DRESS syndrome secondary prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Serge Korjian M.D.

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Secondary preventive measures to avoid DRESS syndrome include avoidance of drug re-exposure, screening for cross-reacting agents using in vitro lymphocyte toxicity assays, and possibly desensitization techniques.

Secondary Prevention

Secondary preventive measures to avoid DRESS syndrome include the following:[1]

  • Avoid re-exposure to drugs that have previously caused DRESS syndrome
  • Screen for cross-reacting agents using in vitro lymphocyte toxicity assays
  • Desensitization has not been reported to be effective in some case reports, but the true effectiveness of the desensitization has not been studied.[2]


  1. Tas S, Simonart T (2003). "Management of drug rash with eosinophilia and systemic symptoms (DRESS syndrome): an update". Dermatology. 206 (4): 353–6. doi:69956 Check |doi= value (help). PMID 12771485.
  2. Moreno-Ancillo A, López-Serrano MC (1998). "Hypersensitivity reactions to drugs in HIV-infected patients. Allergic evaluation and desensitization". Clin Exp Allergy. 28 Suppl 4: 57–60. PMID 9761034.

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