Ureaplasma urealyticum prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fatimo Biobaku M.B.B.S [2]


There are no guidelines for the prevention of Ureaplasma colonization or infection.


There are no guidelines for the prevention of Ureaplasma colonization or infection. There is controversial benefit for screening of pregnant women for urogenital colonization with Ureaplasma species.[1] A reduction in adverse pregnancy outcomes has been documented in some studies following medical intervention before delivery in pregnant women with Ureaplasma colonization of the genital tract. Some of the studies demonstrated the following findings:

  • A lower rate of preterm birth and improved neonatal outcomes in pregnant women who received antibiotics in late pregnancy for the treatment of genital Mycoplasma hominis and/or Ureaplasma species colonization.[1]
  • Prolonged vaginal progesterone administration in selected pregnant women with risk factors for preterm birth reduced cervicovaginal colonization by U. urealyticum.[2]


  1. 1.0 1.1 Vouga M, Greub G, Prod'hom G, Durussel C, Roth-Kleiner M, Vasilevsky S; et al. (2014). "Treatment of genital mycoplasma in colonized pregnant women in late pregnancy is associated with a lower rate of premature labour and neonatal complications". Clin Microbiol Infect. 20 (10): 1074–9. doi:10.1111/1469-0691.12686. PMID 24849820.
  2. Koucký M, Malíčková K, Cindrová-Davies T, Smíšek J, Vráblíková H, Černý A; et al. (2016). "Prolonged progesterone administration is associated with less frequent cervicovaginal colonization by Ureaplasma urealyticum during pregnancy - Results of a pilot study". J Reprod Immunol. 116: 35–41. doi:10.1016/j.jri.2016.04.285. PMID 27172838.

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