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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Methisazone (USAN) or metisazone (INN) is an antiviral drug that works by inhibiting mRNA and protein synthesis, especially in pox viruses. It has been used in the past to treat smallpox.[1]

Methisazone has been described as being used in prophylaxis since at least 1965.[2][3]


  1. Methisazone, Merriam-Webster's Medical Dictionary
  2. do Valle, LA; de Melo, PR; de Gomes, LF; Proença, LM (13 Nov 1965). "Methisazone in prevention of variola minor among contacts". Lancet. 2 (7420): 976–8. PMID 4159212.
  3. Weiss MM, Weiss PD, Mathisen G, Guze P (December 2004). "Rethinking smallpox". Clin. Infect. Dis. 39 (11): 1668–73. doi:10.1086/425745. PMID 15578369.