PMM1

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.[1][2][3]

Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins.[3]

This enzyme has been extracted from the venom of the wasp species Polistes major major.[4]

References

  1. Matthijs G, Schollen E, Pirard M, Budarf ML, Van Schaftingen E, Cassiman JJ (Jun 1997). "PMM (PMM1), the human homologue of SEC53 or yeast phosphomannomutase, is localized on chromosome 22q13". Genomics. 40 (1): 41–7. doi:10.1006/geno.1996.4536. PMID 9070917.
  2. Pirard M, Collet JF, Matthijs G, Van Schaftingen E (Sep 1997). "Comparison of PMM1 with the phosphomannomutases expressed in rat liver and in human cells". FEBS Lett. 411 (2–3): 251–4. doi:10.1016/S0014-5793(97)00704-7. PMID 9271215.
  3. 3.0 3.1 "Entrez Gene: PMM1 phosphomannomutase 1".
  4. ČeŘovský V (2007). "Identification of three novel peptides isolated from the venom of the neotropical social wasp Polistes major major". Journal of Peptide Science. 13: 445–450. doi:10.1002/psc.860.

Further reading



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