DRESS syndrome historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Serge Korjian M.D.

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The early descriptions of DRESS syndrome were made in the 1940s and 1950s. The term DRESS syndrome was first coined by Helene Bocquet, a French dermatologist, in 1996.

Historical Perspective

  • DRESS syndrome was first described by Saltzstein in 1959. However, it is thought that DRESS syndrome may have described earlier since the 1940s following the introduction of hydantoin and reports of hydantoin-induced lymphadenopathy.[1]
  • Initially, DRESS syndrome was occasionally termed either drug-induced pseudolymphoma given its clinical presentation that often mimics lymphoma or anticonvulsant hypersensitivity syndrome given its association with use of anticonvulsant agents.[2][3]
  • The term DRESS syndrome was first coined by Helene Bocquet, a French dermatologist, in 1996.[4]


  1. Coope, R; Burrows, R (1940). "Treatment of epilepsy with sodium diphenyl hydantoine". Lancet. 1: 490–2. |access-date= requires |url= (help)
  2. SALTZSTEIN SL, ACKERMAN LV (1959). "Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically pathologically malignant lymphomas". Cancer. 12 (1): 164–82. PMID 13618867.
  3. Vittorio CC, Muglia JJ (1995). "Anticonvulsant hypersensitivity syndrome". Arch Intern Med. 155 (21): 2285–90. PMID 7487252.
  4. Bocquet H, Bagot M, Roujeau JC (1996). "Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS)". Semin Cutan Med Surg. 15 (4): 250–7. PMID 9069593.

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