Potassium-sparing diuretic

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Potassium-sparing diuretic refers to diuretic drugs that do not promote the secretion of potassium into the urine. They are used as adjunctive therapy, together with other drugs, in the treatment of hypertension and management of congestive heart failure.

Mechanism of action

Potassium-sparing diuretics decrease sodium reabsorption at collecting tubules, inducing diuresis; decrease activity of aldosterone at collecting tubules.

Indications

Potassium-sparing diuretics are generally used in combination with other diuretic drugs (e.g. loop diuretics) that would otherwise tend to lower the potassium levels to potentially dangerous low levels (hypokalemia). The combination therefore helps maintain a normal reference range for potassium.

Side effects

On their own this group of drugs may raise potassium levels beyond the normal range, termed hyperkalemia, which risks potentially fatal arrhythmias.

Chemical structure

Potassium-sparing diuretics do not share any obvious chemical similarities, except for the steroid-structure of the aldosterone antagonists. Those in clinical use include:

See also

External links

References

  • Block JH, Beale JM. "Organic Medicinal and Pharmaceutical Chemistry" 11th edition. Lippincott Williams & Wilkins. 2004.


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| group5 = Clinical Trials Involving Potassium-sparing diuretic | list5 = Ongoing Trials on Potassium-sparing diuretic at Clinical Trials.govTrial results on Potassium-sparing diureticClinical Trials on Potassium-sparing diuretic at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Potassium-sparing diuretic | list6 = US National Guidelines Clearinghouse on Potassium-sparing diureticNICE Guidance on Potassium-sparing diureticNHS PRODIGY GuidanceFDA on Potassium-sparing diureticCDC on Potassium-sparing diuretic


| group7 = Textbook Information on Potassium-sparing diuretic | list7 = Books and Textbook Information on Potassium-sparing diuretic


| group8 = Pharmacology Resources on Potassium-sparing diuretic | list8 = AND (Dose)}} Dosing of Potassium-sparing diureticAND (drug interactions)}} Drug interactions with Potassium-sparing diureticAND (side effects)}} Side effects of Potassium-sparing diureticAND (Allergy)}} Allergic reactions to Potassium-sparing diureticAND (overdose)}} Overdose information on Potassium-sparing diureticAND (carcinogenicity)}} Carcinogenicity information on Potassium-sparing diureticAND (pregnancy)}} Potassium-sparing diuretic in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Potassium-sparing diuretic


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Potassium-sparing diuretic | list9 = AND (pharmacogenomics)}} Genetics of Potassium-sparing diureticAND (pharmacogenomics)}} Pharmacogenomics of Potassium-sparing diureticAND (proteomics)}} Proteomics of Potassium-sparing diuretic


| group10 = Newstories on Potassium-sparing diuretic | list10 = Potassium-sparing diuretic in the newsBe alerted to news on Potassium-sparing diureticNews trends on Potassium-sparing diuretic


| group11 = Commentary on Potassium-sparing diuretic | list11 = Blogs on Potassium-sparing diuretic

| group12 = Patient Resources on Potassium-sparing diuretic | list12 = Patient resources on Potassium-sparing diureticDiscussion groups on Potassium-sparing diureticPatient Handouts on Potassium-sparing diureticDirections to Hospitals Treating Potassium-sparing diureticRisk calculators and risk factors for Potassium-sparing diuretic


| group13 = Healthcare Provider Resources on Potassium-sparing diuretic | list13 = Symptoms of Potassium-sparing diureticCauses & Risk Factors for Potassium-sparing diureticDiagnostic studies for Potassium-sparing diureticTreatment of Potassium-sparing diuretic

| group14 = Continuing Medical Education (CME) Programs on Potassium-sparing diuretic | list14 = CME Programs on Potassium-sparing diuretic

| group15 = International Resources on Potassium-sparing diuretic | list15 = Potassium-sparing diuretic en EspanolPotassium-sparing diuretic en Francais

| group16 = Business Resources on Potassium-sparing diuretic | list16 = Potassium-sparing diuretic in the MarketplacePatents on Potassium-sparing diuretic

| group17 = Informatics Resources on Potassium-sparing diuretic | list17 = List of terms related to Potassium-sparing diuretic


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