SLC9A5: Difference between revisions

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Revision as of 03:59, 27 October 2017

Sodium–hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.^[1]^[2]^[3]

References

↑ Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M, et al. (Jun 1995). "Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1". Genomics. 25 (3): 615–22. doi:10.1016/0888-7543(95)80002-4. PMID 7759094.
↑ Attaphitaya S, Park K, Melvin JE (Mar 1999). "Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain". J Biol Chem. 274 (7): 4383–8. doi:10.1074/jbc.274.7.4383. PMID 9933642.
↑ "Entrez Gene: SLC9A5 solute carrier family 9 (sodium/hydrogen exchanger), member 5".

Baird NR, Orlowski J, Szabó EZ, et al. (1999). "Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain". J. Biol. Chem. 274 (7): 4377–82. doi:10.1074/jbc.274.7.4377. PMID 9933641.
Szaszi K, Paulsen A, Szabo EZ, et al. (2003). "Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton". J. Biol. Chem. 277 (45): 42623–32. doi:10.1074/jbc.M206629200. PMID 12205089.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
Inoue H, Nakamura Y, Nagita M, et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
Lin WM, Chen XH, Xu R, et al. (2003). "[Tissue-specific expression of Na(+)-H(+) exchanger isoforms at two developmental stages of human fetus]". Sheng li xue bao : [Acta physiologica Sinica]. 55 (1): 79–82. PMID 12598940.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Szabó EZ, Numata M, Lukashova V, et al. (2005). "beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2790–5. doi:10.1073/pnas.0407444102. PMC 549460. PMID 15699339.
Onishi I, Lin PJ, Diering GH, et al. (2007). "RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity". Cell. Signal. 19 (1): 194–203. doi:10.1016/j.cellsig.2006.06.011. PMID 16920332.

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[pmid7759094-1] Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M, et al. (Jun 1995). "Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1". Genomics. 25 (3): 615–22. doi:10.1016/0888-7543(95)80002-4. PMID 7759094.

[pmid9933642-2] Attaphitaya S, Park K, Melvin JE (Mar 1999). "Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain". J Biol Chem. 274 (7): 4383–8. doi:10.1074/jbc.274.7.4383. PMID 9933642.

