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{{ | '''Interleukin-1 receptor accessory protein''' is a [[protein]] that in humans is encoded by the ''IL1RAP'' [[gene]].<ref name="pmid9479509">{{cite journal |vauthors=Dale M, Hammond DW, Cox A, Nicklin MJ | title = The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping | journal = Genomics | volume = 47 | issue = 2 | pages = 325–6 |date=April 1998 | pmid = 9479509 | pmc = | doi = 10.1006/geno.1997.5113 }}</ref><ref name="pmid9065432">{{cite journal |vauthors=Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU | title = The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases) | journal = J Biol Chem | volume = 272 | issue = 12 | pages = 7727–31 |date=April 1997 | pmid = 9065432 | pmc = | doi =10.1074/jbc.272.12.7727 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IL1RAP interleukin 1 receptor accessory protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3556| accessdate = }}</ref> | ||
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| summary_text = Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.<ref name="entrez" | | summary_text = Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.<ref name="entrez" /> | ||
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==Interactions== | |||
IL1RAP has been shown to [[Protein-protein interaction|interact]] with [[TOLLIP]]<ref name=pmid10854325>{{cite journal |last=Burns |first=K |authorlink= |author2=Clatworthy J |author3=Martin L |author4=Martinon F |author5=Plumpton C |author6=Maschera B |author7=Lewis A |author8=Ray K |author9=Tschopp J |author10=Volpe F |date=June 2000 |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor |journal=Nat. Cell Biol. |volume=2 |issue=6 |pages=346–51 |publisher= |location = ENGLAND| issn = 1465-7392| pmid = 10854325 |doi = 10.1038/35014038 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[Interleukin 1 receptor, type I]].<ref name=pmid9371760>{{cite journal |last=Huang |first=J |authorlink= |author2=Gao X |author3=Li S |author4=Cao Z |date=November 1997 |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=94 |issue=24 |pages=12829–32 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9371760 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.94.24.12829 |pmc=24223 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Greenfeder SA, Nunes P, Kwee L, etal |title=Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex |journal=J. Biol. Chem. |volume=270 |issue= 23 |pages= 13757–65 |year= 1995 |pmid= 7775431 |doi=10.1074/jbc.270.23.13757 }} | ||
*{{cite journal | *{{cite journal |vauthors=Parnet P, Garka KE, Bonnert TP, etal |title=IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 3967–70 |year= 1996 |pmid= 8626725 |doi=10.1074/jbc.271.8.3967 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Huang J, Gao X, Li S, Cao Z |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 24 |pages= 12829–32 |year= 1998 |pmid= 9371760 |doi=10.1073/pnas.94.24.12829 | pmc=24223 }} | ||
*{{cite journal | *{{cite journal |vauthors=Cullinan EB, Kwee L, Nunes P, etal |title=IL-1 receptor accessory protein is an essential component of the IL-1 receptor |journal=J. Immunol. |volume=161 |issue= 10 |pages= 5614–20 |year= 1998 |pmid= 9820540 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Lang D, Knop J, Wesche H, etal |title=The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness |journal=J. Immunol. |volume=161 |issue= 12 |pages= 6871–7 |year= 1999 |pmid= 9862719 |doi= }} | ||
*{{cite journal | | *{{cite journal |vauthors=Morton NM, de Groot RP, Cawthorne MA, Emilsson V |title=Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells |journal=FEBS Lett. |volume=442 |issue= 1 |pages= 57–60 |year= 1999 |pmid= 9923604 |doi=10.1016/S0014-5793(98)01623-8 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Sizemore N, Leung S, Stark GR |title=Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4798–805 |year= 1999 |pmid= 10373529 |doi= | pmc=84278 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Jensen LE, Muzio M, Mantovani A, Whitehead AS |title=IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein |journal=J. Immunol. |volume=164 |issue= 10 |pages= 5277–86 |year= 2000 |pmid= 10799889 |doi= 10.4049/jimmunol.164.10.5277}} | ||
*{{cite journal | *{{cite journal |vauthors=Burns K, Clatworthy J, Martin L, etal |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor |journal=Nat. Cell Biol. |volume=2 |issue= 6 |pages= 346–51 |year= 2000 |pmid= 10854325 |doi= 10.1038/35014038 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Bigonnesse F, Marois M, Maheux R, Akoum A |title=Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle |journal=Mol. Hum. Reprod. |volume=7 |issue= 4 |pages= 333–9 |year= 2001 |pmid= 11279295 |doi=10.1093/molehr/7.4.333 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jefferies C, Bowie A, Brady G, etal |title=Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1 |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4544–52 |year= 2001 |pmid= 11416133 |doi= 10.1128/MCB.21.14.4544-4552.2001 | pmc=87113 }} | ||
