Acute lymphoblastic leukemia history and symptoms

Jump to navigation Jump to search

Acute lymphoblastic leukemia Microchapters


Patient Information


Historical Perspective



Differentiating Acute lymphoblastic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings


Chest X Ray

Bone X Ray

Echocardiograph and Ultrasound



Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Acute lymphoblastic leukemia history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Acute lymphoblastic leukemia history and symptoms

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Acute lymphoblastic leukemia history and symptoms

CDC on Acute lymphoblastic leukemia history and symptoms

Acute lymphoblastic leukemia history and symptoms in the news

Blogs on Acute lymphoblastic leukemia history and symptoms

Directions to Hospitals Treating Acute lymphoblastic leukemia

Risk calculators and risk factors for Acute lymphoblastic leukemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Carlos A Lopez, M.D. [3]


Symptoms of acute lymphoblastic leukemia include generalized weakness and fatigue, frequent or unexplained fever and infections, weight loss and/or loss of appetite, excessive bruising, bleeding from wounds, nosebleeds, petechiae, bone pain, joint pains and dyspnea.


Patients with acute lymphoblastic leukemia may have a positive history of:[1][2][3][4][5]


Common symptoms

Common symptoms of acute lymphoblastic leukemia include the following:[6][7][8][9][4]

Less common symptoms


  1. Bakhshi S, Padmanjali KS, Arya LS (June 2008). "Infections in childhood acute lymphoblastic leukemia: an analysis of 222 febrile neutropenic episodes". Pediatr Hematol Oncol. 25 (5): 385–92. doi:10.1080/08880010802106564. PMID 18569840.
  2. Sutor AH, Mall V, Thomas KB (1999). "Bleeding and thrombosis in children with acute lymphoblastic leukaemia, treated according to the ALL-BFM-90 protocol". Klin Padiatr. 211 (4): 201–4. doi:10.1055/s-2008-1043788. PMID 10472550.
  3. Steele M, Narendran A (October 2012). "Mechanisms of defective erythropoiesis and anemia in pediatric acute lymphoblastic leukemia (ALL)". Ann. Hematol. 91 (10): 1513–8. doi:10.1007/s00277-012-1475-5. PMID 22543829.
  4. 4.0 4.1 Terwilliger T, Abdul-Hay M (June 2017). "Acute lymphoblastic leukemia: a comprehensive review and 2017 update". Blood Cancer J. 7 (6): e577. doi:10.1038/bcj.2017.53. PMC 5520400. PMID 28665419.
  5. Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton W (March 2016). "Symptoms of adult chronic and acute leukaemia before diagnosis: large primary care case-control studies using electronic records". Br J Gen Pract. 66 (644): e182–8. doi:10.3399/bjgp16X683989. PMC 4758497. PMID 26917658.
  6. Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ (October 2016). "Clinical presentation of childhood leukaemia: a systematic review and meta-analysis". Arch. Dis. Child. 101 (10): 894–901. doi:10.1136/archdischild-2016-311251. PMID 27647842.
  7. Vesterby A, Myhre Jensen O (September 1985). "Aseptic bone/bone marrow necrosis in leukaemia". Scand J Haematol. 35 (3): 354–7. PMID 4059858.
  8. Sinigaglia R, Gigante C, Bisinella G, Varotto S, Zanesco L, Turra S (2008). "Musculoskeletal manifestations in pediatric acute leukemia". J Pediatr Orthop. 28 (1): 20–8. doi:10.1097/BPO.0b13e31815ff350. PMID 18157042.
  9. Pui CH (January 2009). "Acute lymphoblastic leukemia: introduction". Semin. Hematol. 46 (1): 1–2. doi:10.1053/j.seminhematol.2008.09.011. PMC 2638983. PMID 19100362.
  10. Aboud, H.; Treleaven, J.; Carter, R.; O'Brien, M.; Powels, R. (1991). "An adult with common acute lymphoblastic leukaemia (C-ALL) presenting with skin infiltration". British Journal of Dermatology. 124 (1): 84–85. doi:10.1111/j.1365-2133.1991.tb03287.x. ISSN 0007-0963.
  11. Brix N, Rosthøj S, Herlin T, Hasle H (2015). "Arthritis as presenting manifestation of acute lymphoblastic leukaemia in children". Arch Dis Child. 100 (9): 821–5. doi:10.1136/archdischild-2014-307751. PMID 26216831.

Template:WH Template:WS