= 1998 |pmid= 9734652 |doi=  }}
*{{cite journal   |vauthors=Sidoux-Walter F, Lucien N, Olivès B, etal |title=At physiological expression levels the Kidd blood group/urea transporter protein is not a water channel. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30228–35 |year= 1999 |pmid= 10514515 |doi=10.1074/jbc.274.42.30228 }}
*{{cite journal | author=Sidoux-Walter F, Lucien N, Olivès B, ''et al.'' |title=At physiological expression levels the Kidd blood group/urea transporter protein is not a water channel. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30228-35 |year= 1999 |pmid= 10514515 |doi=  }}
*{{cite journal  | vauthors=Irshaid NM, Henry SM, Olsson ML |title=Genomic characterization of the kidd blood group gene:different molecular basis of the Jk(a-b-) phenotype in Polynesians and Finns. |journal=Transfusion |volume=40 |issue= 1 |pages= 69–74 |year= 2000 |pmid= 10644814 |doi=10.1046/j.1537-2995.2000.40010069.x }}
*{{cite journal  | author=Irshaid NM, Henry SM, Olsson ML |title=Genomic characterization of the kidd blood group gene:different molecular basis of the Jk(a-b-) phenotype in Polynesians and Finns. |journal=Transfusion |volume=40 |issue= 1 |pages= 69-74 |year= 2000 |pmid= 10644814 |doi=  }}
*{{cite journal   |vauthors=Sidoux-Walter F, Lucien N, Nissinen R, etal |title=Molecular heterogeneity of the Jk(null) phenotype: expression analysis of the Jk(S291P) mutation found in Finns. |journal=Blood |volume=96 |issue= 4 |pages= 1566–73 |year= 2000 |pmid= 10942407 |doi=  }}
*{{cite journal | author=Sidoux-Walter F, Lucien N, Nissinen R, ''et al.'' |title=Molecular heterogeneity of the Jk(null) phenotype: expression analysis of the Jk(S291P) mutation found in Finns. |journal=Blood |volume=96 |issue= 4 |pages= 1566-73 |year= 2000 |pmid= 10942407 |doi=  }}
*{{cite journal  | vauthors=Lucien N, Chiaroni J, Cartron JP, Bailly P |title=Partial deletion in the JK locus causing a Jk(null) phenotype. |journal=Blood |volume=99 |issue= 3 |pages= 1079–81 |year= 2002 |pmid= 11807016 |doi=10.1182/blood.V99.3.1079 }}
*{{cite journal  | author=Lucien N, Chiaroni J, Cartron JP, Bailly P |title=Partial deletion in the JK locus causing a Jk(null) phenotype. |journal=Blood |volume=99 |issue= 3 |pages= 1079-81 |year= 2002 |pmid= 11807016 |doi=  }}
*{{cite journal   |vauthors=Irshaid NM, Eicher NI, Hustinx H, etal |title=Novel alleles at the JK blood group locus explain the absence of the erythrocyte urea transporter in European families. |journal=Br. J. Haematol. |volume=116 |issue= 2 |pages= 445–53 |year= 2002 |pmid= 11841450 |doi=10.1046/j.1365-2141.2002.03238.x }}
*{{cite journal | author=Irshaid NM, Eicher NI, Hustinx H, ''et al.'' |title=Novel alleles at the JK blood group locus explain the absence of the erythrocyte urea transporter in European families. |journal=Br. J. Haematol. |volume=116 |issue= 2 |pages= 445-53 |year= 2002 |pmid= 11841450 |doi=  }}
*{{cite journal   |vauthors=Lucien N, Sidoux-Walter F, Roudier N, etal |title=Antigenic and functional properties of the human red blood cell urea transporter hUT-B1. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34101–8 |year= 2002 |pmid= 12093813 |doi= 10.1074/jbc.M205073200 }}
*{{cite journal | author=Lucien N, Sidoux-Walter F, Roudier N, ''et al.'' |title=Antigenic and functional properties of the human red blood cell urea transporter hUT-B1. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34101-8 |year= 2002 |pmid= 12093813 |doi= 10.1074/jbc.M205073200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Inoue H, Jackson SD, Vikulina T, etal |title=Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon. |journal=Am. J. Physiol., Cell Physiol. |volume=287 |issue= 1 |pages= C30–5 |year= 2004 |pmid= 14985236 |doi= 10.1152/ajpcell.00443.2003 }}
*{{cite journal | author=Inoue H, Jackson SD, Vikulina T, ''et al.'' |title=Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon. |journal=Am. J. Physiol., Cell Physiol. |volume=287 |issue= 1 |pages= C30-5 |year= 2004 |pmid= 14985236 |doi= 10.1152/ajpcell.00443.2003 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
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[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
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{{membrane-protein-stub}}

Latest revision as of 06:26, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Urea transporter, erythrocyte is a protein that in humans is encoded by the SLC14A1 gene.[1][2]


Function

The SLC14A1 codes for a urea transporter (UTB) that is expressed in erythrocytes and kidney. SLC14A2 and SLC14A1 constitute solute carrier family 14. UTB proteins constitute the Kidd antigen system.

References

  1. ↑ Olives B, Mattei MG, Huet M, Neau P, Martial S, Cartron JP, Bailly P (Aug 1995). "Kidd blood group and urea transport function of human erythrocytes are carried by the same protein". J Biol Chem. 270 (26): 15607–10. doi:10.1074/jbc.270.26.15607. PMID 7797558.
  2. ↑ "Entrez Gene: SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)".

Further reading


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