Lupus nephritis causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Lupus nephritis}} | |||
{{CMG}}; {{AE}} [[User:Okamal|Omer Kamal, M.D.]][Mailto:okamal@bidmc.harvard.edu| <nowiki>[2]</nowiki>] | |||
== Overview == | == Overview == | ||
There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include [[genetic]]<nowiki/>predisposition, [[Auto-immune disease|auto-immune diseases]], and use of drugs. Less common factors include environmental factors and exposure to [[Ultraviolet light|ultraviolet (UV) light.]] | There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include [[genetic]]<nowiki/>predisposition, [[Auto-immune disease|auto-immune diseases]], and use of drugs. Less common factors include environmental factors and exposure to [[Ultraviolet light|ultraviolet (UV) light.]] | ||
== Causes == | ==Causes== | ||
* [[Genetic]] predisposition: | * [[Genetic]] predisposition:<ref name="pmid8749564">{{cite journal |vauthors=Schur PH |title=Genetics of systemic lupus erythematosus |journal=Lupus |volume=4 |issue=6 |pages=425–37 |year=1995 |pmid=8749564 |doi=10.1177/096120339500400603 |url=}}</ref> | ||
** [[HLA]] class [[polymorphism]] | ** [[HLA]] class [[polymorphism]] | ||
** [[Complement]] genes | ** [[Complement]] genes | ||
** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]] | ** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]] | ||
* [[Auto-immune]] disease | * [[Auto-immune]] disease<ref name="pmid7656468">{{cite journal |vauthors=Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT |title=Estrogens, the immune response and autoimmunity |journal=Clin. Exp. Rheumatol. |volume=13 |issue=2 |pages=217–26 |year=1995 |pmid=7656468 |doi= |url=}}</ref> | ||
* Infections | * Infections | ||
| Line 15: | Line 18: | ||
** [[Epstein-Barr virus|Epstein-Barr virus (EBV)]] | ** [[Epstein-Barr virus|Epstein-Barr virus (EBV)]] | ||
** [[Trypanosomiasis]] | ** [[Trypanosomiasis]] | ||
** [[Mycobacterial infection|Mycobacterial infections]] | ** [[Mycobacterial infection|Mycobacterial infections]] | ||
* Exposure to [[ultraviolet]] (UV) light | * Exposure to [[ultraviolet]] (UV) light<ref name="pmid12464374">{{cite journal |vauthors=Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS |title=Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history |journal=J Clin Epidemiol |volume=55 |issue=10 |pages=982–9 |year=2002 |pmid=12464374 |doi= |url=}}</ref> | ||
** Can exacerbate or induce systemic manifestations of | ** Can exacerbate or induce systemic manifestations of SLE | ||
* Drug-induced lupus | * Drug-induced lupus | ||
{{Columns-list|3| | |||
* [[Acebutolol]] | * [[Acebutolol]] | ||
* [[Adalimumab]] | * [[Adalimumab]] | ||
| Line 62: | Line 65: | ||
** [[Ticlopidine]] | ** [[Ticlopidine]] | ||
** [[Verapamil]] | ** [[Verapamil]] | ||
** [[Sulfonamide | ** [[Sulfonamide]]s | ||
}} | |||
==References== | ==References== | ||
Latest revision as of 17:58, 20 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include geneticpredisposition, auto-immune diseases, and use of drugs. Less common factors include environmental factors and exposure to ultraviolet (UV) light.
Causes
- Genetic predisposition:[1]
- HLA class polymorphism
- Complement genes
- Female sexual gene due to high levels of estrogen and prolactin
- Auto-immune disease[2]
- Exposure to ultraviolet (UV) light[3]
- Can exacerbate or induce systemic manifestations of SLE
- Drug-induced lupus
The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.
3References
- ↑ Schur PH (1995). "Genetics of systemic lupus erythematosus". Lupus. 4 (6): 425–37. doi:10.1177/096120339500400603. PMID 8749564.
- ↑ Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT (1995). "Estrogens, the immune response and autoimmunity". Clin. Exp. Rheumatol. 13 (2): 217–26. PMID 7656468.
- ↑ Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS (2002). "Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history". J Clin Epidemiol. 55 (10): 982–9. PMID 12464374.