*{{cite journal | *{{cite journal |vauthors=Radons J, Gabler S, Wesche H, etal |title=Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16456–63 |year= 2002 |pmid= 11880380 |doi= 10.1074/jbc.M201000200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ruhul Amin AR, Machida K, Oshima K, etal |title=A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling |journal=Oncogene |volume=21 |issue= 57 |pages= 8871–8 |year= 2003 |pmid= 12483539 |doi= 10.1038/sj.onc.1206018 }} | ||
*{{cite journal | | *{{cite journal |author1=Smith DE |author2=Hanna R |author3=Della Friend |title=The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action |journal=Immunity |volume=18 |issue= 1 |pages= 87–96 |year= 2003 |pmid= 12530978 |doi=10.1016/S1074-7613(02)00514-9 |display-authors=etal}} | ||
*{{cite journal | *{{cite journal |vauthors=Boch JA, Yoshida Y, Koyama Y, etal |title=Characterization of a cascade of protein interactions initiated at the IL-1 receptor |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 2 |pages= 525–31 |year= 2003 |pmid= 12659850 |doi=10.1016/S0006-291X(03)00385-1 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Bin LH, Xu LG, Shu HB |title=TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24526–32 |year= 2003 |pmid= 12721283 |doi= 10.1074/jbc.M303451200 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Jensen LE, Whitehead AS |title=Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis |journal=Cell. Signal. |volume=15 |issue= 8 |pages= 793–802 |year= 2004 |pmid= 12781872 |doi=10.1016/S0898-6568(03)00039-1 }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Revision as of 23:47, 31 August 2017
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| Location (UCSC) | n/a | n/a | |||||
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Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.[1][2][3]
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.[3]
Interactions
IL1RAP has been shown to interact with TOLLIP[4] and Interleukin 1 receptor, type I.[5]
References
- ↑ Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509.
- ↑ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
- ↑ 3.0 3.1 "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein".
- ↑ Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. ENGLAND. 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325.
- ↑ Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.
Further reading
- Greenfeder SA, Nunes P, Kwee L, et al. (1995). "Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex". J. Biol. Chem. 270 (23): 13757–65. doi:10.1074/jbc.270.23.13757. PMID 7775431.
- Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP". J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725.
- Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760.
- Cullinan EB, Kwee L, Nunes P, et al. (1998). "IL-1 receptor accessory protein is an essential component of the IL-1 receptor". J. Immunol. 161 (10): 5614–20. PMID 9820540.
- Lang D, Knop J, Wesche H, et al. (1999). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". J. Immunol. 161 (12): 6871–7. PMID 9862719.
- Morton NM, de Groot RP, Cawthorne MA, Emilsson V (1999). "Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells". FEBS Lett. 442 (1): 57–60. doi:10.1016/S0014-5793(98)01623-8. PMID 9923604.
- Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit". Mol. Cell. Biol. 19 (7): 4798–805. PMC 84278. PMID 10373529.
- Jensen LE, Muzio M, Mantovani A, Whitehead AS (2000). "IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein". J. Immunol. 164 (10): 5277–86. doi:10.4049/jimmunol.164.10.5277. PMID 10799889.
- Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
- Bigonnesse F, Marois M, Maheux R, Akoum A (2001). "Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle". Mol. Hum. Reprod. 7 (4): 333–9. doi:10.1093/molehr/7.4.333. PMID 11279295.
- Jefferies C, Bowie A, Brady G, et al. (2001). "Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1". Mol. Cell. Biol. 21 (14): 4544–52. doi:10.1128/MCB.21.14.4544-4552.2001. PMC 87113. PMID 11416133.
- Radons J, Gabler S, Wesche H, et al. (2002). "Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling". J. Biol. Chem. 277 (19): 16456–63. doi:10.1074/jbc.M201000200. PMID 11880380.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ruhul Amin AR, Machida K, Oshima K, et al. (2003). "A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling". Oncogene. 21 (57): 8871–8. doi:10.1038/sj.onc.1206018. PMID 12483539.
- Smith DE; Hanna R; Della Friend; et al. (2003). "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action". Immunity. 18 (1): 87–96. doi:10.1016/S1074-7613(02)00514-9. PMID 12530978.
- Boch JA, Yoshida Y, Koyama Y, et al. (2003). "Characterization of a cascade of protein interactions initiated at the IL-1 receptor". Biochem. Biophys. Res. Commun. 303 (2): 525–31. doi:10.1016/S0006-291X(03)00385-1. PMID 12659850.
- Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
- Jensen LE, Whitehead AS (2004). "Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis". Cell. Signal. 15 (8): 793–802. doi:10.1016/S0898-6568(03)00039-1. PMID 12781872.
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