[entrez-3] "Entrez Gene: SLC9A5 solute carrier family 9 (sodium/hydrogen exchanger), member 5".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
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+'''Sodium–hydrogen exchanger 5''' is a [[protein]] that in humans is encoded by the ''SLC9A5'' [[gene]].<ref name="pmid7759094">{{cite journal  |vauthors=Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M, etal | title = Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1 | journal = Genomics | volume = 25 | issue = 3 | pages = 615–22 |date=Jun 1995 | pmid = 7759094 | pmc =  | doi =10.1016/0888-7543(95)80002-4  }}</ref><ref name="pmid9933642">{{cite journal | vauthors = Attaphitaya S, Park K, Melvin JE | title = Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain | journal = J Biol Chem | volume = 274 | issue = 7 | pages = 4383–8 |date=Mar 1999 | pmid = 9933642 | pmc =  | doi =10.1074/jbc.274.7.4383  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC9A5 solute carrier family 9 (sodium/hydrogen exchanger), member 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6553| accessdate = }}</ref>
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-  | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 9 (sodium/hydrogen exchanger), member 5
- | HGNCid = 11078
- | Symbol = SLC9A5
- | AltSymbols =; NHE5
- | OMIM = 600477
- | ECnumber =
- | Homologene = 31247
- | MGIid = 2685542
-  | GeneAtlas_image1 = PBB_GE_SLC9A5_220650_s_at_tn.png
-  | Function = {{GNF_GO|id=GO:0015297 |text = antiporter activity}} {{GNF_GO|id=GO:0015299 |text = solute:hydrogen antiporter activity}} {{GNF_GO|id=GO:0015385 |text = sodium:hydrogen antiporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006885 |text = regulation of pH}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6553
-    | Hs_Ensembl = ENSG00000135740
-    | Hs_RefseqProtein = NP_004585
-    | Hs_RefseqmRNA = NM_004594
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 16
-    | Hs_GenLoc_start = 65840354
-    | Hs_GenLoc_end = 65863594
-    | Hs_Uniprot = Q14940
-    | Mm_EntrezGene = 277973
-    | Mm_Ensembl = ENSMUSG00000014786
-    | Mm_RefseqmRNA = XM_894890
-    | Mm_RefseqProtein = XP_899983
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 8
-    | Mm_GenLoc_start = 108238414
-    | Mm_GenLoc_end = 108257601
-    | Mm_Uniprot =
-  }}
-}}
-'''Solute carrier family 9 (sodium/hydrogen exchanger), member 5''', also known as '''SLC9A5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC9A5 solute carrier family 9 (sodium/hydrogen exchanger), member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6553| accessdate = }}</ref>
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@@ Line 58: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 64: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Klanke CA, Su YR, Callen DF, ''et al.'' |title=Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. |journal=Genomics |volume=25 |issue= 3 |pages= 615-22 |year= 1995 |pmid= 7759094 |doi=  }}
+*{{cite journal   |vauthors=Baird NR, Orlowski J, Szabó EZ, etal |title=Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4377–82 |year= 1999 |pmid= 9933641 |doi=10.1074/jbc.274.7.4377  }}
-*{{cite journal  | author=Baird NR, Orlowski J, Szabó EZ, ''et al.'' |title=Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4377-82 |year= 1999 |pmid= 9933641 |doi=  }}
+*{{cite journal   |vauthors=Szaszi K, Paulsen A, Szabo EZ, etal |title=Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42623–32 |year= 2003 |pmid= 12205089 |doi= 10.1074/jbc.M206629200 }}
-*{{cite journal  | author=Attaphitaya S, Park K, Melvin JE |title=Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4383-8 |year= 1999 |pmid= 9933642 |doi=  }}
+*{{cite journal   |vauthors=Chagnon P, Michaud J, Mitchell G, etal |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443–9 |year= 2003 |pmid= 12417987 |doi=10.1086/344580  | pmc=378590  }}
-*{{cite journal  | author=Szaszi K, Paulsen A, Szabo EZ, ''et al.'' |title=Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42623-32 |year= 2003 |pmid= 12205089 |doi= 10.1074/jbc.M206629200 }}
+*{{cite journal   |vauthors=Inoue H, Nakamura Y, Nagita M, etal |title=Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. |journal=Biol. Pharm. Bull. |volume=26 |issue= 2 |pages= 148–55 |year= 2003 |pmid= 12576672 |doi=10.1248/bpb.26.148  }}
-*{{cite journal  | author=Chagnon P, Michaud J, Mitchell G, ''et al.'' |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443-9 |year= 2003 |pmid= 12417987 |doi=  }}
+*{{cite journal   |vauthors=Lin WM, Chen XH, Xu R, etal |title=[Tissue-specific expression of Na(+)-H(+) exchanger isoforms at two developmental stages of human fetus] |journal=Sheng li xue bao : [Acta physiologica Sinica] |volume=55 |issue= 1 |pages= 79–82 |year=  2003|pmid= 12598940 |doi=  }}
-*{{cite journal  | author=Inoue H, Nakamura Y, Nagita M, ''et al.'' |title=Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. |journal=Biol. Pharm. Bull. |volume=26 |issue= 2 |pages= 148-55 |year= 2003 |pmid= 12576672 |doi=  }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Lin WM, Chen XH, Xu R, ''et al.'' |title=[Tissue-specific expression of Na(+)-H(+) exchanger isoforms at two developmental stages of human fetus] |journal=Sheng li xue bao : [Acta physiologica Sinica] |volume=55 |issue= 1 |pages= 79-82 |year=  |pmid= 12598940 |doi=  }}
+*{{cite journal   |vauthors=Szabó EZ, Numata M, Lukashova V, etal |title=beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 8 |pages= 2790–5 |year= 2005 |pmid= 15699339 |doi= 10.1073/pnas.0407444102  | pmc=549460 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Onishi I, Lin PJ, Diering GH, etal |title=RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity. |journal=Cell. Signal. |volume=19 |issue= 1 |pages= 194–203 |year= 2007 |pmid= 16920332 |doi= 10.1016/j.cellsig.2006.06.011 }}
-*{{cite journal  | author=Szabó EZ, Numata M, Lukashova V, ''et al.'' |title=beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 8 |pages= 2790-5 |year= 2005 |pmid= 15699339 |doi= 10.1073/pnas.0407444102 }}
-*{{cite journal  | author=Onishi I, Lin PJ, Diering GH, ''et al.'' |title=RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity. |journal=Cell. Signal. |volume=19 |issue= 1 |pages= 194-203 |year= 2007 |pmid= 16920332 |doi= 10.1016/j.cellsig.2006.06.011 }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
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+{{PBB_Controls
+| update_page = yes
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+| update_protein_box = yes
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+| update_citations = yes
+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC9A5: Difference between revisions

Revision as of 03:59, 27 October 2017

See also

References

Further reading

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