SLC23A2: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Solute carrier family 23 member 2''' is a [[protein]] that in humans is encoded by the ''SLC23A2'' [[gene]].<ref name="pmid9804989">{{cite journal | vauthors = Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ | title = Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters | journal = Biochim Biophys Acta | volume = 1442 | issue = 2-3 | pages = 353–60 |date=Dec 1998 | pmid = 9804989 | pmc =  | doi =  10.1016/S0167-4781(98)00151-1}}</ref><ref name="pmid10331392">{{cite journal | vauthors = Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA | title = A family of mammalian Na+-dependent L-ascorbic acid transporters | journal = Nature | volume = 399 | issue = 6731 | pages = 70–5 |date=Jun 1999 | pmid = 10331392 | pmc =  | doi = 10.1038/19986 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9962| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 23 (nucleobase transporters), member 2
| HGNCid = 10973
| Symbol = SLC23A2
| AltSymbols =; KIAA0238; NBTL1; SLC23A1; SVCT2; YSPL2
| OMIM = 603791
| ECnumber =
| Homologene = 68440
| MGIid = 1859682
| GeneAtlas_image1 = PBB_GE_SLC23A2_209236_at_tn.png
  | GeneAtlas_image2 = PBB_GE_SLC23A2_209237_s_at_tn.png
  | GeneAtlas_image3 = PBB_GE_SLC23A2_211572_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0008520 |text = L-ascorbate:sodium symporter activity}} {{GNF_GO|id=GO:0008523 |text = sodium-dependent multivitamin transmembrane transporter activity}} {{GNF_GO|id=GO:0015205 |text = nucleobase transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0015851 |text = nucleobase transport}} {{GNF_GO|id=GO:0015993 |text = molecular hydrogen transport}} {{GNF_GO|id=GO:0019852 |text = L-ascorbic acid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9962
    | Hs_Ensembl = ENSG00000089057
    | Hs_RefseqProtein = NP_005107
    | Hs_RefseqmRNA = NM_005116
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 4781002
    | Hs_GenLoc_end = 4938939
    | Hs_Uniprot = Q9UGH3
    | Mm_EntrezGene = 54338
    | Mm_Ensembl = ENSMUSG00000027340
    | Mm_RefseqmRNA = NM_018824
    | Mm_RefseqProtein = NP_061294
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 131743937
    | Mm_GenLoc_end = 131836549
    | Mm_Uniprot = Q3TDU7
  }}
}}
'''Solute carrier family 23 (nucleobase transporters), member 2''', also known as '''SLC23A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9962| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.<ref name="entrez">{{cite web | title = Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9962| accessdate = }}</ref>
| summary_text = The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.<ref name="entrez">{{cite web | title = Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9962| accessdate = }}</ref>
}}
}}


