Tromantadine

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Tromantadine
Skeletal formula
Ball-and-stick model
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Topical
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
NIAID ChemDB
E number{{#property:P628}}
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Chemical and physical data
FormulaC16H28N2O2
Molar mass280.406 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade name Viru-Merz. Its performance is similar to aciclovir.

Like rimantadine and amantadine, tromantadine is a derivative of adamantane.

Mechanism

Tromantadine inhibits the early and late events in the virus replication cycle.[1] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

References

  1. Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6. doi:10.1128/aac.22.6.1031. PMC 185716. PMID 6297383.

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