DRESS syndrome risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D., Serge Korjian M.D.


There are no established risk factors in the development of DRESS syndrome. Possible risk factors in the development of DRESS syndrome include positive family history and rapid dose escalation of the triggering agent.

Risk Factors

  • There are no established risk factors for the development of DRESS syndrome.
  • Possible risk factors in the development of DRESS syndrome include:
  • Positive family history for DRESS syndrome[1][2]
  • Rapid dose escalation of the triggering drug[3]

To view the list of drugs that are associated with DRESS syndrome, click here.


  1. Tas S, Simonart T (1999). "Drug rash with eosinophilia and systemic symptoms (DRESS syndrome)". Acta Clin Belg. 54 (4): 197–200. PMID 10544509.
  2. Sullivan JR, Shear NH (2001). "The drug hypersensitivity syndrome: what is the pathogenesis?". Arch Dermatol. 137 (3): 357–64. PMID 11255340.
  3. Fitton A, Goa KL (1995). "Lamotrigine. An update of its pharmacology and therapeutic use in epilepsy". Drugs. 50 (4): 691–713. PMID 8536554.

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