Sudden cardiac versus non-cardiac death

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Edzel Lorraine Co, DMD, MD[3] Nehal Eid, M.D.[4]

Overview

Studies of Sudden Cardiac Death in Young Adults
Source Setting Study years Study type Age range, y Data source No.of individuals Autopsy rate, % Toxicology Incidence/100000 patient-years Cardiac cause, % SADSor SUD,% Witnessed, % During sleep,% During exercise, %
Out-of-hospital cardiac arrest
Kitamuraetal,[5] 2010 Japan (Osaka) 1998-2007 Prospective 13-49 EMS records 2220 0 3.8 22-32.1
Meyer et al,[9] 2012 US (King County) 1980-2009 Retrospective 25-35 EMS and medical records, death certificates, autopsy reports 361 72.9 Overdoses excluded 4.4 19.4 66.7 24.5
Paratz et al,[21] 2022 Australia (Victoria) 2019-2021 Prospective 36-49 Medical records, autopsy reports 754 67.5 Yes,positive in 17.1% (for ages 1-50y) 30.2 55 10.9 28 41.2 9
Empana et al,[22]2022 Europe 2012-2017 Retrospective 18-39 Registry data 0 14.4 (Men), 9.5 (Women)
Range 3.8-30.2 55 10.9-19.4 28-66.7 41.2 9-24.5
Presumed sudden cardiac death
Hua et al,[23]2009 China (4 regions) 2005-2006 Retrospective 25-34 Nationaldata,medical records,death certificates,autopsy reports 284 Rare 7.8
Hendrix et al,[24]2010 The Netherlands (12 provinces) 1996-2006 Retrospective 30-39 Death certificates, forensic database 1458 0 5.5(Men),2.4 (Women)
Margey et al,[25]2011 Ireland 2005-2007 Retrospective 15-35 National data, autopsy reports 292 70.5 Yes,positive in 21.1% 2.9 64 26.7 7.8
van der Werf et al[26],2016 The Netherlands (4 regions) 2008-2011 Retrospective 1-44;Median, 38 (IQR,29-42) EMS records, autopsy reports, general practitioners 390 43 Rarely, atcoroner’s discretion 4.6 70 13.6 33 8
Bonny et al,[8] 2017 Cameroon (Douala) 2013 Retrospective 18-39 EMS and medical records Rare 11.9 (Age range,18-29y) 42(Age range, 30-39y)
Tseng et al,[15] 2018 US (San Francisco) 2011-2014 Prospective 18-39 EMS and medical records, forensic and autopsy reports 32 97 Yes,positivein 18.8% 4.2 59 9 22 50 6
Zhang et al,[10] 2019 China (Xinjiang) 2015 Retrospective 18-35 Medical records, patient interview Rare 4.2
Empana et al,[22] 2022 Europe 2012-2017 Retrospective 18-39 Registry data 0 6.7(Men)4.3 (Women)
Carrington et al,[27]2023 Portugal (9 districts) 2012-2016 Retrospective 1-40 Mean (SD):32 (7). Medical records, forensic database 159 100 Yes,none positive 2.4 58 32.1 17.5 15
Range (except Bonny et al [8]) 2.4-7.8 40.7-67 9-32.1 22 17.5-50 6-15
Sudden cardiac death
Winkel

et al,[28]2011

Denmark 2000-2006 Retrospective 1-35 Median (IQR),28 (21-33) EMS and medical records, death certificates,autopsy reports, police reports 469 75 Done in 23.9% of SUDs, none positive 1.9 29 45 34 11
Bagnall et al,[29] 2016 Australia and New Zealand 2010-2012 Prospective 21-35 Medical records, death certificates, autopsy reports 490 100 Yes 1.1-3.2 40 38 15
Wisten et al,[30]2017 Sweden 2000-2010 Retrospective 18-35 National data, medical records, death certificate 552 95 Positive toxicology cases excluded 1.2-5.8 (Men), 0.5-2.2 (women) 31 40 38 14
Tseng et al,[15]2018 US (San Francisco County) 2011-2014 Prospective 18-39 EMS and medical records, forensic and autopsy reports 19 97 Yes,none positive 2.4 18 37 39 21
Ha et al,[31] 2020 Australia 2000-2016 Retrospective 1-35 Mean (SD):28 (7) Registry data, medical records, autopsy reports 2006 95 Done in 97%, positive toxicology cases excluded 0.9-1.5 14 38 7
Rücklová et al,[32]2022 Czech Republic(5 regions) 2014-2019 Retrospective 21-40 Medical records, autopsy and police reports 232 93 Done in 51% 3.4 11.8 27 38 7
Lynge et al,[33] 2023 Denmark 2002-2009 Retrospective 21-40 Registry data, medical records, death certificates, autopsy reports 620 55 2.7(Age,21-25y) 4.4(Age,26-30y) 6.5(Age,31-35y) 10.7(Age,36-40y) 42 32 9
Range 0.5-10.7 11.8-40 27-45 32-39 7-21

References

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