Restless legs syndrome medical therapy

Jump to navigation Jump to search

Restless legs syndrome Microchapters


Patient Information


Historical Perspective




Differentiating Restless legs syndrome from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings



Echocardiography and Ultrasound

CT scan


Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Restless legs syndrome medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Restless legs syndrome medical therapy

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Restless legs syndrome medical therapy

CDC on Restless legs syndrome medical therapy

Restless legs syndrome medical therapy in the news

Blogs on Restless legs syndrome medical therapy

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Restless legs syndrome medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Medical Therapy


Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].

Medical Therapy

In patients with mild symptoms of restless legs syndrome, no treatment may be required, although all patients should be screened for iron deficiency.[1]

  • Pharmacologic medical therapy is recommended among patients with persistent or moderate to severe symptoms of restless legs syndrome.[1]
  • Pharmacologic medical therapies for restless legs syndrome include dopamine agonists, alpha-2-delta calcium channel ligands and opioids.[1]
  • The treatment of restless legs syndrome must be individualized to each patient.[1]
  • In patients with mild symptoms, no treatment is required.[1]

Treatment of restless legs syndrome

  • Preferred regimen (1): pramipexole[2]
    • Treatment with pramipexole is started at a dosage of 0.25 mg per day, and progressively increase until the optimal therapeutic effect is obtained.
  • Preferred regimen (2): Ropinirole[3]
    • It is important to take ropinirole prior to symptom onset.
    • For daily RLS, ropinirole may be started at 0.25 mg per day at 2 hours before RLS symptom onset, and then increased by 0.25 mg every 2 to 3 days until symptom relief is achieved (Silber et al 2004). Starting dose should be individualized based on RLS severity and age.
    • The effective dose for ropinirole is typically 2 mg or less.
    • Some patients may require doses as high as 6 mg/day.
  • Preferred regimen (3): Carbidopa/levodopa 25/100 mg PO daily at bedtime[1]
  • Alternative regimen (1): Gabapentin 300–1200 mg daily about 1 h before bedtime.[1]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Comella CL (2014). "Treatment of restless legs syndrome". Neurotherapeutics. 11 (1): 177–87. doi:10.1007/s13311-013-0247-9. PMC 3899490. PMID 24363103.
  2. Montplaisir J, Denesle R, Petit D (2000). "Pramipexole in the treatment of restless legs syndrome: a follow-up study". Eur J Neurol. 7 Suppl 1: 27–31. PMID 11054156.
  3. Kushida CA (2006). "Ropinirole for the treatment of restless legs syndrome". Neuropsychiatr Dis Treat. 2 (4): 407–19. PMC 2671939. PMID 19412490.

Template:WH Template:WS