Phosphoenolpyruvate mutase

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In enzymology, a phosphoenolpyruvate mutase (EC is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate 3-phosphonopyruvate

Hence, this enzyme has one substrate, phosphoenolpyruvate, and one product, 3-phosphonopyruvate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is phosphoenolpyruvate 2,3-phosphonomutase. Other names in common use include phosphoenolpyruvate-phosphonopyruvate phosphomutase, PEP phosphomutase, phosphoenolpyruvate phosphomutase, PEPPM, and PEP phosphomutase. This enzyme participates in aminophosphonate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1M1B, 1PYM, 1S2T, 1S2U, 1S2V, and 1S2W.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Bowman E, McQueney M, Barry RJ and Dunaway-Mariano D (1988). "Catalysis and thermodynamics of the phosphoenolpyruvate phosphonopyruvate rearrangement - entry into the phosphonate class of naturally-occurring organo-phosphorus compounds". J. Am. Chem. Soc. 110: 5575&ndash, 5576.
  • Hidaka T, Imai S, Hara O, Anzai H, Murakami T, Nagaoka K, Seto H (1990). "Carboxyphosphonoenolpyruvate phosphonomutase, a novel enzyme catalyzing C-P bond formation". J. Bacteriol. 172: 3066&ndash, 72. PMID 2160937.
  • Seidel HM, Freeman S, Seto H, Knowles JR (1988). "Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon-phosphorus bond". Nature. 335: 457&ndash, 8. PMID 3138545.

External links

The CAS registry number for this enzyme class is 115756-49-5.

Gene Ontology (GO) codes