DRESS syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D., Serge Korjian M.D.


Laboratory findings of patients with DRESS syndrome usually differ depending on the organ involvement. Common Lab findings include anemia, eosinophilia, atypical lymphocytosis, monocytosis, and thrombocytopenia

Laboratory Findings

The following laboratory tests are usually performed to identify DRESS syndrome and associated complications:

Laboratory findings of patients with DRESS syndrome usually differ depending on the organ involvement. The reported incidence of organ involvement has been highly variable in described cases. The following table illustrates the incidence of organ involvement in DRESS syndrome:[1][2][3]

Incidence of organ involvement in DRESS syndrome
Organ Percent of patients with involvement
Liver 60% - 90%
Kidney 40% - 50%
Pulmonary 30% - 40%
Cardiac/muscular 15% -20%
Pancreas 5% - 10%
Lung 5% - 10%

The following table illustrates the incidence of common lab abnormalities associated with DRESS syndrome:[1][2][3]

Incidence of hematologic abnormalities in DRESS syndrome
Abnormality Percent of patients with abnormality
Atypical lymphocytes 60% - 70%
Eosinophilia 50% - 70%
Anemia 50% - 60%
Monocytosis 40% - 50%
Lymphocytopenia 40% - 50%
Thrombocytopenia 25% - 50%
Lymphocytosis 25% - 50%


  1. 1.0 1.1 Avancini J, Maragno L, Santi CG, Criado PR (2015). "Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome: clinical features of 27 patients". Clin Exp Dermatol. doi:10.1111/ced.12682. PMID 26271788.
  2. 2.0 2.1 Chen YC, Chiu HC, Chu CY (2010). "Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases". Arch Dermatol. 146 (12): 1373–9. doi:10.1001/archdermatol.2010.198. PMID 20713773.
  3. 3.0 3.1 Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L; et al. (2011). "The DRESS syndrome: a literature review". Am J Med. 124 (7): 588–97. doi:10.1016/j.amjmed.2011.01.017. PMID 21592453.

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