Loefflers syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

A complete blood count (CBC) with differential may show increased white blood cells, particularly eosinophils. In Loeffler syndrome eosinophilia is generally mild to moderate, usually 5-20%. On the other hand, in certain types of pulmonary eosinophilia, higher percentages are reported. For example, in drug-induced eosinophilia, eosinophils may account for as much as 40% of the WBCs. Generally, the result of stool examination is negative at the time of the Loeffler syndrome presentation. Nevertheless, parasites and ova can be found in the stool 6-12 weeks after the initial parasitic infection. Pulmonary symptoms usually have been resolved when parasitic forms are found in the stool. Immunoglobulin E (IgE) level might be elevated. A bronchoscopy with bronchoalveolar lavage may show increased eosinophilic count. Sputum analysis or gastric lavage may occasionally show Larvae of Ascaris or the other parasites with pulmonary cycle.

Laboratory Findings

• CBC diff

• A complete blood count (CBC) with differential may show increased white blood cells, particularly eosinophils.
• In Loeffler syndrome eosinophilia is generally mild to moderate, usually 5-20%.
• On the other hand, in certain types of pulmonary eosinophilia, higher percentages are reported.
• For example, in drug-induced eosinophilia, eosinophils may account for as much as 40% of the WBCs.

• Stool exam

• Generally the result of stool examination is negative at the time of the Loeffler syndrome presentation.
• Nevertheless, parasites and ova can be found in the stool 6-12 weeks after the initial parasitic infection.
• Pulmonary symptoms usually have been resolved when parasitic forms are found in the stool.

• Immunoglobulin E (IgE) level

• Might be elevated.

• Bronchoscopy and bronchoalveolar lavage

• A bronchoscopy with bronchoalveolar lavage may show increased eosinophilic count.

• Sputum analysis or gastric lavage

• Sputum analysis or gastric lavage may occasionally show Larvae of Ascaris or the other parasites with pulmonary cycle.