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mitochondrially encoded 16S RNA
Alt. symbolsMTRNR2
Other data
LocusChr. MT [1]
File:Map of the human mitochondrial genome.svg
Location of the MT-RNR2 gene on the H strand of the human mitochondrial genome. MT-RNR2, or RRNL, is one of the two mitochondrial ribosomal RNA genes (blue boxes).

Mitochondrially encoded 16S RNA (often abbreviated as 16S) is a mitochondrial ribosomal RNA (rRNA)[1][2] that in humans is encoded by the MT-RNR2 gene. The MT-RNR2 gene also encodes the Humanin polypeptide that has been the target of Alzheimer's disease research.[3][4]

The 16S rRNA is the mitochondrial homologue of the prokaryotic 23S and eukaryotic nuclear 28S ribosomal RNAs.[5]

See also


  1. Noda R, Kim CG, Takenaka O, et al. (2001). "Mitochondrial 16S rRNA sequence diversity of hominoids". J. Hered. 92 (6): 490–6. doi:10.1093/jhered/92.6.490. PMID 11948216.
  2. Nagy A, Wilhelm M, Kovacs G (February 2003). "Mutations of mtDNA in renal cell tumours arising in end-stage renal disease". J. Pathol. 199 (2): 237–42. doi:10.1002/path.1273. PMID 12533837.
  3. Maximov V, Martynenko A, Hunsmann G, Tarantul V (December 2002). "Mitochondrial 16S rRNA gene encodes a functional peptide, a potential drug for Alzheimer's disease and target for cancer therapy". Med. Hypotheses. 59 (6): 670–3. doi:10.1016/S0306-9877(02)00223-2. PMID 12445508.
  4. Tajima H, Niikura T, Hashimoto Y, et al. (May 2002). "Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults". Neurosci. Lett. 324 (3): 227–31. doi:10.1016/S0304-3940(02)00199-4. PMID 12009529. Archived from the original on 2013-01-22.
  5. Eperon, I. C.; Anderson, S.; Nierlich, D. P. (1980-07-31). "Distinctive sequence of human mitochondrial ribosomal RNA genes". Nature. 286 (5772): 460–467. doi:10.1038/286460a0.