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{{Anaplastic large cell lymphoma}}
{{Anaplastic large cell lymphoma}}
{{CMG}}
{{CMG}}; {{AE}} {{AS}}
==Overview==
==Medical Therapy==
==Medical Therapy==
* Managed under "Aggressive Lymphoma" guidelines
===Chemotherapy===
** [[CHOP]] is first line of treatment, CHOP-[[Rituxan]] in the unlikely scenario that [[CD20]] is positive, given that CD20 is a [[B-cell]] marker.
 
** [[Radiation therapy]] as per institutional preference (based on ECOG, SWOG, and GELA trials), but usually added for bulky disease
Anaplastic large cell lymphoma usually responds well to chemotherapy, so it often has a good prognosis. It is treated with the same combinations of chemotherapy drugs used to treat other aggressive lymphomas.
* Drug Regimen:(CHOP)[[Cyclophosphamide]], {{and}} [[Doxorubicin]], {{and}} [[Vincristine]], {{and}} [[Prednisone]]
===Radiation therapy===
* Radiation therapy is most often given after chemotherapy
* External beam radiation therapy may be used
:* When the lymphoma cells are only in one area of the lymph nodes (stage I primary systemic anaplastic large cell lymphoma)  
:* For localized skin lesions in primary cutaneous anaplastic large cell lymphoma
 
 
 
* Overall better prognosis than other "Aggressive Lymphomas"
* Overall better prognosis than other "Aggressive Lymphomas"
** ALK+ 5-year survival 70-80%
** ALK+ 5-year survival 70-80%

Revision as of 15:10, 6 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Medical Therapy

Chemotherapy

Anaplastic large cell lymphoma usually responds well to chemotherapy, so it often has a good prognosis. It is treated with the same combinations of chemotherapy drugs used to treat other aggressive lymphomas.

Radiation therapy

  • Radiation therapy is most often given after chemotherapy
  • External beam radiation therapy may be used
  • When the lymphoma cells are only in one area of the lymph nodes (stage I primary systemic anaplastic large cell lymphoma)
  • For localized skin lesions in primary cutaneous anaplastic large cell lymphoma


  • Overall better prognosis than other "Aggressive Lymphomas"
    • ALK+ 5-year survival 70-80%
    • ALK- 5-year survival 30-40%

References

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