Line 60: Line 12:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
Line 66: Line 18:
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Liang WJ, Johnson D, Jarvis SM |title=Vitamin C transport systems of mammalian cells. |journal=Mol. Membr. Biol. |volume=18 |issue= 1 |pages= 87-95 |year= 2001 |pmid= 11396616 |doi=  }}
*{{cite journal  | vauthors=Liang WJ, Johnson D, Jarvis SM |title=Vitamin C transport systems of mammalian cells. |journal=Mol. Membr. Biol. |volume=18 |issue= 1 |pages= 87–95 |year= 2001 |pmid= 11396616 |doi=10.1080/09687680110033774 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321-9, 341-54 |year= 1997 |pmid= 9039502 |doi= }}
*{{cite journal   |vauthors=Nagase T, Seki N, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=10.1093/dnares/3.5.321  }}
*{{cite journal  | author=Faaland CA, Race JE, Ricken G, ''et al.'' |title=Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters. |journal=Biochim. Biophys. Acta |volume=1442 |issue= 2-3 |pages= 353-60 |year= 1998 |pmid= 9804989 |doi=  }}
*{{cite journal  | vauthors=Hogue DL, Ling V |title=A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals. |journal=Genomics |volume=59 |issue= 1 |pages= 18–23 |year= 1999 |pmid= 10395795 |doi= 10.1006/geno.1999.5847 }}
*{{cite journal  | author=Tsukaguchi H, Tokui T, Mackenzie B, ''et al.'' |title=A family of mammalian Na+-dependent L-ascorbic acid transporters. |journal=Nature |volume=399 |issue= 6731 |pages= 70-5 |year= 1999 |pmid= 10331392 |doi= 10.1038/19986 }}
*{{cite journal   |vauthors=Rajan DP, Huang W, Dutta B, etal |title=Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 3 |pages= 762–8 |year= 1999 |pmid= 10471399 |doi= 10.1006/bbrc.1999.1272 }}
*{{cite journal  | author=Hogue DL, Ling V |title=A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals. |journal=Genomics |volume=59 |issue= 1 |pages= 18-23 |year= 1999 |pmid= 10395795 |doi= 10.1006/geno.1999.5847 }}
*{{cite journal   |vauthors=Daruwala R, Song J, Koh WS, etal |title=Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. |journal=FEBS Lett. |volume=460 |issue= 3 |pages= 480–4 |year= 1999 |pmid= 10556521 |doi=10.1016/S0014-5793(99)01393-9 }}
*{{cite journal | author=Rajan DP, Huang W, Dutta B, ''et al.'' |title=Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 3 |pages= 762-8 |year= 1999 |pmid= 10471399 |doi= 10.1006/bbrc.1999.1272 }}
*{{cite journal   |vauthors=Breton S, Wiederhold T, Marshansky V, etal |title=The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18219–24 |year= 2000 |pmid= 10748165 |doi= 10.1074/jbc.M909857199 }}
*{{cite journal | author=Daruwala R, Song J, Koh WS, ''et al.'' |title=Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. |journal=FEBS Lett. |volume=460 |issue= 3 |pages= 480-4 |year= 1999 |pmid= 10556521 |doi=  }}
*{{cite journal   |vauthors=Holliday LS, Lu M, Lee BS, etal |title=The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32331–7 |year= 2000 |pmid= 10915794 |doi= 10.1074/jbc.M004795200 }}
*{{cite journal | author=Breton S, Wiederhold T, Marshansky V, ''et al.'' |title=The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18219-24 |year= 2000 |pmid= 10748165 |doi= 10.1074/jbc.M909857199 }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Holliday LS, Lu M, Lee BS, ''et al.'' |title=The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32331-7 |year= 2000 |pmid= 10915794 |doi= 10.1074/jbc.M004795200 }}
*{{cite journal  | author=Hediger MA |title=New view at C. |journal=Nat. Med. |volume=8 |issue= 5 |pages= 445–6 |year= 2002 |pmid= 11984580 |doi= 10.1038/nm0502-445 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Hediger MA |title=New view at C. |journal=Nat. Med. |volume=8 |issue= 5 |pages= 445-6 |year= 2002 |pmid= 11984580 |doi= 10.1038/nm0502-445 }}
*{{cite journal  | vauthors=Fischer H, Schwarzer C, Illek B |title=Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 10 |pages= 3691–6 |year= 2004 |pmid= 14993613 |doi= 10.1073/pnas.0308393100 | pmc=373524 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Lutsenko EA, Carcamo JM, Golde DW |title=A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3150–6 |year= 2004 |pmid= 15060139 |doi=10.1128/MCB.24.8.3150-3156.2004  | pmc=381605 }}
*{{cite journal  | author=Fischer H, Schwarzer C, Illek B |title=Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 10 |pages= 3691-6 |year= 2004 |pmid= 14993613 |doi= 10.1073/pnas.0308393100 }}
*{{cite journal   |vauthors=Seno T, Inoue N, Matsui K, etal |title=Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells. |journal=J. Vasc. Res. |volume=41 |issue= 4 |pages= 345–51 |year= 2004 |pmid= 15340249 |doi= 10.1159/000080525 }}
*{{cite journal  | author=Lutsenko EA, Carcamo JM, Golde DW |title=A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3150-6 |year= 2004 |pmid= 15060139 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Seno T, Inoue N, Matsui K, ''et al.'' |title=Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells. |journal=J. Vasc. Res. |volume=41 |issue= 4 |pages= 345-51 |year= 2004 |pmid= 15340249 |doi= 10.1159/000080525 }}
*{{cite journal  | vauthors=McNulty AL, Vail TP, Kraus VB |title=Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. |journal=Biochim. Biophys. Acta |volume=1712 |issue= 2 |pages= 212–21 |year= 2005 |pmid= 15921655 |doi= 10.1016/j.bbamem.2005.04.009 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=McNulty AL, Vail TP, Kraus VB |title=Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. |journal=Biochim. Biophys. Acta |volume=1712 |issue= 2 |pages= 212-21 |year= 2005 |pmid= 15921655 |doi= 10.1016/j.bbamem.2005.04.009 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 06:28, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.[1][2][3]

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.[3]

See also

References

  1. ↑ Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (Dec 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochim Biophys Acta. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.
  2. ↑ Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (Jun 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. doi:10.1038/19986. PMID 10331392.
  3. ↑ 3.0 3.1 "Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=SLC23A2&oldid=1419522"