Loefflers syndrome chest x ray

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]

Overview

A chest x-ray may be helpful in the diagnosis of Löffler syndrome. Findings on an x-ray suggestive of Löffler syndrome include migratory densities. Chest x-ray usually shows abnormal shadows that can be unilateral or bilateral. Generally, densities are peripheral and present with both interstitial and alveolar pattern (at the same time), they are a few centimeters in diameter, and are transient, migratory, and disappear completely within 2-4 weeks. Pleural effusions is not common in Loeffler syndrome, but there are reports of pleural effusion in patients with drug-induced pulmonary eosinophilia. (nitrofurantoin, valproic acid)


X Ray

An x-ray may be helpful in the diagnosis of Löffler syndrome. Findings on an x-ray suggestive of Löffler syndrome include:[1][2][1][3] [4][5][6][7][8]

  • Chest x-ray usually shows abnormal shadows that can be unilateral or bilateral.
  • Generally peripheral densities
  • Present with both interstitial and alveolar pattern (at the same time).
  • Usually a few centimeters in diameter, but larger areas of consolidation are possible
  • Generally transient, migratory, and disappear completely within 2-4 weeks.
  • Pleural effusions is not common in Loeffler syndrome, but there are reports of pleural effusion in patients with drug-induced pulmonary eosinophilia. (nitrofurantoin, valproic acid)
Acute eosinophilic pneumonia. Case courtesy of Dr Yair Glick, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/53840">rID: 53840</a>
Allergic bronchopulmonary aspergillosis (ABPA). Case courtesy of A.Prof Frank Gaillard, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/15388">rID: 15388</a>

Follow-up

  • 4-6 weeks after initial presentation: Repeat chest radiography (document resolution of pulmonary infiltrates)

References

  1. 1.0 1.1 Te Booij M, de Jong E, Bovenschen HJ (2010) Löffler syndrome caused by extensive cutaneous larva migrans: a case report and review of the literature. Dermatol Online J 16 (10):2. PMID: 21062596
  2. Chitkara RK, Krishna G (2006) Parasitic pulmonary eosinophilia. Semin Respir Crit Care Med 27 (2):171-84. DOI:10.1055/s-2006-939520 PMID: 16612768
  3. Ekin S, Sertogullarindan B, Gunbatar H, Arisoy A, Yildiz H (2016) Loeffler's syndrome: an interesting case report. Clin Respir J 10 (1):112-4. DOI:10.1111/crj.12173 PMID: 24931460
  4. Caulet T (1957) [Loffler syndrome and pulmonary eosinophilia.] Gaz Med Fr 64 (20):1737-8 passim. PMID: 13480465
  5. (1968) Löffler's syndrome. Br Med J 3 (5618):569-70. PMID: 5667987
  6. SASLAW MS, BOWMAN JA (1946) Loeffler's syndrome. J Fla Med Assoc 32 ():373. PMID: 21007279
  7. SPECTOR HI (1945) Loeffler's syndrome (transient pulmonary infiltrations with eosinophilia); report of a case and a review of the available literature. Dis Chest 11 ():380-91. PMID: 21025484
  8. GREIG ED (1945) On tropical eosinophilia associated with pulmonary signs (Loeffler's syndrome). J Trop Med Hyg 48 ():149-51. PMID: 21010826

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