Acute lymphoblastic leukemia epidemiology and demographics

Jump to: navigation, search

Acute lymphoblastic leukemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Acute lymphoblastic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

Bone X Ray

Echocardiograph and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Acute lymphoblastic leukemia epidemiology and demographics On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Acute lymphoblastic leukemia epidemiology and demographics

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Acute lymphoblastic leukemia epidemiology and demographics

CDC on Acute lymphoblastic leukemia epidemiology and demographics

Acute lymphoblastic leukemia epidemiology and demographics in the news

Blogs on Acute lymphoblastic leukemia epidemiology and demographics

Directions to Hospitals Treating Acute lymphoblastic leukemia

Risk calculators and risk factors for Acute lymphoblastic leukemia epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Rim Halaby, M.D. [3] Carlos A Lopez, M.D. [4]

Overview

In 2015, the incidence of acute lymphoblastic leukemia was approximately 2 per 100,000 individuals with a case-fatality rate of approximately 20% in the United States. Males are more commonly affected with acute lymphoblastic leukemia compared to females.

Epidemiology and Demographics

Incidence and Mortality 2015

  • In 2015, the incidence of acute lymphoblastic leukemia was estimated to be 2 per 100,000 individuals in the United States.[1]
  • The case fatality rate of acute lymphoblastic leukemia is approximately 20% in the United States.

Prevalence

  • In the United States, the age-adjusted prevalence of acute lymphoblastic leukemia is 17.4 per 100,000 in 2011.[2]

Incidence

  • The number of annual acute lymphoblastic leukemia cases in the United States is roughly 4000, 3000 of which inflict children.[3]

Age

  • Acute lymphoblastic leukemia has been reported at 80 percent of all childhood leukemia cases, making it the most prevalent type of childhood cancer.[4]
  • It has a peak incident rate of 2-5 years old, going down in incidence with increasing age before going up again at around 50 years old.[5]
  • While the overall age-adjusted incidence of acute lymphoblastic leukemia in the United States between 2007 and 2011 is 1.7 per 100,000, the age-adjusted incidence of acute lymphoblastic leukemia by age category is:[2]
    • Under 65 years: 1.7 per 100,000
    • 65 and over: 1.6 per 100,000

Gender

  • Acute lymphoblastic leukemia is slightly more common in males than females.[6]
  • In the United States, the age-adjusted prevalence of acute lymphoblastic leukemia by gender in 2011 is:[2]
    • In males: 19.3 per 100,000
    • In females: 15.4 per 100,000
  • In the United States, the age-adjusted incidence of acute lymphoblastic leukemia by gender on 2011 is:[2]
    • In males: 1.9 per 100,000 persons
    • In females: 1.63 per 100,000 persons
  • Shown below is an image depicting the observed incidence of lymphocytic leukemia by gender in the United States between 1975 and 2011. These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.[2]

Observed incidence of lymphocytic leukemia by gender in the United States between 1975 and 2011

Race

  • Shown below is a table depicting the age-adjusted prevalence of acute lymphoblastic leukemia by race in 2011 in the United States.[2]
All Races White Black Asian/Pacific Islander Hispanic
Age-adjusted 17.4 per 100,000 20 per 100,000 7.6 per 100,000 13.2 per 100,000 20.8 per 100,000

References

  1. "National Cancer Institute".
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
  3. Guru Murthy, Guru Subramanian; Pondaiah, Satish Kumar; Abedin, Sameem; Atallah, Ehab (2018). "Incidence and survival of T-cell acute lymphoblastic leukemia in the United States". Leukemia & Lymphoma: 1–8. doi:10.1080/10428194.2018.1522442. ISSN 1042-8194.
  4. Bhojwani D, Howard SC, Pui CH (2009). "High-risk childhood acute lymphoblastic leukemia". Clin Lymphoma Myeloma. 9 Suppl 3: S222–30. doi:10.3816/CLM.2009.s.016. PMC 2814411. PMID 19778845.
  5. Barrington-Trimis JL, Cockburn M, Metayer C, Gauderman WJ, Wiemels J, McKean-Cowdin R (2017). "Trends in childhood leukemia incidence over two decades from 1992 to 2013". Int J Cancer. 140 (5): 1000–1008. doi:10.1002/ijc.30487. PMC 5550103. PMID 27778348.
  6. Esparza SD, Sakamoto KM (2005). "Topics in pediatric leukemia--acute lymphoblastic leukemia". MedGenMed. 7 (1): 23. PMC 1681386. PMID 16369328.

Linked-in.jpg