Multiple endocrine neoplasia type 2 other imaging findings: Difference between revisions
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====Octreotide (somatostatin) scans==== | ====Octreotide (somatostatin) scans==== | ||
* Over 70% of [[tumor]]s express [[somatostatin]] receptors. Imaging is obtained 4 hours (+/- 24/48 hours) after an [[intravenous infusion]]. Unfortunately the [[kidney]] also has [[somatostatin receptor]]s, as | * Over 70% of [[tumor]]s express [[somatostatin]] receptors. Imaging is obtained 4 hours (+/- 24/48 hours) after an [[intravenous infusion]]. Unfortunately the [[kidney]] also has [[somatostatin receptor]]s, as well as areas of [[inflammation]], [[mammary gland]]s, [[liver]], [[spleen]], [[bowel]], [[gallbladder]], [[thyroid gland]] and [[salivary gland]]s.<ref>{{cite book | last = Pacak | first = Karel | title = Pheochromocytoma diagnosis, localization, and treatment | publisher = Blackwell Pub | location = Malden, MA Oxford | year = 2007 | isbn = 1405149507 }}</ref> | ||
* [[Octreotide]] is usually labeled with either 111In-DTPA (Octreoscan) or (less commonly)123I-Tyr3-DTPA. | * [[Octreotide]] is usually labeled with either 111In-DTPA (Octreoscan) or (less commonly)123I-Tyr3-DTPA. | ||
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===Parathyroid Carcinoma=== | ===Parathyroid Carcinoma=== | ||
* 99mTc-sestamibi scintigraphy is a good imaging modality for [[hyperparathyroidism]]. | * [[Tc-99m sestamibi scintigraphy|99mTc-sestamibi scintigraphy]] is a good imaging modality for [[hyperparathyroidism]]. | ||
<gallery> | <gallery> | ||
Image:Nuclear medicine.jpg|Image courtesy of Dr Hani Al Salami<ref name=radio01>Image courtesy of Dr Hani Al Salami. [http://www.radiopaedia.org Radiopaedia] (original file[http://radiopaedia.org/cases/7932‘’here’’]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC]</ref> | Image:Nuclear medicine.jpg|Image courtesy of Dr Hani Al Salami<ref name=radio01>Image courtesy of Dr Hani Al Salami. [http://www.radiopaedia.org Radiopaedia] (original file[http://radiopaedia.org/cases/7932‘’here’’]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC]</ref> | ||
Revision as of 15:30, 25 October 2017
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Multiple endocrine neoplasia type 2 Microchapters |
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Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
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Diagnosis |
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Treatment |
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Multiple endocrine neoplasia type 2 other imaging findings On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [4]
Overview
Other imaging studies for multiple endocrine neoplasia type 2 include fluoro-di-glucose-PET, [18F]-fluorodopamine ([18F]DA) PET, and 99mTc-sestamibi scintigraphy.
Other Imaging Studies
Medullary Thyroid Carcinoma
- Radioactive iodine: Lesions do not concentrate radioactive iodine since the tumor does not arise from thyroid follicular cells
- FDG-PET: Avid uptake[1]
- Tl-201: It has been shown to concentrate Thallium-201[2]
- I-123 MIBG (metaiodobenzylguanidine): 30% of medullary thyroid cancer show uptake if the thyroid is blocked with Lugol solution prior to the scan
Pheochromocytoma
- [18F]-fluorodopamine ([18F]DA) PET is the best imaging modality for pheochromocytoma
I-123 MIBG (metaiodobenzylguanidine)
- MIBG (123I- or 131I- metaiodobenzylguanidine) scintigraphy is another imaging modality for pheochromocytoma
Octreotide (somatostatin) scans
- Over 70% of tumors express somatostatin receptors. Imaging is obtained 4 hours (+/- 24/48 hours) after an intravenous infusion. Unfortunately the kidney also has somatostatin receptors, as well as areas of inflammation, mammary glands, liver, spleen, bowel, gallbladder, thyroid gland and salivary glands.[3]
- Octreotide is usually labeled with either 111In-DTPA (Octreoscan) or (less commonly)123I-Tyr3-DTPA.
PET
Parathyroid Carcinoma
- 99mTc-sestamibi scintigraphy is a good imaging modality for hyperparathyroidism.
![Image courtesy of Dr Hani Al Salami[5]](/index.php/File:Nuclear_medicine.jpg)
![Image courtesy of Dr Roberto Schubert[6]](/index.php/File:Nuclear_medicine_02.jpg)
References
- ↑ "Radiopedia 2015 Medullary throid carcinoma [Dr Matt A. Morgan and Dr Yuranga Weerakkody]".
- ↑ Talpos GB, Jackson CE, Froelich JW, Kambouris AA, Block MA, Tashjian AH (1985). "Localization of residual medullary thyroid cancer by thallium/technetium scintigraphy". Surgery. 98 (6): 1189–96. PMID 2866591.
- ↑ Pacak, Karel (2007). Pheochromocytoma diagnosis, localization, and treatment. Malden, MA Oxford: Blackwell Pub. ISBN 1405149507.
- ↑ Hoegerle S, Nitzsche E, Altehoefer C, Ghanem N, Manz T, Brink I; et al. (2002). "Pheochromocytomas: detection with 18F DOPA whole body PET--initial results." Radiology. 222 (2): 507–12. doi:10.1148/radiol.2222010622. PMID 11818620.
- ↑ Image courtesy of Dr Hani Al Salami. Radiopaedia (original file[1]).Creative Commons BY-SA-NC
- ↑ Image courtesy of Dr Roberto Schubert. Radiopaedia (original file[2]).Creative Commons BY-SA-NC