Pulmonary hypertension epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ralph Matar; José Eduardo Riceto Loyola Junior, M.D.[2]

Overview

Pulmonary arterial hypertension has been considered as a disease of young women. The mean age of patients in the U.S. registry was 36 years and the overall female-to-male ratio was 1.7:1.

Epidemiology and Demographics

Incidence

  • While previously considered a rare disease, the most recent evidence from a French registry suggests that the incidence of new cases of pulmonary arterial hypertension is 0.20-0.30 cases per 100,000 individuals.[1]

Prevalence

  • The prevalence of pulmonary hypertension is approximately 1.5-5 per 100,000 individuals.[2]

Age

  • Pulmonary hypertension usually develops between the ages of 20 and 60, but it can occur at any age. The mean age of patients in the U.S. registry was approximately 36 years old.[1]

Gender

  • The female-to-male ratio for PH is approximately 1.7:1.[1]
  • Idiopathic pulmonary hypertension (IPAH), which is more prevalent in women (3x more common), was considered the most common type of pulmonary arterial hypertension in a French registry. Usually it affects women between 30-60 years old.[2]
  • Males often face a worse prognosis.[2]

References

  1. 1.0 1.1 1.2 Rich, S.; Dantzker, DR.; Ayres, SM.; Bergofsky, EH.; Brundage, BH.; Detre, KM.; Fishman, AP.; Goldring, RM.; Groves, BM. (1987). "Primary pulmonary hypertension. A national prospective study". Ann Intern Med. 107 (2): 216–23. PMID 3605900. Unknown parameter |month= ignored (help)
  2. 2.0 2.1 2.2 Levine DJ (2021). "Pulmonary arterial hypertension: updates in epidemiology and evaluation of patients". Am J Manag Care. 27 (3 Suppl): S35–S41. doi:10.37765/ajmc.2021.88609. PMID 33710842 Check |pmid= value (help).