Restless legs syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

References

  1. Bogan RK, Cheray JA (2013). "Restless legs syndrome: a review of diagnosis and management in primary care". Postgrad Med. 125 (3): 99–111. doi:10.3810/pgm.2013.05.2636. PMID 23748511.
  2. Karroum EG, Golmard JL, Leu-Semenescu S, Arnulf I (2015). "Painful restless legs syndrome: a severe, burning form of the disease". Clin J Pain. 31 (5): 459–66. doi:10.1097/AJP.0000000000000133. PMID 25167326.
  3. 3.0 3.1 Rulong G, Dye T, Simakajornboon N (2018). "Pharmacological Management of Restless Legs Syndrome and Periodic Limb Movement Disorder in Children". Paediatr Drugs. 20 (1): 9–17. doi:10.1007/s40272-017-0262-0. PMID 28831753.
  4. 4.0 4.1 Facheris MF, Hicks AA, Pramstaller PP, Pichler I (2010). "Update on the management of restless legs syndrome: existing and emerging treatment options". Nat Sci Sleep. 2: 199–212. doi:10.2147/NSS.S6946. PMC 3630948. PMID 23616710.
  5. Li Y, Wang W, Winkelman JW, Malhotra A, Ma J, Gao X (2013). "Prospective study of restless legs syndrome and mortality among men". Neurology. 81 (1): 52–9. doi:10.1212/WNL.0b013e318297eee0. PMC 3770202. PMID 23761622.
  6. Li Y, Li Y, Winkelman JW, Walters AS, Han J, Hu FB; et al. (2018). "Prospective study of restless legs syndrome and total and cardiovascular mortality among women". Neurology. 90 (2): e135–e141. doi:10.1212/WNL.0000000000004814. PMC 5772151. PMID 29247069.
  7. Baiardi S, Mondini S, Baldi Antognini A, Santoro A, Cirignotta F (2017). "Survival of Dialysis Patients with Restless Legs Syndrome: A 15-Year Follow-Up Study". Am J Nephrol. 46 (3): 224–230. doi:10.1159/000479938. PMID 28869939.

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