Necrotizing fasciitis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]

Overview

Common risk factors in the development of necrotizing fasciitis include trauma, alcoholism, diabetes, intravenous drug abuse, immunosupression and burns.[1]

Risk Factors

Common risk factors in the development of necrotizing fasciitis include:[1][2][3][4][5][6]

Type 1 Type 2 Type 3 Type 4
Alcoholism
• Antecedent trauma
Carcinoma
Cardiopulmonay disease
Diabetes
Iatrogenic procedures
Immunosupression (e.g., HIV and corticosteroid use)
Intravenous drug abuse
• Male gender
Peripheral vascular disease
• Recent surgery
Smoking
• Advanced age
Alcoholism
• Antecedent trauma
Carcinoma
Cardiopulmonay disease
Diabetes
Immunosupression (e.g., HIV and corticosteroid use)
Intravenous drug abuse
• Male gender
Peripheral vascular disease
• Recent surgery
• Exposure to children with sore throat
HLA class II haplotype
• Lack of specific anti-GAS antibodies
Varicella infection
• Advanced age
• Raw oyster ingestion
• Wound contamination with sea water
Immunosupression
• Advanced age
Immunosupression
• Antecedent trauma
Burns
• Advanced age

Role of NSAIDS in GASNF

References

  1. 1.0 1.1 1.2 Misiakos EP, Bagias G, Patapis P, Sotiropoulos D, Kanavidis P, Machairas A (2014). "Current concepts in the management of necrotizing fasciitis". Front Surg. 1: 36. doi:10.3389/fsurg.2014.00036. PMC 4286984. PMID 25593960.
  2. Chen JL, Fullerton KE, Flynn NM (2001). "Necrotizing fasciitis associated with injection drug use". Clin Infect Dis. 33 (1): 6–15. doi:10.1086/320874. PMID 11389488.
  3. Elliott DC, Kufera JA, Myers RA (1996). "Necrotizing soft tissue infections. Risk factors for mortality and strategies for management". Ann Surg. 224 (5): 672–83. PMC 1235444. PMID 8916882.
  4. McHenry CR, Piotrowski JJ, Petrinic D, Malangoni MA (1995). "Determinants of mortality for necrotizing soft-tissue infections". Ann Surg. 221 (5): 558–63, discussion 563-5. PMC 1234638. PMID 7748037.
  5. Francis KR, Lamaute HR, Davis JM, Pizzi WF (1993). "Implications of risk factors in necrotizing fasciitis". Am Surg. 59 (5): 304–8. PMID 8489099.
  6. Goh T, Goh LG, Ang CH, Wong CH (2014). "Early diagnosis of necrotizing fasciitis". Br J Surg. 101 (1): e119–25. doi:10.1002/bjs.9371. PMID 24338771.
  7. Holder EP, Moore PT, Browne BA (1997). "Nonsteroidal anti-inflammatory drugs and necrotising fasciitis. An update". Drug Saf. 17 (6): 369–73. PMID 9429836.
  8. NSAIDS and NF http://www.medsafe.govt.nz/Profs/puarticles/necf.htm (2000) Accessed on September 11, 2016

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