Phosphomannomutase

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In enzymology, a phosphomannomutase (EC 5.4.2.8) is an enzyme that catalyzes the chemical reaction

alpha-D-mannose 1-phosphate D-mannose 6-phosphate

Hence, this enzyme has one substrate, alpha-D-mannose 1-phosphate, and one product, D-mannose 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-mannose 1,6-phosphomutase. Other names in common use include mannose phosphomutase, phosphomannose mutase, and D-mannose 1,6-phosphomutase. This enzyme participates in fructose and mannose metabolism. It has 2 cofactors: D-glucose 1,6-bisphosphate, and D-Mannose 1,6-bisphosphate.

Structural studies

As of late 2007, 18 structures have been solved for this class of enzymes, with PDB accession codes 1K2Y, 1K35, 1P5D, 1P5G, 1PCJ, 1PCM, 1WQA, 2AMY, 2F7L, 2FKF, 2FKM, 2FUC, 2FUE, 2H4L, 2H5A, 2I54, 2I55, and 2Q4R.

References

  • IUBMB entry for 5.4.2.8
  • BRENDA references for 5.4.2.8 (Recommended.)
  • PubMed references for 5.4.2.8
  • PubMed Central references for 5.4.2.8
  • Google Scholar references for 5.4.2.8
  • Small DM and Matheson NK (1979). "Phosphomannomutase and phosphoglucomutase in developing Cassia corymbosa seeds". Phytochemistry. 18: 1147&ndash, 1150.

External links

The CAS registry number for this enzyme class is 59536-73-1.

Gene Ontology (GO) codes


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