Pulmonary hypertension laboratory tests

Jump to navigation Jump to search

Pulmonary Hypertension Microchapters


Patient Information


Historical Perspective




Differentiating Pulmonary hypertension from other Diseases

Epidemiology & Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Study of Choice

History & Symptoms

Physical Examination

Laboratory Findings


Chest X Ray



Echocardiography or Ultrasound

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Pulmonary hypertension laboratory tests On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Google Images

American Roentgen Ray Society Images of Pulmonary hypertension laboratory tests

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Pulmonary hypertension laboratory tests

CDC on Pulmonary hypertension laboratory tests

Pulmonary hypertension laboratory tests in the news

Blogs on Pulmonary hypertension laboratory tests

Directions to Hospitals Treating Pulmonary hypertension

Risk calculators and risk factors for Pulmonary hypertension laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-in-Chief: Ralph Matar; José Eduardo Riceto Loyola Junior, M.D.[2]


There are no specific diagnostic lab findings associated with pulmonary hypertension. Despite that, several laboratory tests are required in the evaluation of a patient for pulmonary hypertension to assess its severity or possible associated causes. Biochemistry, hematology and thyroid function tests are required in all patients with pulmonary hypertension. They are important for the diagnosis of chronic hemolytic anemia, myeloproliferative disorders, thyroid disorders and chronic renal failure on dialysis.

Laboratory Findings

Other Biomarkers

Brain natriuretic peptide (BNP) and N-terminal fragment of BNP (NT-proBNP)

  • BNP levels correlate with hemodynamic parameters, exercise capacity, and NYHA functional class and bear prognostic significance in IPAH, in pulmonary hypertension due to lung diseases, and in chronic thromboembolic pulmonary hypertension.[1][2][3][4]
  • N-terminal fragment of BNP (NT-proBNP) has been studied as an alternative biomarker to BNP in various classes of pulmonary hypertension.
  • Higher NT-proBNP and peak oxygen uptake were shown to be independent predictors of mortality and a supramedian NT-proBNP level indicated a significantly lower survival.[5][6]

Cyclic guanosine monophosphate (cGMP)

  • Cyclic guanosine monophosphate (cGMP) is produced by the activation of guanylate cyclase and can be viewed as an indirect marker of nitric oxide production.
  • Plasma cGMP levels are higher in patients with pulmonary hypertension and decrease after inhalation of iloprost.[7]
  • A significant correlation between baseline plasma cGMP and severity of pulmonary arterial hypertension has also been reported.
  • Nitric oxide inhalation provoked a prompt increase in cGMP production, however, the magnitude of cGMP release is not linked with a decrease in pulmonary vascular resistance.[8]


  • D-dimer is a degradation product of cross-linked fibrin and may represent microvascular thrombosis which is implicated in the pathogenesis of pulmonary hypertension.
  • D-dimer has been shown to be increased and correlates with disease severity as measured by NYHA class, resting oxygen saturation, and mean pulmonary artery pressure.
  • There was also an inverse correlation between d-dimer levels and one-year survival in patients with primary pulmonary hypertension.[9][10]


  1. Nagaya, N.; Nishikimi, T.; Uematsu, M.; Satoh, T.; Kyotani, S.; Sakamaki, F.; Kakishita, M.; Fukushima, K.; Okano, Y. (2000). "Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension". Circulation. 102 (8): 865–70. PMID 10952954. Unknown parameter |month= ignored (help)
  2. Kucher, N.; Printzen, G.; Goldhaber, SZ. (2003). "Prognostic role of brain natriuretic peptide in acute pulmonary embolism". Circulation. 107 (20): 2545–7. doi:10.1161/01.CIR.0000074039.45523.BE. PMID 12742987. Unknown parameter |month= ignored (help)
  3. ten Wolde, M.; Tulevski, II.; Mulder, JW.; Söhne, M.; Boomsma, F.; Mulder, BJ.; Büller, HR. (2003). "Brain natriuretic peptide as a predictor of adverse outcome in patients with pulmonary embolism". Circulation. 107 (16): 2082–4. doi:10.1161/01.CIR.0000070020.79932.DB. PMID 12707233. Unknown parameter |month= ignored (help)
  4. Leuchte, HH.; Baumgartner, RA.; Nounou, ME.; Vogeser, M.; Neurohr, C.; Trautnitz, M.; Behr, J. (2006). "Brain natriuretic peptide is a prognostic parameter in chronic lung disease". Am J Respir Crit Care Med. 173 (7): 744–50. doi:10.1164/rccm.200510-1545OC. PMID 16415273. Unknown parameter |month= ignored (help)
  5. Andreassen, AK.; Wergeland, R.; Simonsen, S.; Geiran, O.; Guevara, C.; Ueland, T. (2006). "N-terminal pro-B-type natriuretic peptide as an indicator of disease severity in a heterogeneous group of patients with chronic precapillary pulmonary hypertension". Am J Cardiol. 98 (4): 525–9. doi:10.1016/j.amjcard.2006.02.061. PMID 16893710. Unknown parameter |month= ignored (help)
  6. Fijalkowska, A.; Kurzyna, M.; Torbicki, A.; Szewczyk, G.; Florczyk, M.; Pruszczyk, P.; Szturmowicz, M. (2006). "Serum N-terminal brain natriuretic peptide as a prognostic parameter in patients with pulmonary hypertension". Chest. 129 (5): 1313–21. doi:10.1378/chest.129.5.1313. PMID 16685024. Unknown parameter |month= ignored (help)
  7. Wiedemann, R.; Ghofrani, HA.; Weissmann, N.; Schermuly, R.; Quanz, K.; Grimminger, F.; Seeger, W.; Olschewski, H. (2001). "Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation". J Am Coll Cardiol. 38 (4): 1130–6. PMID 11583893. Unknown parameter |month= ignored (help)
  8. Ghofrani, HA.; Wiedemann, R.; Rose, F.; Weissmann, N.; Schermuly, RT.; Quanz, K.; Grimminger, F.; Seeger, W.; Olschewski, H. (2002). "Lung cGMP release subsequent to NO inhalation in pulmonary hypertension: responders versus nonresponders". Eur Respir J. 19 (4): 664–71. PMID 11998996. Unknown parameter |month= ignored (help)
  9. Shitrit, D.; Bendayan, D.; Rudensky, B.; Izbicki, G.; Huerta, M.; Fink, G.; Kramer, MR. (2002). "Elevation of ELISA d-dimer levels in patients with primary pulmonary hypertension". Respiration. 69 (4): 327–9. doi:63270 Check |doi= value (help). PMID 12169745.
  10. Shitrit, D.; Bendayan, D.; Bar-Gil-Shitrit, A.; Huerta, M.; Rudensky, B.; Fink, G.; Kramer, MR. (2002). "Significance of a plasma D-dimer test in patients with primary pulmonary hypertension". Chest. 122 (5): 1674–8. PMID 12426270. Unknown parameter |month= ignored (help)