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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Profilin-2 is a protein that in humans is encoded by the PFN2 gene.[1][2][3]

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.[3]


PFN2 has been shown to interact with ROCK1,[4] Vasodilator-stimulated phosphoprotein,[5][6] CCDC113[7] and FMNL1.[8]


  1. Joensuu T, Blanco G, Pakarinen L, Sistonen P, Kaariainen H, Brown S, Chapelle A, Sankila EM (March 1997). "Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region". Genomics. 38 (3): 255–63. doi:10.1006/geno.1996.0626. PMID 8975700.
  2. Honore B, Madsen P, Andersen AH, Leffers H (October 1993). "Cloning and expression of a novel human profilin variant, profilin II". FEBS Lett. 330 (2): 151–5. doi:10.1016/0014-5793(93)80262-S. PMID 8365484.
  3. 3.0 3.1 "Entrez Gene: PFN2 profilin 2".
  4. Da Silva, Jorge Santos; Medina Miguel; Zuliani Cecilia; Di Nardo Alessia; Witke Walter; Dotti Carlos G (September 2003). "RhoA/ROCK regulation of neuritogenesis via profilin IIa–mediated control of actin stability". J. Cell Biol. United States. 162 (7): 1267–79. doi:10.1083/jcb.200304021. ISSN 0021-9525. PMC 2173969. PMID 14517206.
  5. Reinhard, M; Giehl K; Abel K; Haffner C; Jarchau T; Hoppe V; Jockusch B M; Walter U (April 1995). "The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins". EMBO J. ENGLAND. 14 (8): 1583–9. ISSN 0261-4189. PMC 398250. PMID 7737110.
  6. Harbeck, B; Hüttelmaier S; Schluter K; Jockusch B M; Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. UNITED STATES. 275 (40): 30817–25. doi:10.1074/jbc.M005066200. ISSN 0021-9258. PMID 10882740.
  7. "Coiled-Coil Domain Containing 113". GeneCards. Retrieved 5/8/2013. Check date values in: |accessdate= (help)
  8. Yayoshi-Yamamoto, S; Taniuchi I; Watanabe T (September 2000). "FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages". Mol. Cell. Biol. UNITED STATES. 20 (18): 6872–81. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN 0270-7306. PMC 86228. PMID 10958683.

Further reading